Yuguang Song, Ph.D.
Yuguang Song, PhD
Associate Professor
School of Pharmacy
Tianjin Medical University
No.22 Qixiangtai Road
Heping District, Tianjin, 300070 China
Phone: 86-022-83336658 (O)
Email: songyuguang@
Website:/s/9/t/814/4e/01/info19969.htm
ORCID: 0000-0001-6271-1367
Education
B.S. Heilongjiang University, Heilongjiang, China, 1995-1999
M.S. Northeast Agricultural University, Heilongjiang, China, 1999-2002
Ph.D. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China, 2004-2007
Postdoctoral Researcher The Ohio State University, Ohio, USA, 2010-2013
Professional Experience
2002-2004 Assistant Professor, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
2013- Associate Professor, Department of Medicinal Chemistry, Tianjin Medical University, Tianjin, China
Honors
1. Excellent teacher development and support program, Tianjin Medical University, 2019
2. Excellent Stafffor School of Pharmacy, Tianjin Medical University, 2019
Professional Service
Committee member of Youth Committee, Chinese Society of Free Radical Biology and Medicine
Committee member of Youth Committee, Research Association of Modern Medical Care
Membership of Academic Society
Biophysical Society of China
Chinese Society of Chemistry
Representative Publications
1. Xinyi Cai , Alessandra Lucini Paioni, Agnes Adler, Ru Yao, Wenxiao Zhang,David Beriashvili, Adil Safeer, Andrei Gurinov, Antal Rockenbauer, Yuguang Song*,Marc Baldus* and Yangping Liu*,Highly Efficient Trityl-Nitroxide Biradicals for Biomolecular High-Field Dynamic Nuclear Polarization,Chem. Eur. J. 2021,27(50), 12758-12762.(IF 5.236)
2. Kaiyun Ji, Jinpeng Shan, Xing Wang, Xiaoli Tan, Jingli Hou, Yangping Liuand Yuguang Song*, Rational design of near-infrared fluorescent probes for superoxide anion radical: Enhancement of self-stability and sensitivity by self-immolative linker, Free Radic. Biol. Med.2021, 167, 36-44.(IF 7.934)
3. Yongfang Liao, Zizhen Ye, Meng Qian, Xing Wang, Yuda Guo, Guifang Han, Yuguang Song, Jingli Hou,* Yangping Liu,* Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications, Org. Biomol. Chem.2020, 18(28), 5473-5480. (IF 3.492)
4. Weixiang Zhai, Alessandra Lucini Paioni, Xinyi Cai, Siddarth Narasimhan, João Medeiros-Silva, Wenxiao Zhang, Antal Rockenbauer, Markus Weingarth, Yuguang Song, Marc Baldus,* Yangping Liu,* Postmodification via Thiol-Click Chemistry Yields Hydrophilic Trityl-Nitroxide Biradicals for Biomolecular High-Field Dynamic Nuclear Polarization, J. Phys. Chem. B2020, 124, 9047−9060. (IF 3.082)
5. Chengwen Li, Li Xue, Jiaxin Zhou, Yilin Zhao, Guifang Han,* Jingli Hou, Yuguang Song, Yangping Liu,* Copper-Catalyzed Trifluoromethylation of Ynones Coupled with Dearomatizing Spirocyclization of Indoles: Access to CF 3-Containing Spiro[cyclopentane-1,3'-indole], Org. Lett. 2020, 22(8), 3291-3296. (IF 6.542)
6. Xing Wang#, Chao Peng#, Ke He, Kaiyun Ji, Xiaoli Tan, Guifang Han*, Yanxia Liu*, YangpingLiu, Yuguang Song*, Intracellular Delivery of Liposome-encapsulated Finland Trityl Radical for EPR Oximetry, Analyst, 2020, DOI: 10.1039/D0AN00108B
7. Xue Wang, Kaiyun Ji, Antal Rockenbauer, Yangping Liu and Yuguang Song*, Host–guest interaction of nitroxide radicals with water-soluble pillar[6]arenes, Org. Biomol. Chem., 2020, 18, 2321–2325.
8. Xiaoli Tan, Kaiyun Ji, Xing Wang, Ru Yao, Guifang Han, Frederick A. Villamena,Jay L. Zweier, Yuguang Song*, Antal Rockenbauer*, Yangping Liu,* Discriminative Detection of Biothiols through Thiol-Trapping Technique using Methanethiosulfonate Trityl Probe and Electron Paramagnetic Resonance Spectroscopy, Angew. Chem. Int. Ed.,2020, 59, 928-934.
9. Yuying Qu, Yingchun Li, Xiaoli Tan, Weixiang Zhai, Guifang Han, Jingli Hou, Guoquan Liu, Yuguang Song,* and Yangping Liu,* Synthesis and Characterization of Hydrophilic Trityl Radical TFO for Biomedical and Biophysical Applications, Chem. Eur. J.2019,25(33), 7888-7895.
