Jingyuan Xu, Professor
发布人：药学院-英文  发布时间：2019-12-13   浏览次数:251

 


Jing-Yuan Xu, Ph.D.

 

Jing-Yuan Xu, PhD

Professor, Director of Department of Chemical Biology

School of Pharmacy

Tianjin Medical University

No.22 Qixiangtai Road, Heping District

Tianjin, 300070 China

Phone: +86-022-83336929 (O)

Email: xujingyuan@tmu.edu.cn

ORCID: orcid.org/0000-0002-1660-412X

 

Education

B.S.    Tianjin Normal University, Tianjin, China, 1987-1991

M.S.   Tianjin Normal University, Tianjin, China, 1991-1994

Ph.D.  Nankai University, Tianjin, China, 2000-2003

Postdoctoral ResearcherUniversite Paris XI-Sud, Paris, France, 2003-2004

Postdoctoral ResearcherJustus-Liebig-University, Giessen, Germany, 2004-2005

 

Professional Experience

1994-1996   Assistant, School of Pharmacy, Tianjin Medical University, China

1996-2001   Lecturer, School of Pharmacy, Tianjin Medical University, China

2001-2006   Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

2010-2011   Visiting professor, Department of Chemistry, Massachusettes Institute of Technology, MA, USA

2014-2021   Professor, Vice Dean, School of Pharmacy, Tianjin Medical University, Tianjin, China

2006-           Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

 

Research Interest

  1. Innovative research and development of Pt-based anti-tumor drugs (design, synthesis, activity screening and action mechanism of novel Pt-based anti-tumor compounds)

  2. Study on fluorescent probes for biological small-molecules

     

    Honors

  3. First-level key posts employed by Tianjin Medical University, 2020

  4. Tianjin famous teacher, China, 2019

  5. Tianjin Natural Science Award, Third-level prize (Ranked first), Tianjin, China, 2019

  6. Honorary title of Female Achievement Model of Tianjin Medical University, 2018

  7. Achievement Award of Science and Technology of Tianjin Medical University, 2018

  8. Leader of Tianjin teaching team, China, 2017

  9. Discipline leading talents in universities of Tianjin, China, 2017

  10. Distinguished professor of Tianjin, China, 2012

  11. Young and middle aged key innovative talents of Tianjin, China, 2012

  12. Tianjin Natural Science Award, Third-level prize (Ranked first), Tianjin, China, 2007

  13. First-level key posts employed by Tianjin Medical University, 2011

  14. Second-level key posts employed by Tianjin Medical University, 2009

  15. Excellent teachers,Tianjin Medical University, Tianjin, China, 2007

  16. Talents in the New Century,Tianjin Medical University, Tianjin, China, 2007

  17. Excellent teachers,Tianjin Medical University, Tianjin, China, 1999

 

Professional Service

Committee member of the Chemotherapeutic Pharmacology Society of the Chinese Pharmacological Society

Reviewer for:

Journal of Medicinal Chemistry

European Journal of Medicinal Chemistry

Inorganic Chemistry Frontiers

Chemical Communications

Journal of Materials Chemistry B

Journal of Inorganic Biochemistry

Inorganic Chemistry

Dalton Trans.

Analyst

 

Membership of Academic Society

Pharmaceutical Society of China

Chemistry Society of China

 

Books

Inorganic Chemistry (Chinese), People's Medical Publishing House(PMPH), ISBN 978-7-117-22036-1, Associate editor, 2016.

Activating Unreactive Substrates, WILEY-VCH, ISBN 978-3-527-31823-0, 2009.



Publications

  1. Xue-Qing Song,1 Rui-Ping Liu,1 Shu-Qing Wang,1 Zhe Li, Zhong-Ying Ma, Ran Zhang, Cheng-Zhi Xie, Xin Qiao, and Jing-Yuan Xu*. Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response In Vivo. Journal of Medicinal Chemistry, 2020, 63(11), 6096–6106.

  2. Ran Zhang, Xue-Qing Song, Rui-Ping Liu, Zhong-Ying Ma, and Jing-Yuan Xu*. Fuplatin: an Efficient and Low-toxic Dual-prodrug. Journal of Medicinal Chemistry, 2019,62(9), 4543–4554.

  3. Xin Qiao1, Yu-Yang Gao1, Li-Xia Zheng, Xiao-Jing Ding, Ling-Wen Xu, Juan-Juan Hu, Wei-Zhen Gao**, Jing-Yuan Xu*. Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate. European Journal of Medicinal Chemistry, 2021, 223, 113730.

  4. Zhong-Ying Ma1, Xue-Qing Song1, Juan-Juan Hu1, Dong-Bo Wang, Xiao-Jing Ding , Rui-Ping Liu, Miao-Liang Dai, Fan-Yin Meng, Jing-Yuan Xu*. Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment. Biochemical Pharmacology, 2021, 188, 114523.

