Liqiong Guo Lecture
Occupational & Environmental Health department
Emailguoliqiong@
Resume
Liqiong Guo, PhD serves as the Occupational & Environmental Health department lecture in Tianjin Medical University. As an epigenetic and environmental health researcher, Dr. Guo’s research explores epigenetic and molecular mechanisms as potential functional pathways linking exposures to environmental pollutants to human disease. Her laboratory research activities are specifically focused on epigenetics, mitochondriomics, and computational epigenomics. Dr. Guo is currently the PI of National Natural Science of China project.Recent and ongoing projects investigate health effects from environmental exposures, including particulate air pollution, metals, Bisphenol A, and common risk factors, such as environmental noise, second-hand smoking, and maternal diet and metabolic alterations. Dr. Guo’s research team has been conducting studies on the Tianjin population (ELEFANT Project-- The project Environmental and LifEstyle FActors iN metabolic health throughout life-course Trajectories, around 140,000 participants) which involved many brilliant scientists from China, Italy, UK, U.S., Spain and other countries.
Research direction
Molecular Epidemiology, Environmental Epidemiology, Environmental Health, Epigenetics
Education
2010-2014 Nankai University&Harvard University, Environmental Health (Ph.D)
2011-2013 Harvard School of Public Health Department of Environmental Health , Lab of Human Environmental Epigenomics (JointPh.D)
2007-2010 Huazhong Agricultural University, Veterinary (M.S.)
2003-2007 Huazhong Agricultural University, Biological Science (B.S
Professional Experience
2015- Instructor, Occupational & Environmental Health department, School of Public Health, Tianjin Medical University
Project as PI
1.National Natural Science Foundation of China
G rant Number: 81971416
Role: Principal Investigator
Amount: ￥550,000
Length in Months: 48 (01/01/2020-12/31/2023)
Title: Platelet Mitochondrial DNA Methylation and risk of Unexplained Recurrent Spontaneous Abortion—a nested case-control Study
2.National Natural Science Foundation of China
Number: 81602827
Role: Principal Investigator
Amount:￥180,000
Length in Months: 36 (01/01/2017-12/31/2019)
Title:Platelet Mitochondrial DNA Methylation: New Biomarker of Particulate Matter Effects
3.Tianjin Natural Science Foundation
Number:
Role: Principal Investigator
Amount:￥60,000
Length in Months: 36 (04/01/2018-03/31/2021)
Title: Mitochondrial DNA Methylation: New Biomarker of CVD
4.The Science Foundation of Tianjin Medical University
Number: 2GW033
Role: Principal Investigator
Amount:￥10,000
Length in Months: 24 (01/01/2016-12/31/2017)
Title: Platelet Mitochondrial Epigenetics: New Markers of PAHs Exposure
Publication (Recent 5 years)
(1) Timothy M. Barrow, Cheng Peng, Ander Wilson, Hao Wang, Hongbin Liu, Lilin Shen, Nai-jun Tang, Chanachai Sae-Lee, Peng-hui Li,Liqiong Guo*, Hyang-Min Byun, Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT. Breast Cancer Research and Treatment, 2019, 173: 217-224
(2) Peng-hui Li*, Hong-yan Jia, Yan Wang, Tao Li, Lei Wang, Qian-qian Li, Min-min Yang, Jun-jie Yue, Xian-liang Yi,Li-qiong Guo*, Characterization of PM2.5-bound phthalic acid esters (PAEs) at regional background site in northern China: Long-range transport and risk assessment. Science of the Total Environment, 2019, 659:140-149
(3)Liqiong Guo#*, Cheng Peng#, Hui Xu#, Ander Wilson, Peng-hui Li, Hao Wang, Hongbin Liu, Lilin Shen, Xi Chen, Xiuying Qi, Nai-jun Tang, Timothy M. Barrow, Hyang-Min Byun, Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Women's Health, 2018, 18: 182
(4) Hui Xu#, Peng-hui Li#, Timothy M. Barrow, Elena Colicino, Changping Li, Ruixue Song, Hongbin Liu, Nai-jun Tang, Songyan Liu,Liqiong Guo*, HyangMin Byun, Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT. Plos One, 2018, 13(11): e0207929
(5)Liqiong Guo#*, Peng-hui Li, Hua Li, Elena Colicino, Silvia Colicina, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M. Barrow, Akin Cayir, Andrea A. Baccarelli, Hyang-Min Byun. Effect of environmental noise exposure on DNA methylation in the brain and metabolic health. Environmental Research. 2017; 153:73-82.
