Lu Sun, Ph.D.
Lu Sun, PhD
Associate Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-22-83336658
Email:sunlu@tmu.edu.cn
Education
B.S. Central China Normal University, Wuhan, China, 2003
Ph.D. Nankai University, Tianjin, China, 2009
Postdoctoral Fellow University of California, San Francisco, United States, 2012
Professional Experience
2013.07- 2018.11 Assistant Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
2018.12- present Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
Membership of Academic Society
Chinese Chemical Society
Chinese Society of Biomedical Engineering
Invited lectures
1. Lu Sun, Enzyme Activatable Nanoprobe for Tumor Magnetic Targeting and Imaging, 2nd Bio-Therapeutics Delivery Society Symposium and A3 Foresight International Meetings, Cell-Permeable, June 9,2017, Seoul, Korea
2. Lu Sun, Enzyme-Activatable Cell-Penetrating Peptide Mediated Intracellular Targeting Delivery of Therapeutic Proteins, 2019 International Forum on Innovative Pharmaceutical Research and Development, June 14, 2019, Tianjin, China
Publication
1. Xiaoqiang Tu, Lijun He, Haojie Huang, Haishun Ye, Lu Sun* and Long Yi*, Thiolysis of CBD arylethers for development of highly GSH-selective fluorescent probes. Chemical Communications,2021, 57, 8802-8805.
2. Xing Pei, Xiaojuan Zhang, Lu Zhang, Mengmeng Yuan, Lu Sun, Fei Yu, Bangmao Wang, Jingwen Zhao*, Huining He*, Victor C. Yang, Targeted exosomes for co-delivery of siFGL1 and siTGF-β1 trigger combinedcancer immunotherapy by remodeling immunosuppressivetumor microenvironment. Chemical Engineering Journal, 2021, 421, 129774.
3. Zhili Yu, Xiaojuan Zhang, Xing Pei, Weiran Cao, Junxiao Ye, Jianxin Wang, Lu Sun, Fei Yu, Jiancheng Wang, Nan Li, Kyuri Lee, Stefan Barth, Victor C. Yang, Huining He*, Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA. International Journal of Pharmaceutics, 2021, 606, 120940.
4. Ismail Ismail1, Zhuoyue Chen1, Lu Sun1, Xiuru Ji, Haishun Ye, Xueying Kang, Haojie Huang, Haibin Song, Sarah G. Bolton, Zhen Xi, Michael D. Pluth, Long Yi*, Highly efficient H2S scavengers via thiolysis of positively-charged NBD amines. Chemical Science 2020, 11, 7823-7828.
5. XiuRu Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He*, Lu Sun*, MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging. Biomaterials Science 2020, 8 (8), 2308-2317.
6. Haojie Huang1, XiuRu Ji1, Yaqing Jiang, Changyu Zhang; Xueying Kang, Jiqin Zhu*, Lu Sun*, Long Yi, NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities. Organic & Biomolecular Chemistry 2020, 18 (21), 4004-4008.
7. Ismail Ismail, Zhuoyue Chen, XiuRu Ji, Lu Sun, Long Yi*, Zhen Xi*, A fast-response red shifted fluorescent probe for detection of H2S in living cells. Molecules 2020, 25 (3), 437.
8. Yaqing Jiang, Xiuru Ji, Changyu Zhang, Zhen Xi, Lu Sun*, Long Yi*. Dual-quenching NBD-based fluorescent probes for separate detection of H2S and Cys/Hcy in living cells. Organic & Biomolecular Chemistry, 2019, 17, 8435-8442.
9. Lu Sun, Shuping Xie, Xiuru Ji, Jingming Zhang, Dongmei Wang, Seung Jin Lee, Hyukjin Lee*, Huining He*, Victor C. Yang. MMP-2 responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging. Biomaterials Science, 2018, 6, 2619-2626.
10. Junxiao Ye1, Xing Pei1, Hui Cui, Zhili Yu, Hyukjin Lee, Jianxin Wang, Xu Wang, Lu Sun*, Huining He*, Victor C. Yang. Cellular Uptake Mechanism and Comparative in vitro Cytotoxicity Studies of Monomeric LMWP-siRNA Conjugate. Journal of Industrial and Engineering Chemistry, 2018, 63, 103-111.
11. Lu Sun1, Yaqing Jiang1, Changyu Zhang, Xiuru Ji, Dequn Lv, Zhen Xi*, Long Yi*. A NBD-S-rhodamine dyad for dual-color discriminative imaging of biothiols and Cys/Hcy. New Journal of Chemistry, 2018, 42, 15277-15283.