  5. Xue-Qing Song1, Zhong-Ying Ma1, Yi-Gang Wu1, Miao-Liang Dai, Dong-Bo Wang, Jing-Yuan Xu*, Yangzhong Liu*. New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo. European Journal of Medicinal Chemistry,2019, 167, 377–387.

  6. Zhong-Ying Ma1, Dong-Bo Wang1, Xue-Qing Song1, Qian Chen, Yi-Gang Wu, Chun-Lai Zhao, Jing-Yi Li, Shi-Hao Cheng, Jing-Yuan Xu*. Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo. European Journal of Medicinal Chemistry, 2018, 157, 1292–1299.

  7. Xue-Qing Song1, Ya-Hong Liu1, Jia Shao1, Zhen-Lei Zhang, Cheng-Zhi Xie, Xin Qiao, Wei-Guo Bao*, Jing-Yuan Xu*. Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone. European Journal of Medicinal Chemistry, 2018, 157, 188–197.

  8. Zhen-Lei Zhang1, Chun-Lai Zhao1, Qian Chen, Kai Xu, Xin Qiao**, Jing-Yuan Xu*.Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent. European Journal of Medicinal Chemistry, 2018,155, 434–444.

  9. Xiao-Jing Yan1, Zhe Li1, Hai-Bo Liu1, Zhi-Gang Wang, Jing Fan, Cheng-Zhi Xie*, Qing-Zhong Li, Jing-Yuan Xu*. A chromone hydrazide Schiff base fluorescence probe with high selectivity and sensitivity for the detection and discrimination of human serum albumin (HSA) and bovine serum albumin (BSA). Journal of Photochemistry and Photobiology A: Chemistry, 2021, 113576.

  10. Liao, Wen-Hui, Song, Xue-Qing, Kong, Yan-Jie, Bao, Rui-Dan, Li, Fang-Fang, Zhou, Jie, Zhao, Qi-Hua, Xu, Jing-Yuan*, Xie, Ni*, Xie, Ming-Jin*. A novel Schiff base cobalt(III) complex induces a synergistic effect on cervical cancer cells by arresting early apoptosis stage. Biometals, 2021, 34, 277–289.

  11. Yong-Po Zhang1, Zhong-Ying Ma1, Pei-Pei Qiao, Chun-Yan Gao*, Jin-Lei Tian*, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu*, Shi-Ping Yan. Design and biological evaluations of mono- and di-nuclear copper(II) complexes: Nuclease activity, cytotoxicity and apoptosis. Polyhedron, 2021, 193, 114880.

  12. Xiao-Jing Yan, Yu-Yang Gao, Hai-Bo Liu, Xin Qiao, Cheng-Zhi Xie*, Qing-Zhong Li, Wei-Zhen Gao, Hua-Bing Sun*, Jing-Yuan Xu*. A novel double target fluorescence probe for Al3+/Mg2+ detection with distinctively different responses and its applications in cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 261 (2021) 120067.

  13. Yong-Po Zhang, Zhong-Ying Ma, Pei-Pei Qiao, Chun-Yan Gao*, Jin-Lei Tian*, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu*, Shi-Ping Yan. Copper based metallonucleases as potential antitumor drugs: Synthesis, Structure, in vitro Cytotoxicity and Apoptosis inducing properties, Journal of Molecular Structure, 2021, 1236, 130278.

  14. Xiao-Jing Ding,1 Ran-Zhang,1 Rui-Ping Liu,1 Xue-Qing Song, Xin Qiao, Cheng-Zhi Xie, Xiu-He Zhao, Jing-Yuan Xu*. A class of Pt(IV) triple-prodrugs targeting nucleic acid, thymidylate synthase and histone deacetylases,Inorg. Chem. Front., 2020, 7, 1220–1228.

  15. Ming Liu,1 Xue-Qing Song,1 Yuan-Di Wu, Jing Qian*,Jing-Yuan Xu*,Cu(II)-TACN complexes selectively induced antitumor activities in HepG-2 cells in vitro by ROS-mediated mitochondrial and DNA damage, Dalton Trans., 2020, 49, 114–123.

  16. Zhi-Gang Wang1, Xiao-Jing Ding1, Yu-Ying Huang, Xiao-Jing Yan, Bin Ding Qing-Zhong Li, Cheng-Zhi Xie**, Jing-Yuan Xu* The development of coumarin Schiff base system applied as highly selective fluorescent/colorimetric probes for Cu2+ and tumor biomarker glutathione detection. Dyes and Pigments, 2020, 175, 108156–58.

  17. Rui-Dan Bao1, Xue-Qing Song1, Yan-jie Kong1, Fang-Fang Li, Wen-Hui Liao, Jie Zhou, Ji-hong Zhang, Qi-Hua Zhao, Jing-Yuan Xu*, Ce-shi Chen*, Ming-Jin Xie*. A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms. Journal of Inorganic Biochemistry, 2020, 208, 111103.

