Yinsong Wang, M.D.
Yinsong Wang, MD
Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-22-83336658
Email: wangyinsong@tmu.edu.cn
Education
B.S. Shenyang Pharmaceutical University, Shenyang, China, 1997
M.S. Ocean University of China, Qingdao, China, 2003
M.D. Chinese Academy of Medical Sciences & Pecking Union Medical College, Beijing, China, 2006
Postdoctoral Fellow Tianjin Medical University, Tianjin, China, 2012
Professional Experience
1997--2000 Assistant Engineer, Qingdao Haier Biological PharmaceuticalCo.,LTD, Qingdao, China
2006--2010 Instructor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2011--2015 Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2015-- Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
Honors
1. 14th Five Year and TMU talent project
2. Tianjin Young and Middle-Aged Backbone Innovative Talent Support Program
3. 13th Five Year and TMU talent project
4. TianjinScience and Technology Award (2nd class) in 2013
5. 11th Five New Century Talents of Tianjin Medical University
Professional Service
Reviewer for:
Advanced Materials
Advanced Functional Materials
Science Advances
Biomaterials
ACS Applied Materials & Interfaces
Journal of Controlled Release
Cancer Letter
Theranostics
International Journal of Nanomedicine
Nanotechnology
Carbohydrate Polymers
Drug Delivery
Polymer Chemistry
RSC Advances
Journal of Microencapsulation
Membership of Academic Society
Nano Oncology Professional Committee of Chinese Anticancer Association
Chinese Society for Biomaterials (CSBM)
The Youth Work Committee of Tianjin Pharmaceutical Association
Publication
1. Zhang T#, Liu H#, Li L#, Guo Z, Song J, Yang X,Wan G, Li R*, Wang Yinsong*. Leukocyte/platelet hybrid membrane-camouflaged dendritic large poremesoporous silica nanoparticles co-loaded with photo/chemotherapeuticagents for triple negative breast cancer combination treatment. Bioact Mater, 2021, 6: 3865-3878. IF: 14.593
2. Li Z#, Pan W#, Shi E#, Bai L, Liu H, Li C, Wang Yinsong*, Jiayin Deng*,Wang Y*. A multifunctional nanosystem based on bacterial cell-penetrating photosensitizer for fighting periodontitis via combining photodynamic and antibiotic therapies. ACS Biomater Sci Eng, 2021, 7: 772-786. IF: 4.749
3. Cheng Z#, Cheng Y#, Chen Q, Li M, Wang J, Liu H,Li M, Ning Y, Yu Zh∗, Wang Yinsong∗, Hao Wangc∗. Self-assembly of pentapeptides into morphology-adaptablenanomedicines for enhanced combinatorial chemo-photodynamictherapy. Nano Today, 2020, 33: 100878. IF: 20.722
4. Cheng Y#, Chen Q#, Guo Z, Li M, Yang X, Wan G,*Chen H, Zhang Q, Wang Yinsong*. An intelligent biomimetic nanoplatform for holistic treatment of metastatic triple-negative breast cancer via photothermal ablation and immune remodeling. ACS Nano, 2020, 14: 15161-15181. IF: 15.881
5. Shi S, Wang Y, Wang B, Chen Q, Wan G, Zhang J, Zhang L, Li C*, Yinsong Wang*. Homologous-targeting biomimetic nanoparticles for photothermal therapyand Nrf2-siRNA amplified photodynamic therapy against oral tonguesquamous cell carcinoma. Chem Eng J, 2020, 388: 124268. IF, 13.273
6. Wan G#, Cheng Y#, Song J, Chen Q, Chen B, Liu Y,Ji S, Chen H*, Wang Yinsong*.Nucleus-targeting near-infrared nanoparticles based on TAT peptideconjugatedIR780 for photo-chemotherapy of breast cancer. Chem Eng J, 2020, 380: 122458. IF, 13.273
7. ZhangT#, LiuH#, LiY, Li C*, WanG, ChenB, LiC, Wang Yinsong*. A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition. Acta Biomater, 2019, 99: 412-425. IF: 8.947
8. Gao C, Zhang Y, Zhang Y, Li S, Yang X, Chen Y, Fu J, Wang Yinsong*, Yang X*. cRGD-modified and disulfide bond-crosslinkedpolymer nanoparticles based on iopamidol as atumor-targeted CT contrast agent. Polym Chem, 2020, 11: 889. IF: 5.582
9. Zhang S#, Guo N#, Wan G, Zhang T, Li C, Wang Y, Wang Yinsong*, Liu Y. pH and redox dual‑responsive nanoparticles based on disulfide‑containing poly (β‑amino ester) for combining chemotherapy and COX‑2 inhibitor to overcome drug resistance in breast cancer. J Nanobiotechnol, 2019, 17: 109. IF, 5.345
