Xin Qiao, Ph.D.
Xin Qiao, Ph.D.
Associate Professor
Department of Chemical Biology
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-22-83336681
Email: qiaoxin@tmu.edu.cn
Education
2004/09-2008/07 BSinPharmacy (Major) and Law (Minor), Tianjin Medical University, Tianjin, China
2008/09-2013/07 Ph.D. in Pharmacology, Tianjin Medical University, Tianjin, China (Advisors: Prof. Jian-Shi Lou and Prof. Jing-Yuan Xu)
Professional Experience
2020/09-present Deputy Director of Pharmaceutical Experiment Center, School of Pharmacy, Tianjin Medical University, Tianjin, China
2017/12-present Associate Professor, Department of Chemical Biology, School of Pharmacy, Tianjin Medical University, Tianjin, China
2013/07-2017/12 Assistant Professor, Department of Chemical Biology, School of Pharmacy,Tianjin Medical University, Tianjin, China
2011/09-2013/03 Visiting Ph.D. Student, Department of Chemistry, Wake Forest University, NC, United States (Host Supervisor: Prof. Dr. Ulrich Bierbach)
Honors
2021 Teaching Excellence Award of Tianjin Medical University
2021 Excellent Teacher of Tianjin Medical University
2020 3rd Prize of Tianjin Natural Science Award (3/5, Jing-Yuan Xu, Cheng-Zhi Xie, Xin Qiao, Zhong-Ying Ma, Yan Ouyang)
2018 First Prize of the 3rd National Young Pharmacology Teachers’ Basic Teaching Skills Competition (English Group)
2018 Member of the 5th Committee of Tianjin Heping District Youth Federation
2018 Candidate of Excellent Teacher Training Program of Tianjin Medical University
2016 Annual Excellent Class Tutor of Tianjin Medical University.
2015 First Prize of Excellent Papers of Academic Annual Meeting of Tianjin Medical University.
2014 Third Level Talent of Tianjin “131” Innovative Talents Training Program.
2012 Awardee of National Graduate Students’ Scholarship.
2011 Awardee of State Scholarship Fund by China Scholarship Council (No.2011694010).
2010 Awardee of Innovation Grant for Graduate Students of Tianjin Medical University (No.2010GSI05).
2009 Awardee of Excellent Student Cadre in Tianjin City, Tianjin, China.
Professional Service
Reviewer for:
Applied Organometallic Chemistry
Biochemical Pharmacology
European Journal of Pharmacology
Journal of Coordination Chemistry
Journal of Molecular Strucutre
Journal of Photochemistry & Photobiology, B: Biology
Materials Science & Engineering C
Metallomics
Membership of Academic Society:
Member of Chinese Pharmacological Society (CNPHARS)
Member of the Chinese Chemical Society (CCS)
Youth Committee of Chemotherapy Pharmacology Committee in Chinese Pharmacological Society
Publication
2021
[1] X Qiao#, YY Gao#, LX Zheng, XJ Ding, LW Xu, JJ Hu, WZ Gao*and JY Xu*. Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate. Eur J Med Chem 2021; 223: 113730.
[2] XJ Yan, YY Gao, HB Liu, X Qiao, CZ Xie, QZ Li, WZ Gao, HB Sun* and JY Xu*. A novel double target fluorescence probe for Al3+/Mg2+ detection with distinctively different responses and its applications in cell imaging. Spectrochim Acta A Mol Biomol Spectrosc2021; 261: 120067.
2020
[3] LW Xu#, XT Wang#, YH Zou, XY Yu, CZ Xie, X Qiao*, QZ Li and JY Xu*. Novel 2-hydroxynaphthalene-based fluorescent turn-on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo. Appl Organomet Chem 2020; 34: e5812.
2019
[4] H Tian#,X Qiao#, ZL Zhang, CZ Xie, QZ Li and JY Xu*. A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo. Spectrochim Acta A Mol Biomol Spectrosc2019; 207: 31-38.
2018
[5] ZL Zhang, CL Zhao, Q Chen, K Xu, X Qiao* and JY Xu*. Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent. Eur J Med Chem 2018; 155:434-444.
