​Huining He,Professor
发布人：药学院-英文  发布时间：2019-12-05   浏览次数:226

Huining He, Ph.D.


 

Huining He, PhD

Professor

Department of Pharmaceutical Sciences

Tianjin Medical University

22 Qixiangtai Road

Tianjin 30000780

Phone: +86-22-83336658

Email: hehuining@tmu.edu.cn

 

Research Interest

Design and Applications of Drug Delivery Systems for Macromolecular Therapeutics

 

Education

B.S.     Tianjin University, Tianjin, China, 2005

Joint Ph.D.   University of Michigan, Ann Arbor, USA, 2009

Ph.D.  Tianjin University, Tianjin, China, 2010

Postdoctoral Fellow   University of Michigan, Ann Arbor, USA, 2011

Postdoctoral Fellow   Max Planck Institute of Biophysics, Frankfurt, German, 2012

Postdoctoral Fellow   Tianjin University, Tianjin, China, 2013

 

Professional Experience

2018-present   Professor, Department of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China

2013-2017      Associate Professor, Department of Pharmaceutical Sciences, Tianjin Medical University, Tianjin

 

Honors

  1. 2019 Tianjin Science & Technology Nova Program

  2. 2018 Tianjin Special Talents Recommendation Program Young Top Talent

  3. 2018 First Level Candidates of 131 Innovative Talents Training Project

  4. 2017 Young Elite Scientists Sponsorship Program by Tianjin

  5. 2017 Tianjin Innovative Talent Promotion Program

  6. 2014 Second Level Candidates of 131 Innovative Talents Training Project

  7. 2013Third Level Candidates of 131 Innovative Talents Training Project

  8. 2012 International Training Program for Excellent Postdoctors in Tianjin

 

Professional Service

Membership of Academic Society

The Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN)

Tianjin Society of Biomedical Engineering

Chinese Pharmaceutical Association

Chinese Society of Biomedical Engineering

Tianjin Medical Imaging Technology Research Association

Tianjin Pharmaceutical Association

Tianjin Association of Young Scientific Workers

Asian Journal of Pharmaceutical Sciences

 

Invited lectures

  1. Regenomics and Therapeutics Delivery in Conjunction with A3 Foresight Meeting, Ewha Womans University, February 27, 2014, Seoul, Korea

  2. 2nd A3 Foresight International Symposium on Nano-Biomaterials and Delivery Strategies in Regenerative Medicine for Intractable Diseases, October8,2014, Tokyo, Japan

  3. A3 Foresight International Symposium on Nanotherapeutics and Regenomics, September 16,2015, Seoul, Korea

  4. International Forum on Leading Edge Technologies on Crystallization Engineering and Pharmaceutics Development, October 15, 2016, Tianjin, China

  5. The 11th Chinese Pharmaceutical Conference 2017, October 29, 2017, Shanghai, China

  6. The 12th Chinese Pharmaceutical Conference 2018, December 1, 2018, Guangzhou, China

  7. The 13th Chinese Pharmaceutical Conference 2019, October 13, 2019, Yantai, China

     

Publication

  1. Xing Pei1, Jiyoung Shin1, Heejung Kim1, Nana Wang, Miyun Yoon, Xiongwen Chen, Jianqing Gao, Huining He*, Seungjin Lee*. Cardiac-derived stem cell engineered with constitutively active HIF-1α gene enhancesblood perfusion of hindlimb ischemia. Journal of Industrial and Engineering Chemistry. 2021. Epub ahead of print. doi.org/10.1016/j.jiec.2021.09.020.

  2. Xing Pei, Xiaojuan Zhang, Lu Zhang, Mengmeng Yuan, Lu Sun, Fei Yu, Bangmao Wang, Jingwen Zhao* , Huining He* ,Victor C. Yang. Targeted exosomes for co-delivery of siFGL1 and siTGF-β1trigger combined cancer immunotherapy by remodeling immunosuppressive tumormicroenvironment.Chemical Engineering Journal, 421:129774, 2021.

  3. Zhili Yu1, Xiaojuan Zhang1, Xing Pei1, Weiran Cao, Junxiao Ye, Jianxin Wang ,Lu Sun, Fei Yu, Jiancheng Wang, Nan Li, Kyuri Lee, Stefan Barth, Victor C.Yang, Huining He*. Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA. International Journal of Pharmaceutics, 606(1):120940, 2021.

  4. Sunhui Chen, Qiujun Qiu , Dongdong Wang, Dejun She , Bo Yin, Meihong Chai, Huining He*, Dong Nyoung Heo, Jianxin Wang*. Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection. Frontiers of Chemical Science and Engineering, 1-10, 2021.