10. Tian Z, Xu L, Chen Q, Feng R, Lu H, TanH,Kang J, Wang Yinsong*, Hua Yan*. Treatment of surgical brain injury by immune tolerance induced by peripheral intravenous injection of biotargeting nanoparticles loaded with brain antigens. Front Immunol, 2019, 10: 743. IF, 4.816
11. Chen B, Zhang Y, Ran R, Wang B, Qin F, Zhang T,Wan G, Chen H,Wang Yinsong*. Reactive oxygen species-responsive nanoparticles based on a thioketal-containing poly (β-amino ester) for combining photothermal/photodynamic therapy and chemotherapy. Polym Chem, 2019, 10: 4746-4757. IF, 4.760
12. Zhou P#,Qin J#, Zhou C, Wan G, Liu Y, Zhang M, Yang X, Zhang N*, Wang Yinsong*. Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer. Biomaterials, 2019, 195: 86-99. IF, 10.273
13. Wan G#, Chen B#, Li L, Wang D, Shi S, Zhang T, Wang Y, Zhang L, Wang Yinsong*. Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy. Biomaterials, 2018, 155: 25-40. IF, 10.273
14. Shi S#, Zhang L#, Zhu M, Wan G, Li C, Zhang J, Wang Y*, Wang Yinsong*. Reactive oxygen species-responsive nanoparticles based on PEGlated prodrug for targeted treatment of oral tongue squamous cell carcinoma by combining photodynamic therapy and chemotherapy. ACS Appl. Mater. Interfaces 2018, 10, 29260-29272. IF, 8.456
15. Liu Y#, Qiao L, Zhang S, Wan G, Chen B, Zhou P, Zhang N*, Wang Yinsong*. Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy. Acta Biomater, 2018, 66: 310-324. IF, 6.638
16. Zhang S#, Wang Dan, Li Y, Li L, Chen H, Xiong Q, Liu Y*, Wang Yinsong*. pH- and redox-responsive nanoparticles composed of charge-reversible pullulan based shells and disulfide-containing poly(ß-amino ester) cores for co-delivery of a gene and chemotherapeutic agent. Nanotechnology, 2018, 29: 325101. IF, 3.399
17. Liu Y#, Wan G#, Guo H, Liu Y, Zhou P, Wang H, Wang D, Zhang S, Wang Yinsong*, Zhang N*. A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma. Nano Res, 2017; 10(3): 834-855. IF, 7.354
18. Wang Y#, Wan G#, Li Z#, Shi S, Chen B, Li C, Zhang L*, Wang Yinsong*. PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma. Int J Pharm, 2017; 525: 21-31. IF, 3.862
19. Liu X#, Gao C#, Gu J, Gao W, An T, Fu J, Wang Yinsong*, Yang X*. Hyaluronic acid stabilized iodine-containing nanoparticles with Au nanoshell coating for X‑ray CT imaging and photothermal therapy of tumors. ACS Appl Mater Interfaces, 2016; 8: 27622-27631. IF, 7.504
20. Zhang C#, An T#, Wang D, Wan G, Zhang M, Wang H, Zhang S, Li R, Yang X, Wang Yinsong*. Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma. J Control Release, 2016; 226: 193-204. IF, 7.786
21. Wang H#, Wan G#, Liu Y, Chen B, Zhang N*, Wang Yinsong*. Dual-responsive nanoparticles based on oxidized pullulan and a disulfide-containing poly(β-amino) ester for efficient delivery of genes and chemotherapeutic agents targeting hepatoma. Polym Chem, 2016; 7, 6340-6353. IF, 5.375
22. An T#, Zhang C#, Han X, Wan G, Wang D, Yang Z, Wang Y, Zhang L, Y Wang*. Hyaluronic acid-coated poly(b-amino) ester nanoparticles as carrier of doxorubicin for overcoming drug resistance in breast cancer cells. RSC Adv, 2016; 6: 38624-38636. IF, 3.108
23. Wan G#, Liu Y#, Shi S, Chen B, Wang Y, Wang H, Zhang L, Zhang N*, Wang Yinsong*. Hematoporphyrin and doxorubicin co-loaded nanomicelles for the reversal of drug resistance in human breast cancer cells by combining sonodynamic therapy and chemotherapy. RSC Adv, 2016; 6, 100361-100372. IF, 3.108
24. Wang Y#, Liu Y#, Liu Y, Zhou W, Wang H, Wan G, Sun D, Zhang N*, Wang Yinsong*. A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma. Int J Pharm, 2015; 483: 89-100. IF, 3.994
25. Zhou P, An T, Zhao C, Li Y, Li R, Yang R, Wang Yinsong*, Gao X*. Lactosylated PLGA nanoparticles containing e-polylysine for the sustained release and liver-targeted delivery of the negatively charged proteins. Int J Pharm, 2015; 478: 633-643. IF, 3.994
