Lulu Wang, Professor
发布人：药学院-英文  发布时间：2022-05-10   浏览次数:423

 

Lulu Wang, Ph.D.

 


Lulu Wang, PhD

Professor

Department of Pharmacy

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-18513506057

Email: wanglulu@tmu.edu.cn

 

Education

PhD                             Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, 2006

Postdoctoral Fellow     Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, 2012

Postdoctoral Fellow     MD Anderson Cancer Center, Houston, Texas,USA, 2014

 

Professional Experience

2022-           Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China

2019-2021   Research Scientist, Department of Clinical Cancer Prevention,  MD Anderson Cancer Center, Houston, Texas,USA

 

Research Interest

 

  1. Discover the function of chromatin remodeling complex in DNA damage response network and its application in cancer therapy. We aim to explore the SWI/SNF complex in promoting tumorigenesis by both in vitro and in vivo studies, which may lead to identification of new strategy for cancer therapy .

     

  2. Identify epigenetic alterations in the genome maintenance mechanisms that confers anti-tumor immunity.

    The tumor development is often accompanied by genome-wide epigenetic abnormality, we aim to investigate the underlying mechanism leading to genomic instability and immunity of tumor.

 

  1. Discover novel agents targeting the genome maintenance mechanisms by genetic and chemical approaches, we aim to employ systematic large-scale chemical screening and in vivo CRISPR/Cas9 screen as our drug-discovery platforms to  identify chemical compounds that target the DNA damage response and repair network.

     

 

Professional Service

 

 

Publications(since 2013)

  1. L Wang, L Yang, W Zhao, Z Ju, W Zhang, J Shen, Y Peng, C An, Y T Luu, S Song, TA Yap, JA Ajani, GB Mills, X Shen and G Peng (2020) Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. The Journal of Clinical Investigation 130 (11) (Impact Factor: 14.434)

  2. J Liang#, L Wang*, C Wang*, J Shen, B Su, A Marisetty, D Fang, C Kassab, KJ Jeong, W Zhao, Y Lu, AK Jain, Z Zhou, H Liang, SC Sun, C Lu, ZX Xu, Q Yu, S Shao, X Chen, M Gao, FX Claret, Z Ding, J Chen, P Chen, MC Barton, G Peng, GB Mills, AB Heimberger (2020) Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis, exerting antitumor efficacy. Cancer Immunology Research (Impact Factor: 9.876)

  3. X Deng*, T Lu*, L Wang*, L Gu, J Sun, X Kong, C Liu, X Cao. (2016) Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Proceedings of the National Academy of Sciences U.S.A. 113(19), 5447-5452. (Impact Factor: 10.285)

  4. L Wang, X Song, L Gu, X Li, S Cao, C Chu, X Cui, X Chen, and X Cao. (2013) NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis. Plant Cell 25, 715-727. (Impact factor: 9.618)

  5. J Shen, Z Ju, W Zhao, L Wang, Y Peng, Z Ge, Z Nagel, J Zou, C Wang, P Kapoor, X Ma, D Ma, J Liang, S Song, J Liu, L Samso, J Ajani, G Li, H Liang, X Shen, G. B. Mills, and G Peng (2018) ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nature Medicine 24, 556–562. (Impact Factor: 49.248)

  6. J Shen, W Zhao, Z Ju, L Wang, Y Peng, M Labrie, TA Yap, G B Mills, G Peng. (2019) PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness. Cancer research 79 (2), 311-319 (Impact Factor: 9.883）

  7. X Dong, S Song, Y Li, Y Fan, L Wang, R Wang, Y Xu, L Huo, MP Pizzi, L Ma, A Scott, Y Wang, J Jin, W Zhao, X Yao, R Johnson, Li Wang, G Peng, ZWang, J A. Ajani. (2020) Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-Rationale for targeting Arid1A deficiency. Gut (Impact Factor: 17.751)

  8. J Zou, W Qin, L Yang, L Wang, Y Wang, J Shen, S Yu, S Song, J A Ajani, S Lin, G B Mills, XYuan, J Chen and Guang Peng. (2020) Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. American Journal of Cancer Research 10 (11), 3947 (Impact Factor: 5.177)

  9. RK Yang, GA Toruner, W Wang, H Fang, GC Issa, L Wang, AE Quesada, B Thakral, KP Patel,G Peng, S Liu, CC Yin, G Borthakur, Z Tang, SA Wang, RN Miranda, JD Khoury, LJ Medeiros, G Tang (2021) CBFB Break-Apart FISH Testing: An Analysis of 1629 AML Cases with a Focus on Atypical Findings and Their Implications in Clinical Diagnosis and Management. Cancers (Basel) 13(21)  ( Impact Factor: 6.639)

  10. Y Yin, W Liu, Q Shen, P Zhang, L Wang, R Tao, H Li, X Ma, X Zeng, JH Cheong, S Song, JA Ajani, GB Mills, K Tao, G Peng (2019) The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer. Molecular cancer therapeutics 18 (8), 1439-1450. (Impact Factor: 5.373)

  11. L Zhang, Y Peng, IP Uray, J Shen, L Wang, X Peng, PH Brown, W Tu, G Peng. (2017) Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy. DNA repair 60, 89-101. (Impact Factor:3.388)

  12. S Kumar, X Peng, J Daley, L Yang, J Shen, N Nguyen, G Bae, H Niu, Y Peng, H Hsieh, LWang, C Rao, C C Stephan, P Sung, G Ira, G Peng. (2017) Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells. Oncogenesis6, e319. (Impact Factor: 5.479)

  13. L Zhang, J Shen, Y Yin, Y Peng, L Wang, HJ Hsieh, Q Shen, PH Brown, and G Peng (2017). Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening. SLAS DISCOVERY: Advancing Life Sciences R&D 22, 813-826. (Impact factor:2.192)

  14. Y Zhang, L Gu, Y Hou, C Liu, L Wang, X Deng, R Hang, D Chen, C Shao, Y Zhang, and X Cao. (2015) Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation. Cell Research 25, 864-876. (Impact Factor: 20.396)

  15. L Wei, L Gu, X Song, X Cui, Z Lu, M Zhou, L Wang, F Hu, J Zhai, B C. Meyers and X Cao. (2014) Dicer-like 3 produces MITE-associated heterochromatic-siRNAs that control agricultural traits in rice. Proceedings of the National Academy of Sciences U.S.A. 111, 3877-3882. (Impact Factor: 10.285)

     

Grants

Ongoing:

 

 

Completed:

  1. Mechanism of Arginine methyltransferase AtPRMT3 involved in ribosome Assembly and translation, 2013-2014, China Postdoctoral Science Foundation (Grant No. 2013M530762), PI