  5. You Xu1 , Xiaojuan Zhang1 , Nana Wang, Xing Pei, Yiyue Guo, Jianxin Wang, Stefan Barth, Fei Yu, Seung Jin Lee, Huining He*, Victor C. Yang. Cell Penetrating Peptide Enhanced Insulin Buccal Absorption. International Journal of Pharmaceutics, 584:119469, 2020.

  6. Xing Pei1 , Heejung Kim1 , Minjoo Lee, Nana Wang, Jiyoung Shin, Seungjin Lee*, Miyun Yoon, Victor C. Yang, Huining He*. Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model. Journal of Controlled Release, 322:610–621, 2020.

  7. Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He*, Lu Sun*. MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging. Biomaterials Science, 8(8):2308, 2020.

  8. Hui Cui, Bowen Zhang, Haolin Ding, Youming Hu, Xianhua Wang, Liang Xu, Xiaojie Jiao, Huining He*, Xu Wang*, Xianshun Zeng, Victor C. Yang. A cis-diol/pH Dual-Responsive Upconversion Nanoplatform: Synthesis, Characterization, and in vitro Demonstration. Journal of Biomedical Nanotechnology, 2019.

  9. Ergang Liu, Meng Zhang, Junbo Gong, Yongzhuo Huang, Yanna Cui, Lu Sun, Weibing Dong, Huining He* and Victor C. Yang*.Tat functionalized Ag-Fe3O4 nano-composites as tissue-penetrating vehicles for tumour magnetic targeting and drug delivery. Acta Pharmaceutica SinicaB,000(006):956-968,2018.

  10. Lu Sun, Shuping Xie, Xiuru Ji, Jingming Zhang, Dongmei Wang, Seung Jin Lee, Hyukjin Lee,* Huining He* and Victor C. Yang. MMP-2 responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging. Biomedical Science,6: 2619-2626, 2018.

  11. Junxiao Ye1, Xing Pei1, Hui Cui, Zhili Yu, Hyukjin Lee, Jianxin Wang, Xu Wang, Lu Sun*, Huining He*, Victor C. Yang. Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate. Journal of Industrial and Engineering Chemistry, 63: 103-111, 2018.

  12. Lu Sun, Shuping Xie, Jing Qi, Ergang Liu,  Di Liu, Quan Liu,  Sunhui Chen, Huining He*, Victor C  Yang*. Cell-Permeable, MMP-2 Activatable, Nickel Ferrite and His-tagged Fusion Protein Self-Assembled Fluorescent Nanoprobe for Tumor Magnetic Targeting and Imaging. ACS Applied Materials & Interfaces, 9(45):39209-39222, 2017.

  13. Zhili Yu1, Junxiao Ye1, Xing Pei, Lu Sun, Ergang Liu, Jianxin Wang, Yongzhuo Huang, Seung Jin Lee, Huining He*. Improved Method for Synthesis of Low Molecular Weight Protamine-siRNA Conjugate. Acta Pharmaceutica Sinica B. 8(1):116–12, 2018.

  14. Junxiao Ye, Ergang Liu, Junbo Gong, Jianxin Wang, Yongzhuo Huang, Huining He* and Victor C. Yang*. High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA. Theranostics, 7(9):2495-2508, 2017. 

  15. Sunhui Chen1, Qiuling Liang1, Ergang Liu1, Zhili Yu, Lu Sun, Junxiao Ye, Meong-Cheol Shin, Jianxin Wang, and Huining He*. Curcumin/sunitinib co-loaded BSA-stabilized SPIOs for synergistic combination therapy for breast cancer. Journal of Material Chemistry B, 5:4060-4072, 2017.

  16. L Pang, Chun Zhang, Jing Qin, Limei Han, Ruixiang Li, Chao Hong, Huining He* and Jianxin Wang*. A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles. Drug Delivery. 24(1):83-91, 2017.  

  17. Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung-Jin Lee, Junbo Gong*, Huining He* and Victor C. Yang*. Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer. Frontiers of Chemical Science and Engineering, 1-6, 2017. 

    Huining He1, Lu Sun1, Junxiao Ye, Ergang Liu, Sunhui Chen, Qiuling Liang, Meong Cheol Shin, Victor C Yang*. Enzyme-Triggered, Cell Penetrating Peptide-Mediated Delivery of Anti-Tumor Agents. Journal of Controlled Release,240: 67–76, 2016.

