Zhen Zheng, Ph.D.
Zhen Zheng, PhD
Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Email: zhengzhen90@tmu.edu.cn
Education
Ph.D. Analytical Chemistry, University of Science and Technology of China, 2017
B.S. Chemistry, Nanjing University (NJU), 2012
Professional Experience
2021-present Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2018-2021 Postdoctoral Researcher, School of Pharmacy, University of Wiscosin-Madison, USA
2017-2018 Postdoctoral Researcher, College of Pharmacy, The Ohio State University, USA
Honors
Science and Technology Second Class Award of Anhui Province (2020)
Chinese Academy of Sciences Presidential Award (2017)
Outstanding Graduate Awards of Anhui Province (2017)
Excellent Doctoral Thesis of USTC (2017)
Representative (one of twenty) to attend the 67th Nobel Prize Laureates Meeting in Germany (2017)
Outstanding member of the Communist Party (2017)
National Scholarship for Graduate (2016)
First Prize in the 2nd Graduate Symposium on Chemistry (2016)
Outstanding Undergraduate Award of NJU (2012)
Excellent Student Leader Award (2012)
Membership of Academic Society
Member of the Chinese Chemical Society
Member of the American Chemical Society
Member of International Society of RNA Nanotechnology and Nanomedicine
Publication
First author & co-first author papers:
1. Zhen Zheng, Jillian L. Kyzer, Adam Worob, and Cody J. Wenthur*. Family of Structurally Related Bioconjugates Yields Antibodies with Differential Selectivity against Ketamine and 6-Hydroxynorketamine.ACS Chem. Neurosci. 2021, DOI (10.1021/acschemneuro.1c00498).
2. Zhen Zheng,# Zhefeng Li,# Congcong Xu, Bin Guo, and Peixuan Guo*. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J. Control. Release 2019, 311-312, 43-49. (#, co-first author)
3. Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang*, and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumor therapy. Nat. Commun. 2019, 10, 1192. (#, co-first author)
4. Jindao Wu,#* Zhen Zheng,# Jing Xu, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang*, Fuqiang Wang* and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30, 1805018. (#, co-first author)
5. Zhen Zheng,# Peiyao Chen,# Gongyu Li,# Yunxia Zhu,# Zhonghua Shi, Yufeng Luo, Chun Zhao, Ziyi Fu, Xianwei Cui, Chenbo Ji, Fuqiang Wang,* Guangming Huang,* and Gaolin Liang*.Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid. Chem. Sci. 2017, 8, 214-222. (#, co-first author)
6. Zhen Zheng, Gongyu Li, Chengfan Wu, Miaomiao Zhang, Yue Zhao, and Gaolin Liang*. Intracellular synthesis of D-aminoluciferin for bioluminescence generation. Chem. Commun. 2017, 53, 3567-3570.
7. Chengfan Wu,#Zhen Zheng,# Yuenan Guo, Chongli Tian, Qiang Xue,* and Gaolin Liang*. Fluorine substitution enhances the self-assembling ability of hydrogelators. Nanoscale 2017, 9, 11429-11433. (#, co-first author)
8. Zhen Zheng, Peiyao Chen, Maolin Xie, Chengfan Wu, Yufeng Luo, Wentao Wang, Jun Jiang and Gaolin Liang*. Cell Environment-Differentiated Self-Assembly of Nanofibers. J. Am. Chem. Soc. 2016, 138, 11128-11131.
9. Zhen Zheng, Hongbin Sun, Chen Hu, Gongyu Li, Xiaomei Liu, Peiyao Chen, Yusi Cui, Jing Liu, Junfeng Wang, and Gaolin Liang*. Using “On/Off” 19F NMR/MRI Signals to Sense Tyrosine Kinase/Phosphatase Activity in Vitro and in Cell Lysates. Anal. Chem. 2016, 88, 3363-3368.
10. Zhen Zheng,#Anming Tang,# Yong Guan, Liang Chen, Fuqiang Wang, Peiyao Chen, Weijuan Wang, Yufeng Luo, Yangchao Tian and Gaolin Liang*. Nanocomputed Tomography Imaging of Bacterial Alkaline Phosphatase Activity with an Iodinated Hydrogelator. Anal. Chem. 2016, 88, 11982-11985. (#, co-first author)
11. Zhen Zheng, Lin Wang, Wei Tang, Peiyao Chen, Hui Zhu, Yue Yuan, Gongyu Li, Huafeng Zhang, and Gaolin Liang*. Hydrazide D-luciferin for in vitro selective detection and intratumoral imaging of Cu2+. Biosens. Bioelectron. 2016, 83, 200-204.
