Xi Chen Professor
Department of Occupational and Environmental Health
Research direction
Health effects of environmental endocrine disruptors (EDCs) and persistent organic pollutants (POPs).
Education
Ph.D. Tianjin Medical University, Tianjin, China, 2012
MD Tianjin Medical University, Tianjin, China, 2009
Bachelor Tianjin Medical University, Tianjin, China, 2006
Professional Experience
01/2021– Professor, Tianjin Medical University, China
01/2015–12/2020 Associate Professor, Tianjin Medical University, China
06/2015–07/2016 Visiting scholar, UC Berkeley, US
09/2012–12/2014 Instructor, Tianjin Medical University, China
Project
1. Study on the effect of perfluorinated compounds exposure on breast cancer and its estrogen receptor mediated mechanism. Funded by National Natural Science Foundation of China. 01. 2020-12. 2023. Principal Investigator
2. Study on the Mechanism of Altering the Steroidogenesis Function of Human Placenta via Protein Complex in the Placental Mitochondrial after the Exposure to Dioxins. Funded by National Natural Science Foundation of China. 01. 2013-12. 2017. Principal Investigator
3. Role of the Cross-regulation between Neurons and Astrocytes for the Neurotoxicity of Dioxin. Funded by TianJin Municipal Science and Technology Commission. 04. 2014-03. 2017. Principal Investigator
4. Study on the mitochondrial interference mechanism of tetrabromobisphenol A affecting human placental hormones. Funded by Postdoctoral Foundation of China. 05. 2017-05. 2019. Principal Investigator
5. Early identification of respiratory and cardiovascular health effects of air pollution. Funded by National Key R&D Program of China (2017YFC0211605).2017.07-2020.12. Main Investigator
Publication
1. Li X, Song F, Liu X, Shan A, Huang Y, Yang Z, Li H, Yang Q, Yu Y, Zheng H, Cao XC, Chen D, Chen KX, Chen X*, Tang NJ*. Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case-control study in Chinese population. Environ Health. 2022 Sep 9;21(1):83.
2. Zhang A, Wang R, Liu Q, Yang Z, Lin X, Pang J, Li X, Wang D, He J, Li J, Zhang M, Yu Y, Cao XC, Chen X, Tang NJ. Breast adipose metabolites mediates the association of tetrabromobisphenol a with breast cancer: A case-control study in Chinese population. Environ Pollut. 2023 Jan 1;316(Pt 1):120701.
3. Li X, Sun X, Zhang A, Pang J, Li Y, Yan M, Xu Z, Yu Y, Yang Z, Chen X, Wang X, Cao XC, Tang NJ. Breast microbiome associations with breast tumor characteristics and neoadjuvant chemotherapy: A case-control study. Front Oncol. 2022 Sep 12;12:926920.
4. Anqi Shan#, Xi Chen#, Xueli Yang, Baoqun Yao, Fengchao Liang, Ze Yang, Fangchao Liu, Song Chen, Xiaochang Yan, Jianfeng Huang, Shaoye Bo, Nai-Jun Tang, Dongfeng Gu, Hua Yan*. Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China. Environ Int. 2021 Apr 17;154:106568.
5. Wang L, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res. 2020 Sep;188:109752.
6. Anqi Shan, Ling Leng, Jing Li, Xiu-mei Luo, Ya-jiao Fan, Qiaoyun Yang, Qun-hui Xie, Yang-sheng Chen, Chun-sheng Ni, Li-ming Guo, Hua Tang, Xi Chen*, Nai-jun Tang*. TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells. Journal of Hazardous Materials. Volume 398, 5 November 2020, 122869. doi.org/10.1016/j.jhazmat.2020.122869
7. Shan A, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res. 2020 Jul;186:109551.
8. Yan M, Li C, Zhang L, Chen X, Yang X, Shan A, Li X, Wu H, Ma Z, Zhang Y, Guo P, Dong G, Liu Y, Chen J, Wang T, Zhao B, Tang NJ*. Association between long-term exposure to Sulfur dioxide pollution and hypertension incidence in northern China: a 12-year cohort study. Environ Sci Pollut Res Int. 2020 Jun; 27(17): 21826-21835.
9. Shan A#, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res, 2020 Jul; 186: 109551.
10. Wang L#, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res, 2020 May 30; 188: 109752.
11. Shan A, Li M, Li X, Li Y, Yan M, Xian P, Chang Y, Chen X*, Tang NJ. BDE-47 decreases progesterone levels in BeWo cells by interfering with mitochondrial functions and genes related to cholesterol transport. Chem Res Toxicol. 2019 Feb 4. doi: 10.1021/acs.chemrestox.8b00312. [Epub ahead of print]
12. Zhang HJ, Liu YN, Xian P, Ma J, Sun YW, Chen JS, Chen X*, Tang NJ*. Maternal exposure to TCDD during gestation advanced sensory-motor development, but induced impairments of spatial learning and memory in adult male rat offspring. Chemosphere. 2018 Aug 23;212:678-686.
13. Chen X, Wang X, Huang JJ, Zhang LW, Song FJ, Mao HJ, Chen KX, Chen J, Liu YM, Jiang GH, Dong GH, Bai ZP, Tang NJ*. Nonmalignant respiratory mortality and long-term exposure to PM10 and SO2: A 12-year cohort study in northern China. Environ Pollut. 2017 Aug 30;231(Pt 1):761-767.