  18. Jianyong Sheng1, Huining He1, Limei Han, Jing Qin, Sunhui Chen, Ge Ru, Ruixiang Li, Pei Yang, Jianxin Wang,* and Victor C. Yang*. Enhancing Insulin Oral Absorption by Using Mucoadhesive Nanoparticles Loaded with LMWP-linked Insulin Conjugates. Journal of Controlled Release, 233: 181–190, 2016.

    Junxiao Ye1, Ergang Liu1, Zhili Yu, Xing Pei, Sunhui Chen, Pengwei Zhang, Meong-Cheol Shin, Junbo Gong, Huining He* and Victor C. Yang*. CPP-Assisted Intracellular Drug Delivery, What Is Next？International Journal of Molecular Sciences,17(11): 1892, 2016. 

  19. Sunhui Chen1, Qiuling Liang1, Shuping Xie, Ergang Liu, Zhili Yu, Lu Sun, MeongCheol Shin, Seung Jin Lee, Huining He*, Victor C Yang*. Curcumin Based Combination Therapy for Anti-breast Cancer: From in vitro Drug Screening to in vivo Efficacy Evaluation. Frontiers of Chemical Science and Engineering, 1-6, 2016.  

    Junxiao Ye1, MeongCheol Shin1, Qiuling Liang, Huining He*, and Victor C. Yang*.15 years of ATTEMPTS: A macromolecular drug delivery system based on the CPP-mediated intracellular drugdelivery and antibody targeting. Journal of Controlled Release, 205: 58–69, 2015. 

  20. Huining He1, Junxiao Ye1, Ergang Liu, Qiuling Liang, Quan Liu, and Victor C. Yang*. Low Molecular Weight Protamine (LMWP): A Nontoxic Protamine Substitute and an Effective Cell-Penetrating Peptide. Journal of Controlled Release, 193: 63–73, 2014.

  21. Ergang Liu, Jianyong Sheng, Junxiao Ye, Junbo Gong, Victor C. Yang, Jianxin Wang*, Huining He*. CPP Mediated Insulin Delivery: Current Status and Promising Future. Current Pharmaceutical Biotechnology, 15(3): 240-255, 2014.   

  22. Huining He1, Junxiao Ye1, Yinsong Wang, Quan Liu, Hee Sun Chung, Young Min Kwon, Meong Cheol Shin, Kyuri Lee, and Victor C. Yang*. Cell-Penetrating Peptides Meditated Encapsulation of Protein Therapeutics into Intact Red Blood Cells and its Application. Journal of Controlled Release, 176: 123-132, 2014.

  23. Huining He, Jianyong Sheng, Allan E. David, Youngmin Kwon, Jian Zhang, Yongzhuo Huang, Jianxin Wang*, and Victor C. Yang*. The Use of Low Molecular Weight Protamine Chemical Chimera to Enhance Monomeric Insulin Intestinal Absorption. Biomaterials, 34(31): 7733-7743, 2013.

  24. Huining He, Allan David, Beata Chertok, Adam Cole, and Victor Yang*. Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System. Pharmaceutical Research, 2013, 30(10): 2445-58.

  25. Huining He, Junxiao Ye, Jingkang Wang, and Victor C. Yang*. Significance and strategies in developing delivery systems for bio-macromolecular drugs. Frontiers of Chemical Engineering in China, 7(4):496-507, 2013.

  26. Huining He, Junxiao Ye, Jianyong Sheng, Jianxin Wang, Yongzhuo Huang, Guanyi Chen, Jingkang Wang, and Victor C. Yang*. Overcoming Oral Insulin Delivery Barriers: Application of Cell Penetrating Peptide and Silica-Based Nanoporous Composites. Frontiers of Chemical Engineering in China, 7(1):9-19, 2013.

  27. Junxiao Ye, Huining He*, Junbo Gong, Weibing Dong, Yongzhuo Huang, Jianxin Wang, Guanyi Chen, and Victor C. Yang*. Ultrasound-Mediated Targeted Microbubbles: A New Vehicle for Cancer Therapy. Frontiers of Chemical Engineering in China,7(1): 20-28, 2013.

  28. Huining He, Allan E. David, Jian Zhang, Yoon Shin Park, Jianxin Wang, Yongzhuo Huang, Jingkang Wang, and Victor C. Yang*. LMWP/Insulin Formulation in Attenuating Protamine-Masqueraded Insulin Allergy in Diabetic Patients. Macromolecular Research, 19:  1224-1226, 2011.

  29. Huining He, Weibing Dong, Junbo Gong, Jingkang Wang*, and Victor C, Yang*. Developing macromolecular therapeutics: the future drug of choice. Frontiers of Chemical Engineering in China, 4: 10-17, 2010.