  18. Xue-Qing Song, Zhi-Gang Wang, Yang Wang, Yu-Ying Huang, Yu-Xuan Sun, Yan Ouyang, Cheng-Zhi Xie*andJing-Yuan Xu*. Syntheses, characterization, DNA/HSA binding ability, and antitumor activities of a family of isostructural binuclear lanthanide complexes containing hydrazine Schiff base. Journal of Biomolecular Structure and Dynamics, 2020, 38(3), 733–743.

  19. Zhi-Gang Wang, Hai-Bo Liu, De-Long Zhang, Wei Liu, Cheng-Zhi Xie*, Qing-Zhong Li, Jing-Yuan Xu*, A novel hydrazide Schiff base self-assembled nanoprobe for selective detection of human serum albumin and its applications in renal disease surveillance, Journal of Materials Chemistry B, 2020, 8, 8346–8355.

  20. Ling-Wen Xu1, Xin-Tian Wang1, Yun-Hong Zou, Xu-Ya Yu, Cheng-Zhi Xie, Xin Qiao*, Qing-Zhong Li, Jing-Yuan Xu*. Novel 2-hydroxynaphthalene-based fluorescent turn-on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo, Appl. Organometal. Chem.2020, e5812.

  21. Jia Shao,‡ Qiang Zhang,‡ Jing Wei, Zhiguang Yuchi, Peng Cao, Shao-Qing Li, Shan Wang, Jing-Yuan Xu, Shuang Yang, Yi Zhang,* Jin-Xia Wei* and Jin-Lei Tian*. Synthesis, crystal structures, anticancer activities and molecular docking studies of novel thiazolidinone Cu(II) and Fe(III) complexes targeting lysosomes: special emphasis on their binding to DNA/BSA. Dalton Trans., 2021, 50(38):13387–13398.

  22. Xiao-Jing Yan, Zhi-Gang Wang, Yang Wang, Yu-Ying Huang, Hai-Bo Liu, Cheng-Zhi Xie*, Qing-Zhong Li, Jing-Yuan Xu*. A dual-functional fluorescent probe for sequential determination of Cu2+/S2- and its applications in biological systems. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 243, 118797.

  23. Zhi-Gang Wang, Yang Wang, Xiao-Jing Ding, Yu-Xuan Sun, Hai-Bo Liu, Cheng-Zhi Xie*, Jing Qian, Qing-Zhong Lie, Jing-Yuan Xu*. A highly selective colorimetric and fluorescent probe for quantitative detection of Cu2+/Co2+: The unique ON-OFF-ON fluorimetric detection strategy and applications in living cells/zebrafish. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228, 117763.

  24. Yue Liu†, Xue-Qing Song†, Si-Tong Li, Xin Liu, Jin-Lei Tian*, Jing-Yuan Xu*, Shi-Ping Yan, Three pairs of enantiomers bearing mitochondria-targeted TPP+ groups as potential anti-cancer agents. Appl. Organometal. Chem. June2019, 33(6), e4920.

  25. Yang Wang, Zhi-Gang Wang, Xue-Qing Song, Qian Chen, He Tian, Cheng-Zhi Xie*, Qing-Zhong Li, Jing-Yuan Xu*. Dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: solvent-controlled recognition effect and bio-imaging application. Analyst, 2019, 144, 4024–4032.

  26. Yi-Gang Wu1, Dong-Bo Wang1, Juan-Juan Hu, Xue-Qing Song, Cheng-Zhi Xie, Zhong-Ying Ma* and Jing-Yuan Xu*. An iron(III) complex selectively mediated cancer cell death: crystal structure, DNA targeting and in vitro antitumor activities[J]. Inorg. Chem. Front., 2019, 6, 1040–1049.

  27. He Tiana1, XinQiaoa1, Zhen-Lei Zhanga, Cheng-Zhi Xiea, Qing-Zhong Lib, Jing-Yuan Xu*. A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 207, 31–38.

  28. Jia Shao*,Jin-Xia Wei, Yi Zhang, Jing-Yuan Xu*. Spectroscopic investigations of the interactions of potential antitumor amino-thiazolidinone platinum(II) compounds with human serum albumin. Inorganic Chemistry Communications, April 2019, 102, 35–39.

  29. Yang Wang, Zhong-Ying Ma, De-Long Zhang, Jia-Li Deng, Xiong Chen, Cheng-Zhi Xie*, Xin Qiao, Qing-Zhong Li,Jing-Yuan Xu*.Highly selective and sensitive turn-on fluorescent sensor for detection of Al3+ based on quinoline-base Schiff base. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 195, 157–164.