[6] XQ Song, YH Liu, J Shao, ZL Zhang, CZ Xie, X Qiao, WG Bao* and JY Xu*.Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.Eur J Med Chem 2018; 157:188-197.
[7] Y Wang, ZY Ma, DL Zhang, JL Deng, X Chen, CZ Xie*, X Qiao, and JY Xu*. Highly selective and sensitive turn-on fluorescent sensor for detection of Al3+ based on quinoline-base Schiff base. Spectrochim Acta A Mol Biomol Spectrosc 2018; 195: 157-164.
2017
[8] H Tian#, X Qiao#, CZ Xie, Y Ouyang* and JY Xu*. Synthesis, characterization, and magnetochemical properties of two Mn-4 clusters derived from 2-pyridinecarboxaldehyde Schiff base ligands. J Coord Chem 2017; 70: 1207-1220.
[9] ZY Ma#, Z Qiao#, DB Wang, X Hou, X Qiao, CZ Xie, ZY Qiang* and JY Xu*. A mixed-ligand copper(II) complex that inhibits growth and induces apoptosis by DNA targeting in human epithelial cervical cancer cells. Appl Organomet Chem 2017; 31: e3651.
2016
[10]WJ Lian, XT Wang, CZ Xie, H Tian, XQ Song, HT Pan, X Qiao* and JY Xu*. Mixed-ligand copper(II) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Trans 2016; 45: 9073-9087.
[11]YP Zhang, ZY Ma, CY Gao, X Qiao, JL Tian*, W Gu, X Liu, JY Xu*, JZ Zhao and SP Yan. Two dpa-based zinc(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies. New J Chem 2016; 40: 7531-7521.
[12]CL Zhao, LF Xie, B Li, X Qiao, CZ Xie, WG Bao, and JY Xu*. A 1-D alternating copper(II) chain based on three acetate-bridging modes: synthesis, crystal structure, DNA binding and magnetic properties. J Coord Chem 2016; 69: 2189-2192.
[13]Y Ouyang, XF Zhao, X Qiao, R Zhang, WG Bao, CZ Xie and JY Xu*. A mononuclear nickel(II) complex based on polypyridyl ligand: synthesis, characterization, and biological activity. J Coord Chem 2016; 69: 475-484.
2015
[14]M Yang, AJ Pickard, X Qiao, MJ Gueble, CS Day, GL Kucera and U Bierbach*. Synthesis, reactivity and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Inorg Chem 2015; 54: 3316-3324.
2014
[15]X Qiao, S Ding, F Liu, GL Kucera, and U Bierbach*. Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. J Biol Inorg Chem 2014; 19: 415-426.
[16]X Qiao, ZY Ma, J Shao, WG Bao, JY Xu*, ZY Qiang and JS Lou*. Biological evaluation of a cytotoxic 2-substitued benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells. Biometals 2014; 27: 155-172.
[17]J Shao, WG Bao, H Tian, B Li, XF Zhao, X Qiao, and JY Xu*. Nuclease activity and protein-biding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex. Dalton Trans 2014; 43: 1663-1671.
2013
[18]S Ding#, X Qiao#, J Suryadi, GS Marrs, GL Kucera, and U Bierbach*. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum. Angew Chem Int Ed2013; 52: 3350-3354.
[19]S Ding, X Qiao, GL Kucera and U Bierbach*. Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun 2013; 49: 2415-2417.
[20]GJ Chen, ZG Wang, X Qiao, JY Xu, JL Tian*, SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity studies of a family of heavy rare earth complexes. J Inorg Biochem 2013; 127: 39-45.
[21]CZ Xie, MM Sun, SH Li, XT Zhang, X Qiao, Y Ouyang, and JY Xu*. Synthesis, characterization, DNA interaction, cytotoxicity, and apoptosis induction of a mixed-ligand copper(II) complex. J Coord Chem 2013; 66: 3891-3905.
Before 2012
[22]X Qiao, AE Zeitany, MW Wright, AS Essader, KE Levine, GL Kucera and U Bierbach*. Analysis of the DNA damage produced by a platinum acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics 2012; 4: 645-652 (Back cover paper).
