Xiaohui Wu, Ph.D.
Xiaohui Wu,PhD
Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-13512945399
Email: xiaohuiwu@tmu.edu.cn
Education
BS Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 1999–2003
Ph.D. Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2005–2010
Ph.D. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, 2007–2010
Professional Experience
2003–2005 Clinical pharmacist, The fourth hospital in wuhan, Wuhan, China
2010–Present The School of Pharmacy of Tianjin Medical University, Lecturer、Professor
2013–2014 Visiting Scholar,The University of Chicago, Chicago, US
Honors
(1) Young and middle-aged backbone innovative talents in universities in Tianjin, 2019
(2) Tianjin Medical University Outstanding teacher Award, 2020.
Reviewer for
Phytother Res, J Ethnopharmacol, Phytomedicine, Bioorganic Chemistry, Front Pharmacol, Comput Biol Med,Bioorganic Chemistry,Fitoterapia, et al.
Membership of Academic Society
Professional Committee of traditional Chinese medicine analysis of the World Federation of traditional Chinese Medicine (Member of a council)
Natural medicine professional committee of China Pharmaceutical Association (Youth Committee)
Professional Committee of Experimental Pharmacology of Tianjin Pharmacological Society (Vice Chairman)
Professional Committee of Network Pharmacology of Tianjin Pharmacological Society (Vice Chairman)
Tianjin science and Technology Commissioner
Publication(First or corresponding author)
(1) Xiao-Hui Wu*, Jun Zhang, Shu-Qing Wang, Victor C. Yang, Samantha Anderson, Yan-Wen Zhang. Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice. Phytomedicine. 21(2014): 1196–1201.
(2)Xiaohui Wu, Jinlan Ruan, V.C. Yang, Zhiyuan Wu, Jianshi Lou, Hongquan Duan, Jun Zhang, Yanwen Zhang, Dean Guo. Three new acetylated benzyl-beta-resorcylate glycosides from Cassia obtusifolia. Fitoterapia.83(2012): 166–169
(3)Xiao-Hui Wu, Jin-Jin Cai, Jin-Lan Ruan, Jian-Shi Lou, Hong-Quan Duan, Jun Zhang, De-An Guo, Zhi-Yuan Wu and Yan-Wen Zhang. Acetylated anthraquinone glycosides from Cassia obtusifolia. J Asian Nat Prod Res. 13(2011): 486–491.
(4) Xiao-HuiWu,Chun-HaoYu,Chun-Feng Zhang, Samantha Anderson and Yan-Wen Zhang. Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout. Am J Chin Med. 42(2014): 257–259.
(5) Xiao-Hui Wu, Chong-Zhi Wang, Jun Zhang, Shu-Qing Wang, Lide Han, Yan-Wen Zhang and Chun-Su Yuan. Effects of Smilaxchinoside A and Smilaxchinoside C, Two Steroidal Glycosides from Smilax riparia, on Hyperuricemia in a Mouse Model. Phytother Res. 2014, 28(12): 1822–1828.
(6) Xiao-Hui Wu*, Jin-LanRuan, Jun Zhang, Shu-QingWang, Yan-WenZhang. Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice. J Ethnopharmacol. 157(2014): 201–205.
(7) Xiao-Hui Wu*,Chong-Zhi Wang, Shu-Qing Wang, Chao Mi, Jun Zhang, Yan-Wen Zhang, Samantha Anderson, Chun-Su Yuan*.Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. J Ethnopharmacol. 162(2015): 362–368.
(8) Pi-Yong Hou, Chao Mi, Yi He, Jun Zhang, Shu-Qing Wang, Fei Yu, Samantha Anderson,Yan-Wen Zhang, Xiao-Hui Wu*. Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. Fitoterapia. 105 (2015) 43–48.
(9) Hong-Gang Li, Pi-Yong Hou, Xi Zhang, Yi He, Jun Zhang, Shu-Qing Wang, Samantha Anderson, Yan-Wen Zhang, Xiao-Hui Wu*. Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT.Fitoterapia. 113 (2016) 1–5.
(10) Ming-Yu Wang, Ming Yang, Pi-Yong Hou, Xiu-Bo Chen, Hong-Gang Li, Jiu-Xing Yan, Jun Zhang, Yan-Wen Zhang, Xiao-Hui Wu*. Intestinal absorption of pallidifloside D are limited by P-glycoprotein in mice.Xenobiotica.2018, 48(7):739–744.
(11) RuiLuo, Xiao-Li Gao, Chang Shi, Yu-Xi Wei, Pi-Yong Hou, Hong-Gang Li, Shu-Qing Wang, Samantha Anderson, Yan-Wen Zhang, Xiao-Hui Wu*. Phytochemical and chemotaxonomic study on the rhizomes of Smilax riparia (Liliaceae).BiochemSyst Ecol.76 (2018): 58–60.
(12) TiantianZuo, YuexinQian, Chunxia Zhang, Yuxi Wei, Xiaoyan Wang,HongdaWang, Ying Hu, Weiwei Li, Xiaohui Wu*, Wenzhi Yang. Data-Dependent Acquisition and Database-DrivenE_cient Peak Annotation forthe ComprehensiveProfiling and Characterization of theMulticomponents from Compound XueshuantongCapsule by UHPLC/IM-QTOF-MS. Molecules. 2019, 24, 3431; doi:10.3390/molecules24193431.