  30. Jing-Jing Suo1, Zhong-Ying Ma1, Jing-Yuan Xu, Jin-Lei Tian* and Xin Liu. Preparation, characterization and biological evaluation of two chiral binuclear copper(II) complexes. Appl. Organometal. Chem.2018, 32, e3911.

  31. Xu-Dong Lin, Ya-Hong Liu1, Cheng-Zhi Xie, Wei-Guo Bao, Jun Shen* and Jing-Yuan Xu*. Three Pt(II) complexes based on Thiosemicarbazone: synthesis, HSA interaction, cytotoxicity, apoptosis and cell cycle arrest. RSC Advances, 2017, 7, 26478–26486.

  32. Zhong-Ying Ma1, Zheng Qiao1, Ang Li, Ya-Hong Liu, Cheng-Zhi Xie, Zhao-Yan Qiang, Jing-Yuan Xu*. A new mixed-ligand copper(II) complex inhibits growth and induces apoptosis by DNA targeting in human epithelial cervical cancer cells. Appl. Organometal. Chem. 2017, 31(7), e3651.

  33. He Tian1, Xin Qiao1, Cheng-Zhi Xie, Yan Ouyang*, Jing-Yuan Xu*. Synthesis, Characterization, and Magnetochemical Properties of Two Mn4 Clusters Derived from 2-Pyridinecarboxaldehyde Schiff Base Ligands.Journal of Coordination Chemistry, 2017, 70(7), 1207–1220.

  34. Wen-Jing Lian,1 Xin-Tian Wang,1 He Tian, Xue-Qing Song, Xin Qiao,* Cheng-Zhi Xie, and Jing-Yuan Xu*. Mixed-ligand copper(II) Schiff base complexes: the role of co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Trans., 2016, 45, 9073–9087.

  35. Yan Ouyang1, Xiao-Fei Zhao1, Xin Qiao, Ran Zhang, Wei-Guo Bao, Cheng-Zhi Xie, Jing-Yuan Xu*. A mononuclear nickel(II) complex based on polypyridyl ligand: synthesis, characterization and biological activity. Journal of Coordination Chemistry, 2016, 69(3), 475–484.

  36. Ya-Hong Liu1, Ang Li1, Jia Shao, Xue-Qing Song, Cheng-Zhi Xie, Wei-Guo Bao, Jing-Yuan Xu*. Four Cu(II) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity. Dalton Trans., 2016, 45, 8036–8049.

  37. Xu-Dong Lin, Biao Peng, Shao-Yong Li, Qing-Zhong Li, Cheng-Zhi Xie,* Jing-Yuan Xu*. Novel Zn(II)-thiazolone-based Solid Fluorescent Chemosensors: Naked-eye Detection for Acid/Base and Toluene. RSC Advances, 2016, 6, 52310–52317.

  38. Chun-Lai Zhao, Li-Fu Xie, Bing Li, Xin Qiao, Cheng-Zhi Xie, Wei-Guo Bao*, Jing-Yuan Xu*. 1D Alternating Copper(II) Chain Based on Three Acetate-bridging Modes: Synthesis, Crystal Structure, DNA Binding and Magnetic Properties. Journal of Coordination Chemistry, 2016, 69(14), 2182–2192.

  39. Wei Liu1, Jia Shao1, Wen-Jing Lian, Cheng-Zhi Xie, Jing-Yuan Xu. Synthesis, Structure, DNA-binding and Magnetic Properties of Dicobalt (II/III, III/III) Complexes Based on 5-(1H-benzo[d]imidazol-2-yl)-1H-imidazole-4-carboxylic ligand. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2016,46, 1541–1546.

  40. Yong-Po Zhang, Zhong-Ying Ma, Chun-Yan Gao, Xin Qiao, Jin-Lei Tian*, Wen Gu, Xin Liu, Jing-Yuan Xu*, Jin-Zhong Zhao and Shi-Ping Yan. Two dpa-based zinc(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies. New J. Chem., 2016, 40, 7513–7521.

  41. Ang Li1, Ya-Hong Liu1, Ling-Zhi Yuan, Zhong-Ying Ma, Chun-Lai Zhao, Cheng-Zhi Xie,Wei-Guo Bao, Jing-Yuan Xu*. Association of structural modifications with bioactivity in three new copper(II) complexes of Schiff base ligands derived from 5-chlorosalicylaldehyde and amino acids. Journal of Inorganic Biochemistry, 2015, 146, 52–60.

  42. Chun-Yan Gao,1 Zhong-Ying Ma,1 Yong-Po Zhang, Si-Tong Li, Wen Gu, Xin Liu, Jin-Lei Tian,* Jing-Yuan Xu,* Jin-Zhong Zhao and Shi-Ping Yan. Four related mixed-ligand nickel(II) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity. RSC Adv., 2015, 5, 30768–30779.