[23]S Ding, X Qiao, GL Kucera and U Bierbach*. Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. J Med Chem 2012; 55: 10198-10203.
[24]ZY Ma, X Qiao, CZ Xie, J Shao, JY Xu*, ZY Qiang and JS Lou*. Activities of a novel Schiff Base copper(II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway. J Inorg Biochem 2012; 117: 1-9.
[25]GJ Chen, X Qiao, CY Gao, GJ Xu, ZL Wang, JL Tian*, JY Xu, W Gu, X Liu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes. J Inorg Biochem 2012; 109: 90-96.
[26]CY Gao, X Qiao, ZY Ma, ZG Wang, J Lu, JL Tian*, JY Xu and SP Yan*. Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes. Dalton Trans 2012; 41: 12220-12232.
[27]JY Xu*, HB Song, GF Xu, X Qiao, SP Yan*, DZ Liao, Y Journaux* and J Cano. A new enneanuclear nickel(II) cluster with a rectangular face-centered trigonal prism structure and cluster glass behavior. Chem Commun 2012; 1015-1017.
[28]F Xue, CZ Xie, YW Zhang, Z Qiao, X Qiao, JY Xu* and SP Yan. Two new dicopper(II) complexes with oxamido-bridged ligand: Synthesis, crystal structures, DNA binding/cleavage and BSA binding activity. J Inorg Biochem 2012; 115: 78-86.
[29]X Qiao, ZY Ma, CZ Xie, F Xue, YW Zhang, JY Xu*, ZY Qiang*, JS Lou, GJ Chen and SP. Yan. Study on potential antitumor mechanism of a novel Schiff base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity. J Inorg Biochem 2011; 105: 728-737.
[30]GJ Chen, X Qiao, PQ Qiao, GJ Xu, JY Xu, JL Tian*, W Gu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper (II) complexes. J Inorg Biochem 2011; 105: 119-126.
[31]GJ Chen, X Qiao, JL Tian*, JY Xu, W Gu, X Liu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage and cytotoxicity studies of europium(III) complexes. Dalton Trans 2010; 39: 10637-10643.
[32]YZ Liu, QJ Su, X Qiao, CZ Xie, Y Ouyang, JY Xu*, DZ Liao and SP Yan*. Syntheses, crystal structures and magnetic properties of 4,4 '-bipyridine bridged dinuclear Mn-II and Ni-II complexes with the ligand BMA [BMA = N,N-bis(benzimidazol-2-yl-methyl)amine]. Z Anorg Allg Chem 2010; 636: 34.
[33]CZ Xie, X Qiao, F Xue and JY Xu*. Poly[[bis[μ3-5-carboxy-2,2’-bipyridine-5’-carboxylato -k4O:O’:N,N’] lead(II)]. Acta Cryst C 2009; m491-m493.
[34]JY Xu, X Qiao, HB Song, SP Yan*, DZ Liao, S Gao, Y Journaux* and J Cano. Self-assembly and magnetic properties of a Ni(II)8(4-hydroxo)6 cube with 2-pyrazolate as exogeneous anchillary ligand. Chem Commun 2008; 6414-6416.
Research Grants
Completed:
Tianjin Municipal Natural Science Foundation (No.17JCYBJC28500) (as P.I.)
Project: Design, Synthesis and Anticancer Activity Studies of Novel Platinum (IV) Prodrugs Based on RNA Polymerase ISelective Inhibitors.
Period: 04/01/2017−03/31/2020
National Natural Science Foundation of China (No.21401141) (as P.I.)
Project:Establishing, Biological Evaluation and Cellular Imaging of Platinum-based RNA Polymerase I Selective Inhibitors Based on a “Build-and-Click” Approach.
Period: 01/01/2014−12/31/2017
Innovation Grant for Graduate Students of Tianjin Medical University (No.2010GSI05)
Project: Study on Synthesis, Characterization and Biological Evaluation of Schiff Base Metal Complexes.
Period: 07/01/2010−06/30/2013
