Meihua Jin, Professor
发布人：药学院-英文  发布时间：2019-12-05   浏览次数:155

 

 Meihua Jin, Ph.D.

 

 


Meihua Jin, Ph.D

Professor

School of Pharmacy

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-13370369063

Email: jinmeihua@

 

Research Interest

Pharmacology of antitumor drugs

Tumor immunotherapy

 

Education

B.S.      Yanbian university, Yanji, China,2003

M.S.     Yeungnam University, Gyeongsan, Korea, 2005

Ph.D     Yeungnam University, Gyeongsan, Korea, 2009

 

Professional Experience

2009.03-2011.02     International Assistant Professor, Yeungnam University, Gyeongsan, Korea

2011.01-2018.12     Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

2019.01-                  Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

 

Honors

2019   Young and Middle-aged Backbone Innovative Talents Training Program for Colleges and Universities in Tianjin

2012      Excellent Young Teachers Program for Colleges and Universities in Tianjin

2012      The second class candidate of Tianjin “131” innovative talent training project

 

Professional Service

 

Membership of Academic Society:

The Division of Industrial Biochemistry and Molecular Biology

Committee of Anti-cancer Agent

Chinese pharmaceutical society

 

Publication

1.         Shunli Pan, Eujin Lee,   Younju Lee, Meihua Jin *, Eunkyung Lee *,   Suppressive effect of tamarixetin, isolated from Inula japonica, on   degranulation and eicosanoid production in bone marrow-derived mast cells,Allergologia et immunopathologia 2021,49(3):42-49.

2.         Xiaoxia Zhao, Ning Zhang,   Yingying Huang, Xiaojing Dou, Xiaolin Peng, Wei Wang, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin *, Dexin Kong   *, Lansoprazole alone or in combination with gefitinib shows   antitumor activity against non-small cell lung cancer A549 cells in vitro and   in vivo,Frontiers in cell and   developmental biology 2021, 9:655559.

3.         Chen Shao, Yingying   Huang, Bingjie Fu, Shunli Pan, Xiaoxia Zhao, Ning Zhang, Wei Wang, Zhe   Zhang, Yuling Qiu, Ran Wang, Meihua Jin *, Dexin   Kong *, Targeting c-Jun in A549 cancer cells exhibits antiangiogenic   activity in vitro and in vivo through exosome/miRNA-494-3p/PTEN signal   pathway,Frontiers in oncology   2021, 11:663183.

4.         Shunli Pan, Xiaoxia Zhao,   Chen Shao, Bingjie Fu, Yingying Huang, Ning Zhang, Xiaojing Dou, Zhe Zhang,   Yuling Qiu, Ran Wang, Meihua Jin*,   Dexin Kong*, STIM1 promotes angiogenesis by reducing exosomal miR-145 in   breast cancer MDA-MB-231 cells,Cell   death & disease 2021, 12(1):38.

5.         Ning Ji, Sungun   Kim, Hyohyun Park, Eujin Lee, Younju Lee, Meihua   Jin*, Eunkyung Lee*, Nepetin, a natural compound from Inulae flos,   suppresses degranulation and eicosanoid generation through PLCγ1 and Akt   signaling pathways in mast cells,Archives   of Pharmacal Research, 2020, 43(2): 224-232.

6.         Shunli Pan, Xiaoxia Zhao,   Ning Ji, Chen Shao, Bingjie Fu, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin*, Dexin Kong*, Inhibitory   effect of taxifolin on mast cell activation and mast cell-mediated allergic   inflammatory response,International   Immunopharmacology, 2019, 71: 205-214.

7.         Chen Shao, Bingjie Fu, Ning   Ji , Shunli Pan, Xiaoxia Zhao, Zhe Zhang, Yuling Qiu, Ran Wang, Meihua Jin*, Ke Wen*, Dexin Kong*,   Alisol B 23-Acetate inhibits IgE/Ag-mediated mast cell activation and   allergic reaction. International   Journal of Molecular Sciences, 2018, 19(12).

8.         Ning Ji, Shunli Pan, Chen   Shao, Yufen Chen, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin*, Dexin Kong*, Spinacetin suppresses the mast cell   activation and passive cutaneous anaphylaxis in mouse model,Frontiers in Pharmacology, 2018, 9:   824.

9.         Xi Chen, Ning Ji, Nan Qin,   Sheng-an Tang, Ran Wang, Yuling Qiu, Hongquan Duan, Dexin Kong, Meihua Jin*,   1,6-O,O-Diacetylbritannilactone inhibits Eotaxin-1 and ALOX15 expression   through inactivation of STAT6 in A549 cells, Inflammation, 2017,   40(6): 1967-1974.