  43. Zhong-Ying Ma1, Jia Shao1, Wei-Guo Bao, Zhao-Yan Qiang and Jing-Yuan Xu*. A thiosemicarbazone copper(II) complex as a potential anticancer agent. Journal of Coordination Chemistry, 2015, 68(2), 277–294.

  44. Xiao-Tong Zhang, Zhong-Ying Ma, Chuan Zhao, Cheng-Zhi Xie*, Jing-Yuan Xu*. Synthesis, crystal structures, DNA binding and cytotoxicity activities of two copper(II) complexes based on unsymmetrical tripodal ligands. Journal of Coordination Chemistry, 2015, Vol. 68(13), 2307–2323.

  45. Jia Shao1, Zhong-Ying Ma1, Ang Li, Ya-Hong Liu, Cheng-Zhi Xie, Zhao-Yan Qiang, Jing-Yuan Xu*. Thiosemicarbazone Cu(II) and Zn(II) Complexes as Potential Anticancer Agents: Syntheses, Crystal Structure, DNA Cleavage, Cytotoxicity and Apoptosis Induction Activity. Journal of Inorganic Biochemistry, 2014, 136, 13–23.

  46. Xin Qiao, Zhong-Ying Ma, Jia Shao, Jing-Yuan Xu*, Zhao-Yan Qiang, Jian-Shi Lou* and Wei-Guo Bao. Biological evaluation of a cytotoxic 2-substitued benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells. Biometals,2014, 27:155–172.

  47. Jia Shao, Wei-Guo Bao, He Tian, Bing Li, Xiao-Fei Zhao, Xin Qiao,Jing-Yuan Xu*.Nuclease activity and protein-binding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex. Dalton Trans., 2014, 43, 1663–1671.

  48. Xiao-Fei Zhao,1 Yan Ouyang,1 Qiang Ge, Ling-Zhi Yuan, He Tian, Qiao-Juan Su, Cheng-Zhi Xie and Jing-Yuan Xu*. Two Polypyridyl Copper(II) Complexes: Synthesis, Crystal Structure and Interaction with DNA and Serum Protein in vitro.New J. Chem., 2014, 38, 955–965.

  49. Ling-Zhi Yuan, Qiang Ge, Xiao-Fei Zhao, Yan Ouyang, Shao-Hua Li, Cheng-Zhi Xie & Jing-Yuan Xu*. Syntheses, Crystal Structures, and DNA Bindings of Co(III) and Ni(II) Complexes Based on 2,6-Bis(benzimidazol-2-yl)-4-hydroxypyridine Ligand. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2014, 44(8), 1175–1182.

  50. Cheng-Zhi Xie, Meng-Meng Sun, Shao-Hua Li, Xiao-Tong Zhang, Xin Qiao, Yan Ouyang, Jing-Yuan Xu*. Synthesis, characterization, DNA interaction, cytotoxicity and apoptosis induction of a mixed-ligand copper(II) complex. Journal of Coordination Chemistry, 2013, 66(22), 3891–3905.

  51. Jia Shao, Qiang Ge, Yan Ouyang, Cheng-Zhi Xie, Xiao-Tong Zhang, Jing-Yuan Xu*, Yves Journaux. Scalene-tricopper(II) bridged by 5-(1H-benzo[d]imidazol-2-yl-1H-imidazole-4- carboxylic acid): Synthesis, crystal structure and magnetic properties.Inorganic Chemistry Communications, 2013,36, 224–226.

  52. Yan Ouyang, Cheng-Zhi Xie, Jing-Yuan Xu*, Li Yu, Mei-Ling Zhang, Dai-Zheng Liao. Three cobalt (II) complexes with triethylenetetraaminehexaacetic acid: From binuclear complex to 3d-4f coordination polymers. Inorganic Chemistry Communications, 2013, 27, 166–170.

  53. Bing Li, Wei Liu, Jia Shao, Chun-Lan Xue, Cheng-Zhi Xie, Yan Ouyang & Jing-Yuan Xu*.Synthesis, structure, spectroscopic, and DNA binding properties of Co(III) and Ni(II) complexes with ((E)-2-(amino((pyridin-2-ylmethylene)amino)methylene)maleonitrile), Journal of Coordination Chemistry, 2013, 66(14), 2465–2476.

  54. Jing-Yuan Xu*, Hai-Bin Song, Gong-Feng Xu, Xin Qiao, Shi-Ping Yan, Dai-Zheng Liao, Yves Journaux and Joan Cano. A New Enneanuclear Nickel(II) Cluster with a Rectangular Face-Centered Trigonal Prism Structure and Cluster Glass Behavior. Chem. Commun., 2012, 48, 1015–1017.

