Zhong-Ying Ma, Ph.D.

Zhong-Ying Ma, PhD

Assistant Professor

School of Pharmacy

Tianjin Medical  University

22 Qixiangtai Road

Tianjin 30000780

Email: mazhongying@tmu.edu.cn

Education

MD     Tianjin Medical University, Tianjin, China, 2005-2009

Ph.D.  Tianjin Medical University, Tianjin, China, 2009-2014

Professional Experience

2014-present   Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

Research Fields

Molecular targeted anti-cancer drugs

Honors

Tianjin science and technology award (2019ZR-3-012-R4)

Tianjin Medical University science and technology award (KG18001-4)

Publication

1. Zhong-Ying Ma^#, Xue-Qing Song^#, Juan-Juan Hu^#, Dong-Bo Wang, Xiao-Jing Ding, Rui-Ping Liu, Miao-Liang Dai, Fan-Yin Meng, Jing-Yuan Xu^*. Ketoplatin in triple-negative breast cancer cells MDA-MB-231: high efficacy and low toxicity, and positive impact on inflammatory microenvironment. Biochemical Pharmacology, 2021, 188: 114523.

2. Yong-Po Zhang^#, Zhong-Ying Ma^#(co-first author), Pei-Pei Qiao, Chun-Yan Gao^*, Jin-Lei Tian^*, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu^*, Shi-Ping Yan. Copper based metallonucleases as potential antitumor drugs: Synthesis, Structure, in vitro Cytotoxicity and Apoptosis inducing properties. Journal of Molecular Structure, 2021, 1236: 130278.

3. Yong-Po Zhang^#, Zhong-Ying Ma^#(co-first author), Pei-Pei Qiao, Chun-Yan Gao^*, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu^*, Shi-Ping Yan. Design and biological evaluations of mono- and di-nuclear copper(II) complexes: Nuclease activity, cytotoxicity and apoptosis. Polyhedron, 2021, 193: 114880.

4. Yi-Gang Wu^#, Dong-Bo Wang^#, Juan-Juan Hu, Xue-Qing Song, Cheng-Zhi Xie, Zhong-Ying Ma^*, Jing-Yuan Xu^*, An Iron(III) Complex Selectively Mediated Cancer Cell Death: Crystal Structure, DNA Targeting and in vitro Antitumor Activities, Inorganic Chemistry Frontiers, 2019, 6: 1040-1049.

5. Xue-Qing Song^#, Zhong-Ying Ma^#(co-first author), Yi-Gang Wu^#, Miao-Liang Dai, Dong-Bo Wang, Jing-Yuan Xu^*, Yangzhong Liu^*, New NSAID-Pt(IV) Prodrugs to Suppress Metastasis and Invasion of Tumor Cells and Enhance Anti-Tumor Effect in vitro and in vivo, European Journal of Medicinal Chemistry, 2019, 167: 377-387.

6. Zhong-Ying Ma^#, Dong-Bo Wang^#, Xue-Qing Song^#, Yi-Gang Wu, Qian Chen, Chun-Lai Zhao, Jing-Yi Li, Shi-Hao Cheng, Jing-Yuan Xu^*, Chlorambucil-Conjugated Platinum (IV) Prodrugs to Treat Triplenegative Breast Cancer in vitro and in vivo,European Journal of Medicinal Chemistry, 2018, 157: 1292-1299.

7. Yang Wang^#,Zhong-Ying Ma^# (co-first author), De-Long Zhang,Jia-Li Deng,Xiong Chen, Cheng-Zhi Xie^*, Xin Qiao, Qing-Zhong Li,Jing-Yuan Xu^*. Highly selective and sensitive turn-on fluorescent sensor for detection of Al³⁺ based on quinoline-base Schiff base. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 195:157-164.

8. Jing-Jing Suo^#, Zhong-Ying Ma^# (co-first author), Jing-Yuan Xu, Jin-Lei Tian^*, Xin Liu. Preparation, characterization and biological evaluation of two chiral binuclear copper(II) complexes. Appl. Organometal. Chem.,2018, 32: e3911.

9. Zhong-Ying Ma^#, Zheng Qiao^#, Dong-Bo Wang, Xuan Hou, Xin Qiao, Cheng-Zhi Xie, Zhao-Yan Qiang^*,Jing-Yuan Xu^*, A Mixed-Ligand Copper (II) Complex that Inhibits Growth and Induces Apoptosis by DNA Targeting in Human Epithelial Cervical Cancer Cells, Applied Organometallic Chemistry, 2017, 31: e3651.

10. Yong-Po Zhang^#, Zhong-Ying Ma^# (co-first author), Chun-Yan Gao, Xin Qiao, Jin-Lei Tian^*, Wen Gu, Xin Liu, Jing-Yuan Xu^*, Jin-Zhong Zhao and Shi-Ping Yan. Two dpa-based zinc(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies. New J. Chem.,2016, 40: 7513-7521.

11. Zhong-Ying Ma^#, Jia Shao^#, Wei-Guo Bao, Zhao-Yan Qiang and Jing-Yuan Xu^*. A thiosemicarbazone copper(II) complex as a potential anticancer agent. Journal of Coordination Chemistry, 2015, 68(2): 277-294.

12. Chun-Yan Gao^#, Zhong-Ying Ma^# (co-first author),Yong-Po Zhang, Si-Tong Li, Wen Gu, Xin Liu, Jin-Lei Tian^*, Jing-Yuan Xu^*, Jin-Zhong Zhao and Shi-Ping Yan. Four related mixed-ligand nickel(II) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity. RSC Adv., 2015, 5: 30768-30779.

13. Jia Shao^#, Zhong-Ying Ma^# (co-first author), Ang Li, Ya-Hong Liu, Cheng-Zhi Xie, Zhao-Yan Qiang, Jing-Yuan Xu^*. Thiosemicarbazone Cu(II) and Zn(II) Complexes as Potential Anticancer Agents: Syntheses, Crystal Structure, DNA Cleavage, Cytotoxicity and Apoptosis Induction Activity. Journal of Inorganic Biochemistry, 2014, 136: 13-23.

14. Zhong-Ying Ma, Cheng-Zhi Xie, Xin Qiao, Jia Shao, Jing-Yuan Xu^*, Zhao-Yan Qiang, Jian-Shi Lou^*, Activities of A Novel Schiff Base Copper (II) Complex on Growth Inhibition and Apoptosis Induction toward MCF-7 Human Breast Cancer Cells via Mitochondrial Pathway, Journal of Inorganic Biochemistry, 2012, 117: 1-9.

Grant

Completed:

Tianjin Natural Science Foundation, Grant No. 18JCQNJC83600, 2018.10-2021.09.