12. Zhen Zheng,# Jihao Wang,# Peiyao Chen, Maolin Xie, Lei Zhang, Yubin Hou, Xin Zhang, Jun Jiang, Junfeng Wang,* Qingyou Lu,* and Gaolin Liang*. Using L-STM to directly visualize enzymatic self-assembly/disassembly of nanofibers. Nanoscale 2016, 8, 15142-15146. (#, co-first author)
13. Zhen Zheng, Gaolin Liang*. Magnetic resonance imaging-guided stratified selection of patients for nano-therapy. Ann. Transl. Med. 2016, 4, S54.
Non-first author papers:
14. Gongyu Li, Junfeng Huang, Zhen Zheng, Qinjingwen Cao, Yuwei Tian, Guangming Huang, Lingjun Li and Brandon Ruotolo*. Bicarbonate Buffers Can Promote Crosslinking and Alternative Gas-phase Dissociation Pathways for Multiprotein Complexes. Int. J. Mass Spectrom. 2021, 469, 116687.
15. Miaomiao Zhang, Yong Guan, Zheng Dang, Pinggen Zhang, Zhen Zheng, Liang Chen, Wen Kuang, Chenchen Wang, and Gaolin Liang*. Directly Observe Intracellular Nanoparticle Formation with Nanocomputed Tomography. Sci. Adv.2020, 6, eaba3190.
16. Congcong Xu, Kaiming Zhang, Hongran Yin, Zhefeng Li, Alexey Krasnoslobodtsev, Zhen Zheng, Zhouxiang Ji, Sijin Guo, Shanshan Li, Wah Chiu, Peixuan Guo*. 3D RNA Nanocage for Encapsulation and Shielding of Hydrophobic Biomolecules to Improve the in vivo Biodistribution. Nano Res. 2020, 13, 3241-3247.
17. Gongyu Li, Fengfei Ma, Qinjingwen Cao, Zhen Zheng, Kellen DeLaney, Rui Liu and Lingjun Li*. Nanosecond, photochemically promoted click chemistry for enhanced neuropeptide visualization and rapid protein labeling. Nat. Commun. 2019, 10, 4697.
18. Peiyao Chen, Wen Kuang, Zhen Zheng, Shuye Yang, Yaling Liu, Lanhong Su, Kui Zhao, and Gaolin Liang*. Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging. Theranostics 2019, 9, 7359-7369.
19. Peixuan Guo*, Dana Driver, Zhengyi Zhao, Zhen Zheng, Chun Chan, and Xiaolin Cheng. Controlling the Revolving and Rotating Motion Direction of Asymmetric Hexameric Nanomotor by Arginine Finger and Channel Chirality. ACS Nano 2019, 13, 6207-6223.
20. Peiyao Chen, Zhen Zheng, Yunxia Zhu, Yu Dong, Fuqiang Wang*, Gaolin Liang*. Bioluminescent Turn-On Probe for Sensing Hypochlorite in Vitro and in Tumors. Anal. Chem. 2017, 89, 5693-5696.
21. Gongyu Li, Siming Yuan, Shihui Zheng, Yuting Chen, Zhen Zheng, Yangzhong Liu, Guangming Huang*. The Effect of Salts in Promoting Specific and Competitive Interactions between Zinc Finger Proteins and Metals. J. Am. Soc. Mass Spectrom. 2017, 28, 2658-2664.
22. Yue Yuan,# Fuqiang Wang,# Wei Tang, Zhanling Ding, Lin Wang, Lili Liang, Zhen Zheng, Huafeng Zhang, and Gaolin Liang*. Intracellular Self-Assembly of Cyclic D-Luciferin Nanoparticles for Persistent Bioluminescence Imaging of Fatty Acid Amide Hydrolase. ACS Nano 2016, 10, 7147-7153. (#, co-first author)
Grant
1. Project supported by the National Institutes of Health (USA), Exec Date 2020-2025, Ongoing, Major participant;
2. Project supported by the National Natural Science Foundation of China, Exec Date 2016-2018, Completed, Major participant.
Research Interest
Self-assembly peptide; Synthetic small-molecule vaccine; Controlled release