  55. Fei Xue, Cheng-Zhi Xie, Yan-Wen Zhang, Zheng Qiao, Xin Qiao, Jing-Yuan Xu*, Shi-Ping Yan. Two new dicopper(II) complexes with oxamido-bridged ligand: Synthesis, crystal structures, DNA binding/cleavage and BSA binding activity. Journal of Inorganic Biochemistry, 2012, 115, 78–86.

  56. Zhong-Ying Ma, Cheng-Zhi Xie, Xin Qiao, Jia Shao, Jing-Yuan Xu*, Zhao-Yan Qiang, Jian-Shi Lou Activities of a novel Schiff Base copper(II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway. Journal of Inorganic Biochemistry, 2012,117, 1–9.

  57. Qiao-Juan Su, Zhong-Ying Ma, Yan Ouyang, Yan-Wen Zhang, Cheng-Zhi Xie, Jing-Yuan Xu*. Synthesis, Structure, and Photoluminescent Property of a Novel 2D Silver(I) Polymer Based on Short Ag-Ag Interactions. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2012, 42:4, 493–497.

  58. Gao C.-Y., Qiao X., Ma X.-Y., Wang Z.G., Lu J., Tian J.-L.*, Xu J.-Y., Yan S.-P.*Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes.Dalton Trans., 2012, 41, 12220.

  59. Chen G. J., Qiao X., Gao C. Y., Xu G. J., Wang Z. G., Tian J. L.*, Xu J. Y., Gu W., Liu X., YanSynthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes. J. Inorg. Biochem., 2012, 106, 90.

  60. Gong-Jun Chen, Xin Qiao, Pei-Qi Qiao, Guang-Jun Xu, Jing-Yuan Xu, Jin-Lei Tian, Wen Gu, Xin Liu and Shi-Ping Yan. Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper(II) complexes, Journal of Inorganic Biochemistry, 2011, 105, 119–126.

  61. Xin Qiao, Zhong-Ying Ma, Fei Xue, Cheng-Zhi Xie, Jing-Yuan Xu*, Zhao-Yan Qiang, Jian-Shi Lou, Gong-Jun Chen, Shi-Ping Yan. Study on potential antitumor mechanism of a novel Schiff Base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity, Journal of Inorganic Biochemistry, 2011, 105, 728–737.

  62. Yan­-Zhao Liu, Qiao-­Juan Su, Xin Qiao, Cheng-­Zhi Xie, Yan Ouyang, Jing-­Yuan Xu*, Dai-­Zheng Liao, and Shi-­Ping Yan. Syntheses, Crystal Structures and Magnetic Properties of 4,4'­Bipyridine Bridged Dinuclear MnII and NiII Complexes with the Ligand BMA [BMA = N,N­bis(benzimidazol­ 2­yl­methyl)amine], Z. Anorg. Allg. Chem., 2010, 636, 600–604.

  63. Qi-Ji Zhou, Xue-Jun Yao, Lan-Fang Hao, Yan Ouyang, Jing-Yuan Xu*, Cheng-Zhi Xie, Jian-Shi Lou, Synthesis, Crystal Structure, and Magnetic Properties of a New 2D Copper(II) Polymer Constructed by u1,5-Dicyanamide and Sulfonate Anion Bridges, Z. Anorg. Allg. Chem., 2010, 636, 2487–2491.

  64. Jing-Yuan Xu*, Cheng-Zhi Xie, Fei Xue, Lan-Fang Hao, Zhong-Ying Ma, Dai-Zheng Liao, and Shi-Ping Yan, Directed Assembly and Characterization of 1D Polymers Based on [MII(BMA)]2+ Node (M = Cu, Mn, Ni and Zn; BMA = N,N-bis (benzimidazol-2-yl-methyl)amine) with Linear Bridging Dicyanamide and Terephthalate Ligands, Dalton Trans.,2010, 39, 7159-7166.

  65. Qiao-Juan Su, Shao-Hua Li, Li Wang, Cheng-Zhi Xie, Yan Ouyang, Jing-Yuan Xu*,Synthesis，structure and characterization of 1D threefold-bridging copper(II) chain with strong ferromagnetic coupling, Inorg. Chem. Commun.,2010, 13, 1210–1212.

  66. Thomas Nebe, Jing-Yuan Xu, Alexander Beitat, Christian Würtele, Olaf Walter, Michael Serafin and Siegfried Schindler, Iron and Cobalt complexes with the ligand (2-aminoethyl)bis(2-pyridylmethyl)amine (uns-penp) and derivatives,Inorganica Chimica Acta, 2010, 363, 2965–2970.

  67. Chengzhi Xie, Qiaojuan Su, Shaohua Li, Jingyuan Xu*, Liya Wang, A novel helical chainlike nickel(II) coordination polymer containing 1D trigonal channels with water molecule guests, Inorganic Chemistry Communications, 2010,13, 1476–1479.