10. Guifang Han,+ Li Xue,+ Lili Zhao, Tiaozhen Zhu, Jingli Hou, Yuguang Song,* and Yangping Liu,* Access to CF3-Containing Cyclopentaquinolinone Derivatives from Indolyl-ynones via Silver-Catalyzed One-pot Reaction, Adv. Synth. Catal.2019, 361, 678-682. (VIP paper)
11. Jingli Hou,Haiyan He,Saipeng Huang,Meng Qian,Jie Wang,Xiaoli Tan, Guifang Han,Yuguang Song,*Zhelong Xu*and YangpingLiu*，A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury, Chem. Commun.2019, 55, 1205-1208.(InsideFront Cover)
12. Weixiang Zhai, Yalan Feng, Huiqiang Liu, Antal Rockenbauer*, Deni Mance, Shaoyong Li, Yuguang Song*, Marc Baldus, Yangping Liu*, Diastereoisomers of L-Proline-linked TAM-nitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions，Chem. Sci. 2018, 9, 4381-4391. (OutsideFront Cover)
13. Xiaoli Tan, Shanqing Tao, Wenbo Liu, Antal Rockenbauer,Frederick A. Villamena,Jay L. Zweier,Yuguang Song*, and Yangping Liu*, Synthesis and Characterization of Perthiatriarylmethyl Radical and Its Dendritic Derivatives with High Sensitivity and Selectivity to Superoxide Radical, Chem. Eur. J. 2018, 24, 6958-6967.(OutsideFront Cover)
14. Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song*, Yangping Liu*, A Near-Infrared Ratiometric/Turn-on Fluorescent Probe for In Vivo Imaging of Hydrogen Peroxide in a Murine Model of Acute Inflammation，Anal. Chim. Acta 2018, 1024, 169-176.
15. Xiaoli Tan, Li Chen, Yuguang Song*, Antal Rockenbauer, Frederick A. Villamena, Jay L. Zweier, and Yangping Liu*,Thiol-dependent reduction of the triester and triamide derivatives of Finland trityl radical triggers O2-dependent superoxide production, Chem. Res. Toxicol. 2017, 30 (9), 1664–1672.
16. Pengjiao An，Nannan Yu，Ruisheng Sun，Xiaofang Sui*, Yuguang Song*, Characterization of the interaction between an esterified TAM radical with bovine serum albumin, Chem. J. Chinese Universities，2017, 38(8):1354-1361.
17. Xiaoli Tan, Yuguang Song,* Huiqiang Liu,a Qinwen Zhong,* Antal Rockenbauer, Frederick A. Villamena, Jay L. Zweier and Yangping Liu,* Supramolecular host–guest interaction of tritylnitroxide biradicals with cyclodextrins: modulation of spin–spin interaction and redox sensitivity, Org. Biomol. Chem., 2016, 14(5): 694-1701 （IF=3.562）
18. Yuguang Song, Yangping Liu, Wenbo Liu, Frederick A. Villamena, and Jay L. Zweier, Characterization of the binding of the Finland trityl radical with bovine serum albumin, RSC Adv., 2014, 4, 47649-47656
19. Yuguang Song, Yangping Liu, Craig Hemann, Frederick A. Villamena, and Jay L. Zweier, Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity, J. Org. Chem., 2013, 78 (4): 1371-1376.
20. Yangping Liu1, Yuguang Song1, Francesco De Pascali, Xiaoping Liu, Frederick A.Villamena, Jay L. Zweier, Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe, Free Radical Biol. Med., 2012, 53: 2081-2091.
21. Yu-guang Song, Bin Liu, Yangping Liu, Frederick A.Villamena and Yang Liu, Biphasic regulation of Superoxide radical levels in Mn-depleted and photoactivated PSII, Photosynthetica, 2011, 49 (3): 353-360.
22. Yangping Liu1, Yuguang Song1, Li-bo Du, Frederick A. Villamena, Yiqiong Ji, Qiu Tian, Ke-Jian Liu, and Yang Liu, Novel Glutathione-linked Nitrones as Dual Free Radical Probes, New J. Chem., 2011, 35: 1485-1490.
Grants
1. Natural Science Foundation of China,Development of stable radical-based spin traps for nitric oxide (NO)and their application for monitoring the release of NO donors inmyocardial ischemia-reperfusion model. 01/2020—12/2023, PI
2. Natural Science Foundation of China,Molecular design, synthesis and properties of trityl-based superoxidespin traps. 01/2016—12/2018, PI
3. Natural Science Foundation of Tianjin, Development of EPR/fluorescent dual-mode superoxide probe. 04/2015—03/2018, PI
4. Natural Science Foundation of China,Design, synthesis and high-field DNP properties of heterogeneous biradicals with tunable exchange interactions and relaxation times. 01/2019—12/2022, CO-PI
5. Natural Science Foundation of China, Novel biradicals as highly sensitive and selective redox probes. 01/2016—12/2019, CO-PI