     

    Listed above are publications as first author or corresponding author; listed below are publications as co-author.

     

  30. Ruixiang Li, Zhiqing Pang, Huining He, Seungjin Lee, Jing Qina, Jian Wu, Liang Pang, Jianxin Wang*, Victor C. Yang*. Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation. Journal of Controlled Release, 261: 234-245, 2017.

  31. Meong Cheol Shin, Kyoung Ah Min, Heesun Cheong, Cheol Moon, Yongzhuo Huang, Huining He, Victor C. Yang*. Tandem-Multimeric F3-Gelonin Fusion Toxins for Enhanced Anti-Cancer Activity for Prostate Cancer Treatment. International Journal of Pharmaceutis, 524(1-2):101-110, 2017, 2017.

  32. Kyoung Ah Min，Huining He, Victor C. Yang，Meong Cheol Shin*. Construction and characterization of gelonin and saporin plasmids for toxic gene-based cancer therapy. Archives of Pharmacal Research, 39(5):677-686, 2016.

  33. Tingting Lin, Pengfei Zhao, Yifan Jiang, Yisi Tang, Hongyue Jin, Zhenzhen Pan, Huining He, Victor C. Yang, and Yongzhuo Huang*. Blood−Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS Nano,10 (11), 9999–10012, 2016. Meong Cheol Shin, Kyoung Ah Min, Heesun Cheong, Cheol Moon, Yongzhuo Huang, Huining He, Victor C. Yang*.

  34. Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity. Pharmaceutical Research, 33(9): 2218–2228, 2016.

  35. Lichao Sun1, Joseph Burnett1, Mari Gasparyan, Fangying Xu, Hui Jiang, Chang-Ching Lin, Ila Myers, Hasan Korkaya, Yajing Liu, Jamie Connarn, Huining He, Ning Zhang, Max S. Wicha, Duxin Sun* Novel Cancer Stem Cell Targets during Epithelial to Mesenchymal Transition in PTEN-deficient Trastuzumab-resistant Breast Cancer. Oncotarget, 7(32): 51408-51422,2016.

  36. Tingting Lin, Ergang Liu, Huining He, Meong Cheol Shin, Cheol Moon, Victor C. Yang*, Yongzhuo Huang*. Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides. Acta Pharmaceutica Sinica B. 6(4):352–358, 2016.

  37. Yaping Wang, Tingting Lin, Wenyuan Zhang, Yifan Jiang, Hongyue Jin, Huining He, Victor C. Yang, Yi Chen, Yongzhuo Huang*. A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging. Theranostics, 5(8):787-795, 2015.

  38. Meong Cheol Shin, Jingwen Zhao, Jian Zhang, Yongzhuo Huang, Huining He, Mei Wang, Kyoung Ah Min, Victor C. Yang*. Recombinant TAT–Gelonin Fusion Toxin: Synthesis and Characterization of Heparin/Protamine-Regulated Cell Transduction. Journal of Biomedical Materials Research: Part A, 103(1):409-419, 2015.

  39. Meong-Cheol Shin, Jian Zhang, Kyoung Ah Min, Huining He, Allan E. David, Yongzhuo Huang, Victor C. Yang*. PTD-Modified ATTEMPTS for Enhanced Toxin-based Cancer Therapy: An In Vivo Proof-of-Concept Study. Pharmaceutical Research, 32 (8):2690–2703, 2015.

  40. Yaping Wang, Yifan Jiang, Meng Zhang, Jiao Tan, Jianming Liang, Huixin Wang, Yaping Li, Huining He,Victor C. Yang*, and Yongzhuo Huang*. Protease-Activatable Hybrid Nanoprobe for Tumor Imaging. Advanced Functional Materials, 24: 5443-5453, 2014.

  41. Huixin Wang, Yongxing Zhao, Huiyuan Wang, Junbo Gong, Huining He, Meong Cheol Shin, Victor C. Yang*, Yongzhuo Huang*.LMWP-modified PLGA Nanoparticles for Overcoming Drug-resistant Cancer in Achieving Synergistic Multipronged Delivery. Journal of Controlled Release, 192: 47-56, 2014.

  42. Meong Cheol Shin, Jian Zhang, Kyoung Ah Min, Kyuri Lee, Youngro Byun, Allan E. David, Huining He, Victor C. Yang*. Cell-penetrating peptides: Achievements and Challenges in Application for Cancer Treatment. Journal of Biomedical Materials Research: Part A, 102(2): 575-587, 2014.