12. Ergang Liu, Meng Zhang, Hui Cui, Junbo Gong, Yongzhuo Huang, Jianxin Wang, Yanna Cui, Weibing Dong, Lu Sun, Huining He, Victor C.Yang. Tat-functionalized Ag-Fe3O4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery, Acta Pharmaceutica Sinica B. 2018, 8, 956-968.
13. Zhili Yu1, Junxiao Ye1, Xing Pei, Lu Sun, Ergang Liu, Jianxin Wang, Yongzhuo Huang, Seung Jin Lee, Huining He*. Improved Method for Synthesis of Low Molecular Weight Protamine-siRNA Conjugate. Acta Pharmaceutica Sinica B. 2018, 8, 116-126.
14. Guihua Ye, Yajun Jiang, Xiaoying Yang, Hongxiang Hu, Beibei Wang, Lu Sun, Victor C. Yang, Duxin Sun, Wei Gao*.Smart Nanoparticles Undergo Phase Transition for Enhanced Cellular Uptake and Subsequent Intracellular Drug Release in a Tumor Microenvironment. ACS Applied Materials & Interfaces, 2018, 10, 278-289.
15. Lu Sun, Shuping Xie, Jing Qi, Ergang Liu, Di Liu, Quan Liu, Sunhui Chen, Huining He*, Victor C. Yang*. Cell-Permeable, MMP-2 Activatable, Nickel Ferrite and His-Tagged Fusion Protein Self-Assembled Fluorescent Nanoprobe for Tumor Magnetic-Targeting and Imaging. ACS Applied Materials & Interfaces, 2017, 9, 39209-39222.
16. Sunhui Chen1; Qiuling Liang1, Ergang Liu, Zhili Yu, Lu Sun, Junxiao Ye, Meong Cheol Shin, Jianxin Wang, Huining He*. Curcumin/Sunitinib Co-Loaded Bsa-Stabilized Spios for Synergistic Combination Therapy for Breast Cancer. Journal of Materials Chemistry B, 2017, 5, 4060-4072.
17. Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung-Jin Lee, Junbo Gong*, Huining He*, Victor C. Yang*. Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer. Frontiers of Chemical Science and Engineering, 2017, 11, 529-536.
18. Huining He1, Lu Sun1, Junxiao Ye, Ergang Liu, Sunhui Chen, Qiuling Liang, Meong Cheol Shin, Victor C. Yang*. Enzyme-Triggered, Cell Penetrating Peptide-Mediated Delivery of Anti-Tumor Agents. Journal of Controlled Release, 2016, 240, 67-76.
19. Sunhui Chen1, Qiuling Liang1, Shuping Xie, Ergang Liu, Zhili Yu, Lu Sun, Meong Cheol Shin, Seung Jin Lee, Huining He*, Victor C. Yang*, Curcumin Based Combination Therapy for Anti-breast Cancer: From in vitro Drug Screening to in vivo Efficacy Evaluation. Frontiers of Chemical Science and Engineering, 2016, 10, 383-388.
Grant
Ongoing:
1. 2021.07-2023.06, National Key Research and Development Plan, 2021YFE0106900, (¥1400,000)
2. 2020.01-2023.12, National Natural Science Foundation of China, 21977080, (¥660,000)
Completed:
1. 2018.12-2020.11, the Open Project Program of Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), CTD2018-04, (PI, ¥30,000)
2. 2018.01-2021.12, National Natural Science Foundation of China, 81760637, (¥300,000)
3. 2017.04-2020.03, Natural Science Foundation of Tianjin, 17JCYBJC20700, (¥100,000)
4. 2017.01-2019.12, National Natural Science Foundation of China, 81602614, (¥160,000)
5. 2016.12-2019.11, National Key Research and Development Plan, 2016YFE0119200, (¥964,000)
6. 2015.04-2018.03, Tianjin Research Program of Application Foundation and Advanced Technology, 15JCQNJC13600, (PI, ¥60,000)
7. 2015.04-2018.03, Tianjin Research Program of Application Foundation and Advanced Technology,15JCYBJC28700, (¥100,000)
8. 2015.01-2017.12, National Natural Science Foundation of China, 21402143, (PI, ¥250,000)
9. 2015.01-2017.12, National Natural Science Foundation of China, 81402856, (¥230,000)
10. 2015.01-2017.12, National Natural Science Foundation of China, 81402889, (¥230,000)
11. 2014.10-2016.09, the Open Project Program of Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), CTD2014-03, (PI, ¥30,000)
12. 2014.10-2016.09, the Open Project Program of Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), CTD2014-02, (¥30,000)