(13) Lijun An, Jun Ma, Xueyuan Yang, Yue Liang, Huimei Wang, Muhetaer Tuerhong, Namrita Lall, Munira Abudukeremu, Yi Zhang, Dongho Lee, Jing Xu, Xiaohui Wu*, Yuanqiang Guo*. Caseahomopene A, a Ring-Expanded HomotriterpenoidFromCaseariaKurzii Showing Anti-Inflammatory Activities in Vitro and in Vivo. Bioorganic Chemistry.98 (2020) 103758.
(14) Dan Wang, Li Tian, Chang Shi, YuXi Wei, Han Wang , TianTian Liu, Ming Gong, YanWen Zhang, RongGuo Yu, XiaoHui Wu*. Network pharmacology-based prediction of the active ingredients and mechanism of ShenGui capsule for application to coronary heart disease. Comput Biol Med. 2020;122:103825. doi: 10.1016/j.compbiomed.2020.103825.
(15) Shunming Zhang, Xiaohui Wu*, Shanshan Bian, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yeqing Gu, Yawen Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu*. Association between consumption frequency of honey and non-alcoholic fatty liver disease: results from a cross-sectional analysis based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study. Br J Nutr.2020 Aug 17;1-9. doi: 10.1017/S0007114520003190. (IF 3.71)
(16)Shunming Zhang, ShubhamKumari, YeqingGu, Xiaohui Wu*, Xiaoyue Li, GeMeng, Qing Zhang, Li Liu, Hongmei Wu, Yawen Wang, Tingjing Zhang, Xuena Wang, Xingqi Cao, Huiping Li, Yunyun Liu, Xiaohe Wang, Shaomei Sun, Xing Wang, Ming Zhou, QiyuJia, Kun Song, Zhong Sun, KaijunNiu*. Soy Food Intake Is Inversely Associated with Newly Diagnosed Nonalcoholic Fatty Liver Disease in the TCLSIH Cohort Study. J Nutr. 2020 Dec 10;150(12):3280-3287.doi: 10.1093/jn/nxaa297. (IF 4.79)
(17)Huiping Li, Yeqing Gu, Xiaohui Wu*, Sabina Rayamajhi, Shanshan Bian, Qing Zhang, Ge Meng, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Amrish Thapa, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Kaijun Niu*. Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: the TCLSIH Cohort Study. Liver Int. 2020 Sep 3. doi: 10.1111/liv.14655. (IF 5.82)
(18)Wang D, Shi C, Ge ZH, Wei YX, Liu TT, Wang Y, Zhou XF, Yang ZJ, Wang WT, Zhang YW, Zhu XH, Zhang J, Li Y, Gong M, Wu XH, Duan HQ.Study of the Mechanism of Action of GuanxinShutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics. Front Pharmacol. 2021 Mar 25;12:650438.doi: 10.3389/fphar.2021.650438. eCollection 2021.
(19)Xuena Wang, Xiaohui Wu, GeMeng, ShanshanBian, Qing Zhang, Li Liu, Hongmei Wu, YeqingGu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xingqi Cao, Huiping Li, Yunyun Liu, Xiaoyue Li, Kun Song, KaijunNiu. Consumption of chilies and sweet peppers is associated with lower risk of sarcopenia in older adults. Aging-US. 2021 Mar 26;13(6):9135-9142.doi: 10.18632/aging.104168.
(20)Yeqing Gu, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Xiaohui Wu, Kaijun Niu. Predictive Value of Thyroid Hormones for Incident Hyperuricemia in Euthyroid Subjects: The Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. EndocrPract. 2021 Apr;27(4):291-297.doi: 10.1016/j.eprac.2020.10.009.
Grant (Principle Investigator)
(1) Research on of anti-hyperuricemic mechanism of saponin glycoside constituents from Smilax riparia based on URAT1 (National Scientific Fund for Chinese Young Scientists, No 81202895 )
(2) Exploration on the integration of network pharmacology effects of saponins from Smilax riparia multi component multi targets based on antihyperuricemia (Chinese postdoctoral fund, No 2013M530882
(3) Research on anti-Prostatic Hyperplasia mechanism of saponin glycoside constituents from Pronephrium penangianum based on multi targets ( Chinese postdoctoral special supported fund. No 2014T70223)
(4) Studies on pharmacodyamic material and mechanism of Smilax riparia for anti-hyperuricemia based on NLRP3/Caspase-1/PDZK1 axis (National Scientific Fund for Chinese Young Scientists, No 81974521)
(5) Study on active components and mechanism of Pronephrium penangianum against benign prostatic hyperplasia (Research start-up fund for returned overseas students of the Ministry of Education)
(6) Studies on the active ingredient and mechanism of total saponins in Smilax riparia synergy with allopurinol of resistance to hyperuricemia (Key projects of Tianjin Natural Science Foundation, No 19JCZDJC33500)