  43. Yongzhuo Huang*, Yifan Jiang, Huiyuan Wang, Jianxin Wang, Meong Cheol Shin, Youngro Byun, Huining He, Yanqin Liang, and Victor C. Yang*. Curb Challenges of the “Trojan Horse” Approach: Smart Strategies in Achieving Effective Yet Safe Cell-Penetrating Peptide Based Drug Delivery. Advanced Drug Delivery Reviews,65(10): 1299-1315, 2013.

  44. JianZhang, MeongCheol Shin, Allan E David, Jie Zhou, Kyuri Lee, Huining He, Victor C. Yang. Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform. Molecular Pharmaceutics, 10(10):3892-902, 2013.

  45. Yoon Shin Park, Allan E. David, Younzhuo Huang, Jun-Beom Park, Huining He, Youngro Byun, and Victor C. Yang*.  In vivo delivery of cell-permeable antisense hypoxia-inducible factor 1α oligonucleotide to adipose tissue reduces adiposity in obese mice. Journal of Controlled Release, 161:1-9, 2012.

  46. Runyan Li, Weibing Dong,Huining He, Hao Yan, Xiaobin Jiang, and Junbo Gong*. Isolation, characterization and phase transformation of new ginsenoside compound k hydrate and methanol solvates. Crystal Research and Technology, 47: 377-384, 2012.

  47. Yoon Shin Park, Younzhuo Huang, Yoon Jeong Park, Allan E. David, Lindsay White, Huining He, Hee Sun Chung, and Victor C. Yang*. Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1 α -oligonucleotide. Journal of Controlled Release, 144:82-90, 2010.

  48. Weibing Dong, Huining He, Junbo Gong, and Victor C, Yang*. Immobilization of penicillin G acylase onto amino-modified silica hydrogel. Frontiers of Chemical Engineering in China, 4:87-90, 2010.

                    

Grant

Ongoing:

  1. 2022.01-2025.12, National Natural Science Foundation of China,8217131811, (PI, ¥530,000)

    “Study on multifunctional exosome-thermosensitive gel in situ drug delivery system for inhibiting post-surgical glioma recurrence”

  2. 2021.07- 2023.06, National Key Research and Development Plan,  2021YFE0106900 , (PI, ¥1400,000)

    “Targeted delivery of siRNAs using SNAP tag based antibody format for precision immunotherapy of

    specific subsets of Leukemia”

  3. 2020.11-2023.10, The Beijing-Tianjin-Hebei Basic Research Cooperation Project,20J00216 , (PI, ¥600,000)

    “The combinaton effects of chemotherapy and immunotherapy on esophageal cancer by precision drug delivery system”

Completed:

  1. 2016.12-2019.11, National Key Research and Development Plan, 2016YFE0119200, (PI, ¥960,000)“Research on development of key biotherapeutics delivery strategies and cardiac stem cell tissue engineering for regenerative treatment of Limb Ischemia”

  2. 2015.01-2017.12, National Natural Science Foundation of China, 81402856, (PI, ¥230,000)“Research on tomor-targeted and site-specific activated prodrug type macromolecular drug delivery system for colon cancer therapy”

  3. 2015.04-2018.03, Tianjin Research Program of Application Foundation and Advanced Technology,15JCYBJC28700, (PI, ¥100,000) “Research on key technologies on gene therapy of colon cancer using enzyme sensitive and targeting systems”

  4. 2015.04-2018.03 Tianjin Research Program of Application Foundation and Advanced Technology, 15JCQNJC13600, (¥60,000)“A cell based screening assay system of peptide substrate for tumor associated protease”

  5. 2014.10-2016.09 The Open Project Program of Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, CTD2014-02,(PI, ¥30,000)“Research on Multifunctional Oral Delivery System for Insulin”

  6. 2013.10-2015.09 The Open Project Program of Key Lab of Smart Drug Delivery of Ministry of Education(Fudan University), SDD2013-04, (PI, ¥50,000)“Development of Oral Insulin Delivery System Based on Cell Penetrating Peptides”

  7. 2013.08-2018.07, National Natural Science Foundation of China A3 Foresight Program, 81361140344, (¥4,000,000)“Nano-Biomaterials and Delivery Strategies in Regenerative Medicine for Intractable Diseases”

  8. 2012.10-2015.09 Tianjin Research Program of Application Foundation and Advanced Technology Key Project, 12JCZDJC34000, (¥200,000)“Construction and Application of Antibody Magnetic Nanoparticles for in vitro Removing of Blood Cancer Cells”