Ying Chen, Ph.D.

Ying Chen, PhD

Instructor

School of Pharmacy

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone:

Email: chenyingweixiao37@163.com

Education

Bachelor China Pharmaceutical University, Nanjing, China, 2001

Ph.D.       China Pharmaceutical University, Nanjing, China, 2010

Professional Experience

2018-Now    Instructor, School of Pharmacy, Tianjin Medical University, Tianjin, China

2010-2018    Instructor, Basic medical research center, Tianjin Medical University, Tianjin, China

Research Interest

Study on pharmacodynamic material basis and mechanism of natural products in anti-metabolic syndrome

  Publication

1. Jiangping Nie; Zhenni Qu; Ying Chen; Jiahao Chen; Yue Jiang; Meina Jin; Yang Yu; Wenyan Niu;   Hongquan Duan*;Nan Qin*.Discovery and anti-diabetic effects of novel isoxazole based flavonoid derivatives, Fitoterapia, 2020. 142(104499).

2. Ying Chen; Feng-Bo Cheng; Xiao-Ran Wu; Wen Zhu; Jian-Wen Liao; YueJiang; Chang Zhang; Wen-Yan Niu; Yang Yu; Hong-Quan Duan*; Nan Qin*; Flavonoid derivatives synthesis and anti-diabetic activities, Bioorganic Chemistry. 2019, 95 (103501)

3. Chang Zhang, Yue Jiang, Jia Liu, Meina Jin, Nan Qin, Ying Chen, Wenyan Niu, Hongquan Duan*. AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells. Drug Des Devel Ther. 2018, 12: 1581-1587.

4. Ying Chen, Chang Zhang, MeiNa Jin, Nan Qin, Wei Qiao, Xiaolong Yue, Hongquan Duan*, Wenyan Niu*. Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice. Natural Product Research. 2016, 30 (17):1988-1992.

5. Nan Qin #, Ying Chen #(co-first author), Meina Jin, Chang Zhang, Wei Qiao, Xiaolong Yue, Hongquan Duan*, Wenyan Niu*. Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice.Eur J Pharm Sci. 2016,82:52-63.

6. Ying Chen, Lili Ji, Aizhen Xiong, Li Yang, Zhengtao Wang *.Involvement of intracellular glutathione in regulating isoline-induced cytotoxicity in human normal liver L-02 cells. Toxicol Ind Health. 2013,29(6):567-575.

7. Ying Chen, Lili Ji, Tianyu Liu, Zhengtao Wang *.Evaluation of gender-related differences in various oxidative stress enzymes in mice. Chin J Physiol. 2011, 54(6):385-390.

8. Ying Chen, Lili Ji, HaiTao Wang, Zhengtao Wang *. Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes.Environ Toxicol Pharmacol. 2009, 28(3):357-362.

9. Lili Ji, Ying Chen, Tianyu Liu, Zhengtao Wang *. Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes.Toxicol Appl Pharmacol. 2008, 231(3):393-400.

10. Lili Ji, Ying Chen, Zhengtao Wang *.The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism.Exp Toxicol Pathol. 2008, 60(1):87-93.

11. Lili Ji, Ying Chen, Zhengtao Wang *.Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes.Environ Toxicol Pharmacol. 2008, 26(3):331-335.

12.  Lili Ji, Ying Chen, Zhengtao Wang *.Intracellular glutathione plays important roles in pyrrolizidine alkaloid clivorine-induced toxicity on L-02 hepatocytes.Toxicol Mech Methods. 2008, 18(8):661-664.

13. Kaikai Shen, Lili Ji, Ying Chen, Qianming Yu, Zhengtao Wang *.Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice.Biosci Trends. 2011, 5(1):30-37.

14.  Lili Ji, Tiaoyu Liu, Ying Chen, Zhengtao Wang *.Protective mechanisms of N-acetyl-;cysteine again pyrrolizidine alkaloid clivorine-induced hepatotoxicity.[J]. Journal of Cellular Biochemistry, 2010, 108(2):424-432.

15. Wen Chen, Xiao-ai Shou, Ying Chen, Nan Qin, Wei Qiao, Sheng-an Tang*, Hongquan Duan*. A New Aurone from Smilax riparia. Chemistry of Natural Compounds.2014, 50 (6), 989-993.

    
    

Grant

Natural Science Foundation of China:  Study on the effect and molecular mechanism of flavonoid derivative C45 on nonalcoholic fatty liver (Grant number: 82003825) 2021.01 - 2023.12