14. Chen X, Zhang LW, Huang JJ, Song FJ, Zhang LP, Qian ZM, Trevathan E, Mao HJ, Han B, Vaughn M, Chen KX, Liu YM, Chen J, Zhao BX, Jiang GH, Gu Q, Bai ZP, Dong GH, Tang NJ*. Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China. Sci Total Environ. 2016 Nov 15;571:855-61.
15. Chen X, Chen JS, Zhang L, Li JG, Yao L, Self SG, Sun X, Tang NJ*. Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of a chemical plant in Tianjin: A primary study. Chemosphere. 2015, 118: 1-4.
16. Chen X, Leng L, Yu H, Yang XL, Dong GH, Yue S, Chen JS, Tang NJ*. Psychological distress and dyslipidemia in chinese police officers: a 4-year follow-up study in Tianjin, China. J Occup Environ Med. 2015, 57(4):400-5.
17. Chen X, Zhou QH, Leng L, Chen X, Sun ZR, Tang NJ*. Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1. Environ Toxicol Pharmacol. 2013, 36(2):332-8.
18. Chen X, Liu YN, Zhou QH, Leng L, Chang Y, Tang NJ*. Effects of low concentrations of di-(2-ethylhexyl) and mono-(2-ethylhexyl) phthalate on steroidogenesis pathways and apoptosis in the murine leydig tumor cell line MLTC-1. Biomed Environ Sci. 2013, 26(12):986-9.
19. Chen X, Ma SW, Ma XM, Xu YJ, Tang NJ*. Changes in fibrinopeptide A peptides in the sera of rats chronically exposed to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ Toxicol Pharmacol. 2012, 33(2):191-6.
20. Chen X, Ma XM, Ma SW, Coenraads PJ, Zhang CM, Liu J, Zhao LJ, Sun M, Tang NJ*. Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J Toxicol Environ Health A. 2009, 72(11-12):717-26.
21. Ma J, Chen X (Co-first Authors), Liu Y, Xie Q, Sun Y, Chen J, Leng L, Yan H, Zhao B, Tang N*. Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs.Toxicol Appl Pharmacol. 2015, 289(2):193-202.
22. Zhang LW, Chen X (Co-first Authors), Xue XD, Sun M, Han B, Li CP, Ma J, Yu H, Sun ZR, Zhao LJ, Zhao BX, Liu YM, Chen J, Wang PP, Bai ZP*, Tang NJ*. Long-term exposure to high particulate matter pollution and cardiovascular mortality: a 12-year cohort study in four cities in northern China. Environ Int. 2014, 62:41-7.
23. Dong GH, Zhang P, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and respiratory disease mortality in Shenyang, China: a 12-year population-based retrospective cohort study. Respiration. 2012, 84(5):360-8.
24. Bao J, Zeng XW, Qin XD, Lee YL, Chen X, Jin YH, Tang NJ, Dong GH*. Phthalate Metabolites in Urine Samples from School Children in Taipei, Taiwan. Arch Environ Contam Toxicol. 2015, 69(2):202-7.
25. Zhang P, Dong G, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and mortality due to cardiovascular disease and cerebrovascular disease in Shenyang, China. PLoS One. 2011;6(6):e20827.
26. Liu J, Zhang CM, Coenraads PJ, Ji ZY, Chen X, Dong L, Ma XM, Han W, Tang NJ*. Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins. Toxicol Lett. 2011, 25;201(3):230-4.
27. Guo L, Peng C, Xu H, Wilson A, Li PH, Wang H, Liu H, Shen L, Chen X, Qi X, Tang NJ, Barrow TM, Byun HM. Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Womens Health. 2018 Nov 9;18(1):182.
28. Li C, Liu JC, Xiao X, Chen X, Yue S, Yu H, Tian FS, Tang NJ. Psychological distress and type 2 diabetes mellitus: a 4-year policemen cohort study in China. BMJ Open. 2017 Jan 27;7(1):e014235.
29. Yu H, Liu JC, Fan YJ, Li C, Zhang LX, Chen X, Yue S, Lu WL, Yang XL, Tang NJ. Association between occupational stressors and type 2 diabetes among Chinese police officers: a 4-year follow-up study in Tianjin, China. Int Arch Occup Environ Health. 2016 Feb;89(2):277-88.
30. Leng L, Chen X, Li CP, Luo XY, Tang NJ. 2,3,7,8-Tetrachlorodibezo-p-dioxin exposure and prostate cancer: a meta-analysis of cohort studies. Public Health. 2014 Mar;128(3):207-13.
31. Regazzoni LG, Grigoryan H, Ji Z, Chen X, Daniels SI, Huang D, Sanchez S, Tang N, Sillé FC, Iavarone AT, Williams ER, Zhang L, Rappaport SM. Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood. Toxicol Lett. 2017 Feb 15;268:26-35.
Membership of Academic Society
Branch of Industrial Toxicology, Chinese Society of Toxicology (CSOT)
Branch of Environmental Health, Chinese Preventive Medicine Association (CPMA)
Branch of Toxicology, Chinese Preventive Medicine Association (CPMA)
Branch of Biomarkers, Chinese Society of Environmental Mutagens