  68. Cheng-Zhi Xie, Yan-Zhao Liu, Qiao-juan Su, Yan Ouyang, Jing-Yuan Xu*. A dinuclear nickel(II) complex with dissimilar bridges: synthesis, crystal structure, and magnetic characterization, J. Coord. Chem. 2010, 63(5), 801–808.

  69. Gong-Jun Chen, Xin Qiao, Jin-Lei Tian, Jing-Yuan Xu, Wen Gu, Xin Liu and Shi-Ping Yan. Synthesis, DNA binding, photo-induced DNA cleavage and cytotoxicity studies of europium(III) complexes.Dalton Trans.,2010, 39, 10637–10643.

  70. Qi-Ji Zhou, Yan-Zhao Liu, Run-Ling Wang, Jing-Wei Fu, Jing-Yuan Xu*, Jian-Shi Lou. Synthesis, Crystal Structure and Magnetic Properties of Trinuclear CuII-Pyrazolate Complex Containing m3-OH, J. Coord. Chem. 2009, 62(2), 311–318.

  71. Cheng-Zhi Xie,Qi-Ji Zhou,Jing-Yuan Xu*. A New 3-D Gd(III) Coordination Polymer Constructed with Mixed Aromatic Acid: Synthesis, Structural Characterization and Magnetic Characterization. Journal Chemical Crystallography, 2009, 39, 799–803.

  72. Cheng-Zhi Xie, Xin Qiao, Fei Xue and Jing-Yuan Xu*, Poly[bis(µ3-5’-carboxy-2,2’-bipyridine-5-carboxylato-κ4O:N,N’:O’)lead(II)], Acta Crystallographica Section C, 2009, C65, m491–m493.

  73. Jing-Yuan Xu, Xin Qiao, Hai-Bin Song, Shi-Ping Yan, Dai-Zheng Liao, Song Gao, Yves Journaux and Joan Cano. Self-assembly and magnetic properties of a Ni(II)8(m4-hydroxo)6 cube with m2-Pyrazolate as exogeneous anchillary ligand, Chem. Commun., 2008, 6414–6416.

  74. Jing-Yuan Xu, Jin-Lei Tian, Qing-Wei Zhang, Jing Zhao, Shi-Ping Yan, Dai-Zheng Liao. “Tetranuclear Pyrophosphate-Bridged Cu(II) Complex with 2,2’-Dipyridylamine: Crystal Structure, Spectroscopy and Magnetism” Inorg. Chem. Commun., 2008, 11, 69–72.

  75. Jing-Yuan Xu, Bin Zhao, He-Dong Bian, Wen Gu, Shi-Ping Yan, Peng Cheng,Dai-Zheng Liao, and Pan-Wen Shen  “Syntheses, Structures and Properties of Novel Cage-Like Complexes Based on Dodecanuclear Lanthanide with a Large Cavity” Crystal Growth & Design2007, Vol.7, No.6, 1044–1048.

  76. Jing-Yuan Xu,Jin-Lei Tian, He-Dong Bian, Shi-Ping Yan, Dai-Zheng Liao, Peng Cheng and Pan-Wen Shen. “Synthesis, magnetic property and DNA cleavage behavior of a new dialkoxo-bridged diiron(III) complex” Appl. Organometal. Chem. 2007, 21, 129–134.

  77. Simon Foxon, Jing-Yuan Xu, Sabrina Turba, Michael Leibold, Frank Hampel, Frank W. Heinemann, Olaf Walter, Christian Würtele, Max Holthausen, and Siegfried Schindler. “Syntheses, Characterization and Reactivity of Iron(II), Nickel(II), Copper(II) and Zinc(II) Complexes of the Ligand N,N,N’,N’-Tetrakis(2-pyridylmethyl)-benzene-1,3-diamine (1,3-tpbd) and Its Phenol Derivative 2,6-Bis[bis(2-pyridylmethyl) amino]-p-cresol (2,6-tpcd)” Eur. J. Inorg. Chem.2007, 429–443.

  78. Jing-Yuan Xu, Simon Foxon, Michal Leibold Frank Hampel, Frank Heinemann, Olaf Walter and Siegfried Schindler. “Iron(III) Complexes with the Ligands N’,N’-bis[(2-pyridyl)methyl]ethylene diamine (uns-penp) and the Amide N-Acetyl-N’,N’-bis[(2-pyridyl)methyl]ethylenediamine (acetyl-uns-penp)”. Eur. J. Inorg. Chem. 2006, 1601–1610.

  79. He-Dong Bian, Jin-Lei Tian, Zhan-Quan Liu, Wen Gu, Jing-Yuan Xu, Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang, and Peng Cheng,Synthesis, Crystal Structure, and Properties of a Binuclear Copper(II) Complex Containing an Oxalate Bridge, Z. Anorg. Allg. Chem., 2004, 630, 327–330.