26. Ren Y, Wang R, Liu Y, Guo H, Zhou X, Yuan X, Liu C, Tian J, Yin H, Wang Yinsong*, Zhang N*. A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation. Biomaterials, 2014; 35: 2460-2470. IF, 8.557
27. Liu Y, Wang Y, Zhang C, Zhou P, Liu Y, An T, Sun D, Zhang N*, Wang Yinsong*. Core-shell nanoparticles based on pullulan and poly(β-amino) ester for hepatoma-targeted codelivery of gene and chemotherapy agent. ACS Appl Mater Interfaces, 2014; 6: 18712-18720. IF, 6.723
28. Wang Yinsong*, Liu Y, Liu Y, Wang Y, Wu J, Li R, Yang J, Zhang N*. pH-sensitive pullulan-based nanoparticles for intracellular drug delivery. Polym Chem, 2014, 5: 423-432. IF, 5.520
29. Guo H#, Liu Y#, Wang Y, Wu J, Yang X, Li R, Wang Yinsong*, Zhang N*. pH-sensitive pullulan-based nanoparticle carrier for adriamycin to overcome drug-resistance of cancer cells. Carbohydr Polym, 2014; 111: 908-917. IF, 4.074
30. Wang Yinsong*, Chen H, Liu Y, Wu J, Zhou P, Wang Y, Li R, Yang X, Zhang N*. pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. Biomaterials, 2013; 34: 7181-7190. IF, 8.312
31. Liu Y, Luo Y, Wu J, Wang Yinsong*, Yang X, Yang R, Wang B, Zhang N*. Graphene oxide can induce in vitro and in vivo mutagenesis. Scientific Reports, 2013; 3: e3469. IF, 5.078
32. Wu J, Wang Yinsong*, Yang X, Liu Y, Yang J, Yang R, Zhang N*. Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology, 2012; 23: 355101. IF, 3.842
Grant
Ongoing:
1. National Natural Science Foundation of China (No. 81972903): Multifunctional red blood cells designed based on tumor-targeted oxygen supply and high penetration for treatment of triple-negative breast cancer through combining PTT/PDT and immunotherapy (2020.01--2023.12), project leader.
2. 14th Five-year Talent Project of Tianjin Medical University (2021.01--2025.12), project leader.
3. Infinitus (China). Effect of different formulations of toothpaste on oral diseases (2021.07--2023.07), project leader.
Completed:
1. Project of Young and Middle-aged Key Innovative Talents in Colleges and Universities of Tianjin (2017.09--2020.08), project leader.
2. 13th Five-year Talent Project of Tianjin Medical University (2016.01--2019.12), project leader.
3. Key Project of Natural Science Foundation of Tianjin (18JCZDJC33400): A biomimetic nanocarrier system mediated by mixed membrane from leukocytes and platelets for targeted treatment of triple-negative breast cancer by combining photothermal/photodynamic therapy and immunotherapy (2018.04--2021.03), project leader.
4. National Natural Science Foundation of China (No. 81573005):The design of multi-functional nano-therapeutic system for combination of sonodynamic therapy, chemotherapy and immunotherapy and the study of its targeted anti-hepatoma activities (2016.01--2019.12), project leader.
5. National Natural Science Foundation of China (No. 81371671):A dual-responsive drug delivery nanosystem for carrying and orderly releasing gene/chemotherapeutic drug and its liver-targeting anticancer effects (2014.01--2017.12), project leader.
6. National Basic Research Program of China (the 973 Program, No. 2011CB933100): Early diagnosis of hepatocellular carcinoma based on nanotechnology. (2011.01--2015.12), key member.
7. National Natural Science Foundation of China (No. 30900303):A pH-responsive drug delivery nanosystem for combination treatment on cancer (2010.01--2012.12), project leader.
8. Special China Postdoctoral Science Foundation (No. 201104308): Pullulan-based pH-sensitive drug nanocarrier targeting cell nucleus for reversal of cancer drug resistance. (2012.01-2014.12), project leader.
9. China Postdoctoral Science Foundation (No. 20100480654): pH-sensitive drug nanocarrier based on pullulan for overcoming cancer drug resistance. (2011.10-2013.10), project leader.
