Dongxing Chen, Ph.D.
Dongxing Chen, PhD
Professor
Department of Medicinal Chemistry, School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Email: chendongxing@tmu.edu.cn
Education
Ph.D. Medicinal Chemistry, China Pharmaceutical University, 2016
B.S. Pharmacy, China Pharmaceutical University, 2011
Professional Experience
2021-present Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2017-2021 Postdoctoral Research Fellow, College of Pharmacy, Purdue University, USA
2016-2017 Postdoctoral Research Fellow, School of Pharmacy, Virginia Commonwealth University, USA
Research Interest
1. Studies of bioactive molecules targeting methyltransferases.
2. Medicinal chemistry and chemical biology for the substrate receptors of E3 Ub ligases.
Professional Service
Reviewer for:
Journal of Medicinal Chemistry, ACS Chemical Biology, ACS Medicinal Chemistry Letters, Scientific Reports, Bioorganic & Medicinal Chemistry, etc.
Membership of Academic Society
American Association for the Advancement of Science (AAAS)
1. Guangping Dong, Iredia D. Iyamu, Jonah Z. Vilseck, Dongxing Chen and Rong Huang*, Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1, Molecules 2022, 27(4), 1381.
2. Dongxing Chen, Ying Meng, Dan Yu, Nicholas Noinaj, Xiaodong Cheng, and Rong Huang*, Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors, ACS Chemical Biology, 2021, 16(7), 1234–1242.
3. Dongxing Chen, Guangping Dong,Youchao Deng,Nicholas Noinaj, Rong Huang*, Structure-based Discovery of Cell-potent Peptidomimetic Inhibitors for Protein N-terminal Methyltransferase 1, ACS Medicinal Chemistry Letters, 2021, 12(3), 485-493.
4. Dongxing Chen, Cheng Dong, Guangping Dong, Karthik Srinivasan, Jinrong Min, Nicholas Noinaj, Rong Huang*. Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs. Journal of Medicinal Chemistry, 2020, 63(15), 8419–8431.
5. Brianna D. Mackie, Dongxing Chen, Guangping Dong, Cheng Dong, Haley Parker, Christine E. Schaner Tooley, Nicholas Noinaj, Jinrong Min, Rong Huang*. Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. Journal of Medicinal Chemistry,2020, 63(17), 9512–9522.
6. Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang*. Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5. Acta Pharmaceutica Sinica B，2021，11(9), 2709-2718.
7. Dongxing Chen§, Linjie Li§, Krystal Diaz, Iredia D. Iyamu, Ravi Yadav, Nicholas Noinaj, Rong Huang*. Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase. Journal of Medicinal Chemistry, 2019, 62(23), 10783-10797.
8. Dongxing Chen§, Guangping Dong§, Nicholas Noinaj, Rong Huang*. Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1. Journal of Medicinal Chemistry, 2019, 62(7), 3773-3779.
9. Dongxing Chen, Jinyu Shi, Qiufang Chen, Rui Zhang, Guoqing Gong, Yungen Xu *, Qihua Zhu*. Design, Synthesis and Biological Evaluation of Thrombin Inhibitors with 1,2,3,4-Tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine Nucleus. Chemical Journal of Chinese Universities-Chinese, 2017, 38(6), 1059-1067.
10. Dongxing Chen§, Jinyu Shi§, Jing Liu, Xueying Zhang, Xiaoying Deng, Yanyan Yang, Shuang Cui, Qihua Zhu*, Guoqing Gong, Yungen Xu*. Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25(2), 458-470.
11. Dongxing Chen§, Shaochi Wang§, Xiaojuan Diao, Qihua Zhu, Huiliang Shen, Xueqing Han, Yiwei Wang, Guoqing Gong, Yungen Xu*. Design, Synthesis and Antithrombotic Evaluation of Novel Dabigatran EtexilateAnalogues, a New Series of Non-peptides Thrombin Inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(23), 7405–7416.
12. Meng Liu, Jie Huang, Dongxing Chen, Cheng Jiang*. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2015, 25(3), 431–434.
13. Dongxing Chen, Jie Huang, Meng Liu, Yungen Xu*, Cheng Jiang*. Design, Synthesis, and Evaluation of Non-ATP-Competitive Small-Molecule Polo-Like Kinase 1 (Plk1) Inhibitors. Archiv Der Pharmazie, 2015, 348, 2–9.
Grants
1. Protein N-terminal Methylation Mechanisms and Inhibition. Project supported by the National Institutes of Health (USA), Ongoing, Major participant;
2. Design and Synthesis of Novel Thrombin Inhibitors based-on Scaffold Hopping and Pharmacophore. Project supported by the National Natural Science Foundation of China, Exec Date 2013-2016, Completed, Major participant.