(6) Timothy M. Barrow, Hyang-Min Byun, Xinyan Li, Chris Smart, Yong-Xiang Wang, Yacong Zhang, Andrea A. Baccarelli,Liqiong Guo*, The effect of morphine upon DNA methylation in ten regions of the rat brain. Epigenetics, 2017, 12: 1038-1047
(7)Liqiong Guo#*, Hyang-Min Byun, Jia Zhong, Valeria Motta, Jitendra Barupal, Yinan Zheng, Chang Dou, Feiruo Zhang, John P. McCracken, Anaité Diaz, Sanchez-Guerra Marco, Silvia Colicino, Joel Schwartz, Sheng Wang, Lifang Hou, Andrea A. Baccarelli. Effects of Short-term Exposure to Inhalable Particulate Matter on Tandem Repeats DNA Methylation. Environ Mol Mutagen, 2014. 55(4): 322-335
(8)Liqiong Guo#, Hongxiang Chen, Yongsheng Li, Qixing Zhou*, Yang Sui*. An Aquaporin 3-Notch Axis in Keratinocyte Differentiation and Inflammation. Plos One, 2013. 8(11): e80179
(9) Akin Cayir*, Timothy M. Barrow,Liqiong Guo, Hyang-Min Byun.Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes. Environ Res. 2019, 175:228-234.
(10) Peng-hui Li, Jie Yu, Cheng-liang Bi, Jun-jie Yue, Li Wang, Jinpeng Liu*, Zhimei Xiao,Liqiong Guo, Bi-jie Huang*. Health risk assessment for highway toll station workers exposed to PM2.5-bound heavy metals.Atmospheric Pollution Research. 2019, 10(4):1024-1030.
(11) Octavio Jiménez-Garza#*,Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Briscia SocorroBarrón-Vivanco, Andrea A. Baccarellie. Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture. Toxicol Appl Pharmacol. 2018, 339: 65-72.
(12) Octavio Jiménez-Garza#*,Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci,Jia Zhong,Andrea A. Baccarellie. Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: Searching for biomarkers of oncogenesis. Food Chem Toxicol. 2017 Nov;109(Pt 1):669-676.
(13) Hong-yan Jia, Lei Wang, Peng-hui Li*, Yan Wang*,Li-qiong Guo, Tao Li, Lei Sun, You-ping Shou, Tian-yu Mao, Xian-liang Yi, Characterization, long-Range transport and source identification of carbonaceous aerosols during spring and autumn periods at a high mountain site in south China. Atmosphere, 2016,7: atmos7100122
(14) Peng-Hui Li*, Yan Wang*, Tao Li, Lei Sun, Xianliang Yi,Li-qiong Guo, Rui-hong Su, Characterization of carbonaceous aerosols at Mount Lu in South China: implication for secondary organic carbon formation and long-range transport. Environment Science and Pollution Research, 2015, 22: 14189-14199
(15) Akin Cayir, Timothy M. Barrow, Hao Wang, Hongbin Liu, Changping Li, Ning Ding, Yan Li, Choong-Min Kang,Liqiong Guo, Peng-hui Li*, Hyang-Min Byun, Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT. Plos One, 2018, 13(12): e0209041
(16) Yu-jie Zhao, You-ping Shou, Tian-yu Mao,Li-qiong Guo, Peng-hui Li*, Xianliang Yi, Qian-qian Li, Li-zhu Shen, Huan-rong Zuo, Jing Wang, Lei Wang, PAHs exposure assessment for highway toll station workers through personal particulate sampling and urinary biomonitoring in Tianjin, China. Polycyclic Aromatic Compounds, 2016, DOI: 10.1080/10406638.2016.1220959
(17) Lifang Hou#*, Xiao Zhang#, Yinan Zheng, Sheng Wang, Chang Dou,Liqiong Guo, Hyang-Min Byun, Valeria Motta, John McCracken, Anaite Diaz, Choong-Min Kang, Petros Koutrakis, Pier Alberto Bertazzi, Jingyun Li, Joel Schwartz, Andrea A. Baccarelli. Altered Methylation in Tandem Repeat Element and Elemental Component Levels in Inhalable Air Particles. Environ Mol Mutagen, 2013. 55(3): 256-265.
(18) Jun-Jie Yue, Roberta Palmiero, Yang-Yang Han, Yan Wang, Qian-Qian Li, Tuo-Yu Zhang, Meiqing Sun, Hong Wang, Guangping Yu, Xian-Liang Yi, Peng-Hui Li*, Ya-Qin Ji*,Li-Qiong Guo, Characterization of PM1-bound Metallic Elements in the Ambient Air at a High Mountain Site in Northern China. Aerosol and Air Quality Research, 2018, 18:2967-2981
(19) Jing Liu, Yan Wang, Peng-Hui Li*, You-Ping Shou*, Tao Li, Min-Min Yang, Lei Wang, Jun-Jie Yue, Xian-Liang Yi,Li-Qiong Guo, Polycyclic Aromatic Hydrocarbons (PAHs) at High Mountain Site in North China: Concentration, Source and Health Risk Assessment. Aerosol and Air Quality Research, 2017, 17: 2867-2877
Membership of Academic Society
Beijing society of Environmental Mutagen
Tianjin Medical Association of Rare Diseases Branch Committee
Honors
Tianjin Innovative Talents Promotion Program Young Science and Technology Talents
The third level of “131” talent in Tianjin, 2015