  80. Jing-Yuan Xu, Wen Gu, He-Dong Bian, Shi-Ping Yan, Peng Cheng, Dai-Zheng Liao,    Zong-Hui Jiang, Pan-Wen Shen. “1D Zigzag coordination Polymer [Cu(tacn)(4,4’-bipy)]n·(ClO4)2n (tacn = 1,4,7-triazacyclononane): Structure, Spectroscopic Characterization and Magnetic Properties”  Inorg. Chem. Commun., 2003, 6, 513–516.

  81. Jing-Yuan Xu, He-Dong Bian, Qing-Lun Wang, Shi-Ping Yan, Dai-Zheng Liao, Pan-Wen Shen. “Synthesis, Crystal Structure and Properties of [Mn(hdpa)2(N(CN)2)2] and [Co(hdpa)2(N(CN)2)2] (hdpa = 2,2’-dipyridylamine)” Z. Anorg. Allg. Chem., 2003, 629, 1063–1067.

  82. Jing-Yuan Xu, Wen Gu, Ling Li, Shi-Ping Yan, Peng Cheng, Dai-Zheng Liao, Zong-Hui Jiang. “Synthesis and crystal structure of nickel complex of N,N-bis(benzimidazol-2-yl- methyl)amine” J. Mol. Struct. 2003, 644(1-3) 23–27.

  83. Jing-Yuan Xu, He-Dong Bian, Wen Gu, Shi-Ping Yan, Peng Cheng, Dai-Zheng Liao, Zong-Hui Jiang, Pan-Wen Shen. “X-ray structural and spectroscopic studies of a mononuclear nickel(II) complex with tris(2-pyridylmethyl)amine and thiocyanate” J. Mol. Struct. 2003, 646(1-3) 237–242.

  84. He-Dong Bian, Wen Gu, Jing-Yuan Xu, Fang Bian, Shi-Ping Yan, Dai-Zheng Liao, etc. “The First μ3-oxalato-bridged Copper Complex with Tridentate Schiff Base Ligand N-ethyl-N’-salicylidene-1,2- diaminoethane: Synthesis, Structure and Magnetic Properties” Inorg. Chem. 2003, 42, 4265–4267.

  85. He-Dong Bian, Jing-Yuan Xu, Wen Gu, Shi-Ping Yan , Peng Cheng, Dai-Zheng Liao, Zong-Hui Jiang. “Synthesis, X-ray structure and magnetic properties of trinuclear copper(II) tridentate Schiff base complexes containing a partial cubane Cu3O4 core” Polyhedron, 2003, 22(21).

  86. He-Dong Bian, Jing-Yuan Xu, Wen Gu, Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang, Peng Cheng. Synthesis, structure and properties of terephthalate-bridged copper(II) polymeric complex with zigzag chain.  Inorg. Chem. Commun. 2003, 6, 573–576.

  87. Wen Gu, He-Dong Bian, Jing-Yuan Xu, Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang. Hydrothermal syntheses, structure, spectroscopic and magnetic properties of a hexanuclear cluster: [{Mn(2, 2-bipy)2}2V4O12]” Inorg. Chem. Commun. 2003, 6, 217–220.

  88. Wen Gu, He-Dong Bian, Jing-Yuan Xu, Zhan-Quan Liu, Peng Cheng Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang. “A new l1;5-dicyanamide bridged cyclic tetranuclear copper(II) complex with 1,5,9-triazacycledodeca” Inorg. Chem. Commun.2003,6, 966–970.

  89. He-Dong Bian, Jing-Yuan Xu, Wen Gu, Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang, Peng Cheng. “Synthesis and 2D H-bonded Cd(Ⅱ)…” Chinese J. Struct. Chem. 2003,22(6), 710–712.

  90. He-Dong Bian, Jing-Yuan Xu, Wen Gu, Shi-Ping Yan, Dai-Zheng Liao, Zong-Hui Jiang. Bis(N,N'-dimethylethylenediamine)-copper(II) oxalate dihydrate: Acta Crystallographica Section E: 2003, 59, M441–M442.

 

1.      

 

Grant

Ongoing:

  1. Natural Science Foundation of China (No. 21977080), 01/2020-12/2023, RMB 660,000.

 

Completed:

  1. Natural Science Foundation of China (No. 21371135), 01/2014-12/2017, RMB 800,000.

  2. Natural Science Foundation of China (No. 20971099), 01/2010-12/2012, RMB 350,000.

  3. Key Natural Science Foundation of Tianjin(No. 17JCZDJC33100), 04/2017-03/2020, RMB 200,000.

  4. Key Natural Science Foundation of Tianjin (No. 13JCZDJC28200), 04/2013-03/2016, RMB 200,000.

  5. Young and middle aged key innovative talents of Tianjin, China, 2012, RMB 450,000.