Yang Yu, Ph.D.

Yang Yu, PhD

Lecture

School of Pharmacy

Tianjin Medical  University

22 Qixiangtai Road

Tianjin 30000780

Phone: +86-22-83336538

Email: yuyang@tmu.edu.cn

Education

B.S.     Shenyang Pharmaceutical University, Shenyang, China, 2009

Ph.D.  Southern Illinois University Carbondale, Springfield,  IL, United States, 2014

Postdoctoral Fellow   Stanford University, Palo Alto, CA, United States, 2014-2015

Professional Experience

2015-            Lecture, School of Pharmacy, Tianjin Medical University, Tianjin, China

Research interest

Focus on the evaluation of anti-tumor effect of active compounds from nature products.

Publication

1. Ni TW, Duan XC, Wang M, Jia MQ, Chen Y, Yu Y, Qin N, Duan HQ (2021). Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis by targeting HSP90α. Bioorg Chem. 2021 Oct;115:105201. doi: 10.1016/j.bioorg.2021.105201.

2. Yin C, Tian Y, Hu L, Yu Y, Wu Z, Zhang Y, Wang X, Miao Z, Qian A (2021). MACF1 alleviates aging-related osteoporosis via HES1. J Cell Mol Med. 2021 Jun 15;25(13):6242–57. doi: 10.1111/jcmm.16579.

3. Yin C, Tian Y, Yu Y, Yang C, Su P, Zhao Y, Wang X, Zhang K, Pei J, Li D, Chen Z, Zhang Y, Miao Z, Qian A (2020). miR-129-5p Inhibits Bone Formation Through TCF4. Front Cell Dev Biol. 2020 Nov 6;8:600641. doi: 10.3389/fcell.2020.600641.

4. Li XY, Yu Y, Jia M, Jin MN, Qin N, Zhao C, Duan HQ (2016). Terminamines K-S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis. Molecules. 2016 Sep 26;21(10).

5.Gan CC, Ni TW, Yu Y, Qin N, Chen Y, Jin MN, Duan HQ(2017). Flavonoid derivative (Fla-CN) inhibited adipocyte differentiation via activating AMPK and up-regulating microRNA-27 in 3T3-L1 cells. Eur J Pharmacol. 2017 Feb 15;797:45-52.

6.Yu Y, Elble RC (2016). Homeostatic Signaling by Cell-Cell Junctions and Its Dysregulation during Cancer Progression. J Clin Med. 2016 Feb 18;5(2).

7. Ramena G, Yin Y, Yu Y, Walia V, Elble RC. CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation (2016). PLoS One. 2016 Mar 1;11(3)

8.Yu Y., Walia V & Elble, R. C. (2013). Loss of CLCA4 Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer Cells. PLoS One. 2013 Dec 26;8(12):e83943.

9.Walia, V., Yu, Y., Cao, D., Sun, M., McLean, J. R., Hollier, B. G., . . . Elble, R. C. (2012). Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis. Oncogene, 31(17), 2237-2246. doi: 10.1038/onc.2011.392

10.Yu, Y., Ramena, G., & Elble, R. C. (2012). The role of cancer stem cells in relapse of solid tumors. Front Biosci (Elite Ed), 4, 1528-1541.

Grant

Ongoing:

Investigation on the target and molecular mechanism of prognane alkaloid derivative QN66 for its inhibition on breast cancer metastasis and angiogenesis. Project supported by the National Natural Science Foundation of China (grant number 81803577).

Investigation on the molecular mechanism of a potential anti-metastatic compound QN66. Project supported by Tianjin science and technology commission for Young Scientists.