Xumei Zhang Professor
Department of Nutrition and Food Science
Emailzhangxumei@
Resume
Research direction
Major research interests lie in the field of the relationships between some nutrients and the neurodegenerative diseases (or aging) and the underlying molecular mechanisms.
Education
Postdoctoral Fellow Tianjin Medical University, Tianjin, China, 2013.6-2017.1
Ph.D. Academy of Military Medical Sciences, Tianjin, China, 2003.9-2006.7
M.Sc. Sichuan Agriculture University, Sichuan, China, 2000.9-2003.7
B.Sc. Liaocheng Teacher’s University, Shandong, China, 1994.9-1998.7
Professional Experience
l2017.12- present Professor, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. doctoral supervisor, vice director
l2009.10-2017.12 Associate Professor, Department of Nutrition and Food Hygiene,Tianjin Medical University, Tianjin, China.
l2010.7-2011.7 Visiting scholar, School of Public Health, John Hopkins University, Baltimore, USA.
l2006.7-2009.10 Lecturer, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China.
Project
1.Effect and mechanism of folic acid on cognitive function following brain ischemia through lncRNA and NMDA receptor -mediated synaptic plasticity. National Natural Science Foundation of China (No. 81874262), 2019/01-2022/12, Director.
2.Studies on the effect of homocysteine on neural stem cell proliferation and differentiation by DNA methylation and its mechanism. National Natural Science Foundation of China (No. 81373003), 2014/01-2017/12, Director.
3.Molecular mechanisms of how the genes related to folate/homocysteine metabolism regulate neural stem cell proliferation and differentiation in the rats, National Natural Science Foundation of China (No.30901192), 2009.12-2012.12, Director.
4.The effects of folic acid deficiency on neural cell injury after cerebral ischemia reperfusion in rats and its autouphagy-related mechanisms(2014M550148), 2014.4-2015.5, Director.
5.The effects of homocysteine on neural stem cell proliferation and differentiation in the rats”. Science Funds of Tianjin Education Commission (No.20070208), 2007.11-2010.11, Director.
6.12th and 13th Five-Year Tianjin young and middle-aged backbone innovative talent support program, Director.
7.“Epigenetic effects of folic acid on Alzheimer's disease by DNA methylation.” Key Project of National Natural Science Foundation of China (No. 81130053), 2012.1-2016.12, Major Investigator.
Publication
1.Chen S(#), Dong Z, Cheng M, Zhao Y, Wang M, Sai N, Wang X, Liu H, Huang G, Zhang X(*). Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. J Neuroinflammation. 2017 Sep 18; 14(1): 187.
2.Chen S(#), Dong Z, Zhao Y, Sai N, Wang X, Liu H, Huang G, Zhang X(*). Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain.Sci Rep. 2017 Jul 31; 7(1): 6932.
3.Zhao Yaqian(#), Huang Guowei, Chen Shuang, Gou Yun, Dong Zhiping, Zhang Xumei(*). Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia, J Nutr Biochem, 2016, 38: 41-49.
4.Zhao Yaqian(#), Huang Guowei, Chen Shuang, Gou Yun, Dong Zhiping, Zhang Xumei (*). Homocysteine aggravates cortical neural cell injury through neuronal autophagy overactivation following rat cerebral ischemia-reperfusion，International Journal of Molecular Sciences, 2016, 17(8): pi1196.
5.Zhang Xumei(#), Zhao Yaqian, Yan Hai, Liu Huan, Huang Guowei (*). Inhibitory effect of homocysteine on rat neural stem cell growth in vitro is associated with reduced protein levels and enzymatic activities ofaconitase and respiratory complex III. J Bioenerg Biomembr, 2017 Apr; 49(2):131-138.
6.Lin Ningning(#), Qin Shanchun, Luo Suhui, Cui Shanshan, Huang Guowei(*), Zhang Xumei (*). Homocysteine induces cytotoxicity and proliferation inhibition in neural stem cells via DNA methylation in vitro, Febs J, 2014, 281(8): 2088-2096.
Recruits students specialized
Graduated Master student: 4
Master student: 4
Membership of Academic Society
1.Member of Chinese Nutrition Society
2.Vice Secretary-General of Tianjin Nutrition Society
Honors
1.Distinguished Youth Award by Chinese Nutrition Society
2.Advanced Society Workers by Tianjin Association for science and technology
3.“Outstanding Talents in the New Century, Pioneers of Women’s Achievements, Outstanding Trade Union Activists and Excellent class mentorof Tianjin Medical University.