He Chen, Ph.D.
He Chen, PhD
Associate Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Email: chenhe@
Education
Ph.D. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China, 2017
B.S. Hebei University, Baoding, China, 2012
Professional Experience
2022- present Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2018-2021 Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2017-2018 Senior Researcher, STA Pharmaceutical Co., Ltd. Shanghai, China
Research Interest
1. Development of novel PROTAC degraders for the treatment of cancer/cardiovascular diseases.
2. Discovery of selective small molecule inhibitors or probes for chemical biology research.
(1) Chen, H.#; Liu, J.#; Kaniskan, H. Ü.; Wei, W. *; Jin, J.*Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras.J. Med. Chem.2021,64, 12273. (#Authors contributed equally) (IF 8.0).
(2) Liu, J.#; Chen, H.#; Kaniskan, H. Ü.; Xie, L.; Chen,X.; Jin, J.*; Wei, W. * TF-PROTACs enable targeted degradation of transcription factors. J. Am. Chem. Soc. 2021, 143, 8902. (#Authors contributed equally) (Highlighted by X-mol) (IF 16.4).
(3) Liu, J.#; Chen, H.#; Liu, Y.; Shen,Y.; Meng, F.; Kaniskan, H. Ü.; Jin, J.*; Wei, W. * Cancer selective target degradation by folate-caged PROTACs. J. Am. Chem. Soc.2021, 143, 7380. (#Authors contributed equally) (Highlighted by X-mol) (IF 16.4).
(4) Liu, J.#; Chen, H.#; Ma, L.; He, Z.; Wang, D.; Liu, Y.; Lin, Q.; Zhang, T.; Gray, N.; Kaniskan, H. Ü.; Jin, J.*; Wei, W.* Light-Induced Control of Protein Destruction by Opto-PROTAC. Sci. Adv.2020, 6, eaay5154. (#Authors contributed equally) (Highly cited paper (top 1%) from Web of Science) (IF 15.0).
(5) Chen, H.; Liu, Z.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.* Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature. Angew. Chem. Int. Ed. 2017, 56, 15411. (IF 16.8).
(6) Chen, H.; Zhu, L.; Li, C.* Silver-Catalyzed Radical Carbofluorination of Unactivated Alkenes with Acetic Acid in Aqueous Solution. Org. Chem. Front.2017, 4, 565. (Organic Chemistry Frontiers HOT articles for 2017) (IF 5.5).
(7) Liu, J.; Yu, X.; Chen, H.; Kaniskan, H. Ü.; Xie, L.; Chen, X.; Jin, J.; Wei, W. TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors. J. Am. Chem. Soc. 2022, 144, 12934. (IF 16.3).
(8) Zhang, S.; Chen, H.; Zhang, C.; Yang, Y.; Popov, P.; Liu, J.; Krumm, B. E.; Cao, C.; Kim, K.; Xiong, Y.; Katritch, V.; Shoichet, B. K.; Jin, J.; Fay, J. F.; Roth, B. L. Inactive and Active State Structures Template Selective Tools for the Human 5-HT5A Receptor. Nat. Struct. Mol. Biol.2022, 29, 677. (IF 18.4).
(9) Cao, C.#; Kang, H. J.#; Singh, I.; Chen, H.; Zhang, C.; Ye, W.; Hayes, B. W.; Liu, J.; Gumpper, R. H.; Bender, B. J.; Slocum, S.; Krumm, B. E.; Lansu, K.; McCorvy, J. D.; Kroeze, W. K.; English, J. G.; DiBerto, J. F.; Olsen. R. H. J.; Huang, X-P.; Zhang, S.; Liu, Y.; Kim, K.; Karpiak, J.; Jan, L. Y.; Abraham, S. N.; Jin, J.; Shoichet, B. K. *; Fay, J. F.*; Roth, B. L.* Structure, Function and Pharmacology of Human Itch GPCRs. Nature2021, 600, 170. (IF 69.5).
(10)Wei, J.; Meng, F.; Park, K.; Yim, H.; Velez, J.; Kumar, P.; Wang, L.; Xie, L.; Chen, H.; Shen, Y.; Teichman, E.; Wang, G.; Chen, X.; Kaniskan, H.*; Jin, J.* Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J. Am. Chem. Soc. 2021, 143, 15073. (IF 16.4)
(11) Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Chau, I.; Eram, M. S.; Dela Seña, C.; Park, K. S.; Meng, F.; Chen, H.; Zeng, H.; Dong, A.; Wu, H.; Trush, V. V.; Mcleod, D.; Zepeda-Velázquez, C. A.; Campbell, R. M.; Mader, M. M.; Watson, B. M.; Schapira, M.; Arrowsmith, C. H.; Al-Awar, R.; Barsyte-Lovejoy, D.; Kaniskan, H. Ü.; Brown, P. J.; Vedadi, M.; Jin, J. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J. Med. Chem. 2021, 64, 3697. (IF 8.0).
(12) Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Park, K.-S.; Chau, I.; Dong, A.; Zeng, H.; Chen, H.; Meng, F.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P. J.; Liu, J.*; Vedadi, M.*; Jin, J.* Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J. Med. Chem.2020, 63, 5477. (IF 8.0).
(13) Liu, Z.; Chen, H.; Lv, Y.; Tan, X.; Shen, H.; Yu, H.-Z.; Li, C.* Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions. J. Am. Chem. Soc. 2018, 140, 6169. (IF 16.4).
(14) Tan, X.; Song, T.; Wang, Z.; Chen, H.; Cui, L.; Li, C.* Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids. Org. Lett. 2017, 19, 1634. (IF 6.1).
(15)Zhou, S.; Song, T.; Chen, H.; Liu, Z.; Shen, H.; Li, C.* Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes. Org. Lett. 2017, 19, 698. (IF 6.1).
(16) Cui, L.; Chen, H.; Liu, C.; Li, C.* Silver-Catalyzed Decarboxylative Allylation of Aliphatic Carboxylic Acids in Aqueous Solution. Org. Lett. 2016, 18, 2188. (IF 6.1).
(17) Zhu, L.; Chen, H.; Wang, Z.; Li, C.* Formal Fluorine Atom Transfer Radical Addition: Silver-Catalyzed Carbofluorination of Unactivated Alkenes with Ketones in Aqueous Solution. Org. Chem. Front. 2014, 1, 1299. (Organic Chemistry Frontiers HOT articles for 2014) (IF 5.5).
Patents
(1) Wei, W.; Jin, J.; Kaniskan, H. Ü.; Chen, H.; Photo-induced control of protein destruction. PCT Int. Appl. (2021), WO 2021016521, 20210128.
(2) Jin, J.; Burakoff, S.; Kaniskan, H. Ü.; Sawasdikosol, S.; Chen, H.; Brody, J.; Bhardwaj, N. Heterobifunctional compounds as degraders of HPK1. PCT Int. Appl. (2020), WO 2020227325, 20201112.
(3) Jin, J.; Xiong, Y.; Liu, J.; Zhang, C.; Han, X.; Chen, H.; Wang, P. Compositions and methods for treating ALK-mediated cancer. PCT Int. Appl. (2019), WO 2019113071, 20190613.
Grants
Ongoing:
1. The National Natural Science Foundation of China (Grant No. 82204223), PI.
Completed:
1. The National Natural Science Foundation of China (Grant No. 21602239), participant.