10.      Yufen Chen, Ning Ji, Shunli   Pan, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua   Jin*, Dexin Kong*, Roburic acid suppresses NO and IL-6 production via   targeting NF-kappaB and MAPK pathway in RAW264.7 cells. Inflammation 2017, 40(6):1959-1966.

11.      Meihua Jin*, Sungun Kim, Nan Qin, Xi   Chen, Ning Ji, Sheng-an Tang, Dexin Kong, Eunkyung Lee, Hongquan Duan,   1,6-O,O-Diacetylbritannilactone suppresses activation of mast cell and airway   hyper-responsiveness. Immunopharmacology   and Immunotoxicology, 2017, 39(4):    173-179.

12.      Xiaopeng Wei, Yufen Chen,   Hong Zhu, Xiaoran Wu, Yang Yu, Dexin Kong, Hongquan Duan*, Meihua Jin*, Nan Qin*, Synthesis and   anti-inflammatory activities of 1-O-acetylbritannilactone analogues,Phytochemistry Letters, 2017, 19:   248-253.

13.      Xi Chen, Sheng-an Tang,   Eunkyung Lee, Yuling Qiu, Ran Wang, Hong-Quan Duan, Shingo Dan, Meihua Jin*, Dexin Kong*, IVSE,   isolated from Inula japonica, suppresses LPS-induced NO production via NF-kB and MAPK   inactivation in RAW264.7 cells,Life   sciences,2015,124:8-15.

14.      Xiaoqing Wang, Sheng-An Tang, Ran   Wang, Yuling Qiu, Meihua Jin*, Dexin Kong*,Inhibitory effects of   JEUD-38, a new sesquiterpene lactone from Inula   japonica Thunb, on LPS-induced iNOS expression in RAW264.7 cells,Inflammation,2015,   38(3):941-948.

15.      Meihua Jin,Qianxiang Zhou, Eunkyung Lee, Shingo Dan,   Hongquan Duan, Dexin Kong*, AS252424, a PI3Kg Inhibitor, downregulates inflammatory   responsiveness in mouse bone marrow-derived mast cells,Inflammation,2014,   37(4):1254-1260

16.      Sheng-An Tang, Hong Zhu, Nan Qin, Jingya Zhou, Eunkyung Lee, Dexin Kong, Meihua Jin*, Hongquan Duan*,Anti-inflammatory Terpenes from Flowers of Inula japonica,Planta medica, 2014,80(7):583-589

17.      Meihua Jin, Wennan Zhao,   Yanwen Zhang, Motomasa Kobayashi, Hongquan Duan,* Dexin Kong*,Antiproliferative   effect of aaptamine on human chronic myeloid leukemia K562 cells,International journal of   molecular sciences, 2011,12(11):7352-7359.

18.      Meihua Jin,Kunho Son*,Hyeunwook Chang*, Luteolin-7-O-glucoside suppresses leukotriene   C4production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases   and phospholipase Cg1 inactivated mouse bone marrow-derived   mast cells,Biological & pharmaceutical bulletin,2011, 34(7):1032-1036

19.      Meihua Jin, Yue   Lu, Juhye Yang, Taehyung Jo, Young-in Park, Chongkil Lee, Sangjo Park, Kunho Son*, Hyeunwook Chang*, Anti-inflammatory activity   of 6-Hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of Yam (Dioscorea   batatas) through inhibition of prostaglandin D2 and leukotriene C4 production   in mouse bone marrow-derived mast cells,Archives of   pharmacal research, 2011, 34(9):1495-1501.

20.      Yue Lu,Meihua Jin,Sangjo Park,Kunho Son,Jongkeun Son*, Hyeunwook Chang*,Batatasin I, a naturally occurring   phenanthrene derivative,   isolatedfrom   tuberous roots   of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast   cells,Biological & pharmaceutical bulletin,2011, 34(7): 1021-1025.

21.      Meihua Jin, Seokjong   Suh, Juhye Yang, Yue Lu, Sujeong Kim, Soonyoul Kwon, Taehyung Jo,Jinwan   Kim, Young-in Park, Ghewhan Ahn, Chongkil Lee, Cheorlho Kim, Jongkeun   Son, Kunho Son*, Hyeun wook   Chang*, Anti-inflammatory activity of bark   of Dioscorea batatasDECNE through the inhibition of iNOS and COX-2 expressions in   RAW264.7 cells via NF-kB and ERK1/2 inactivation,Food and chemical toxicology, 2010,48(11): 3073-3079.

22.      Meihua Jin,Eunkyung   Lee,Juhye Yang,Yue Lu,Sanggu Kang,Youngchae Chang, Seungho Lee,Seokjong Suh,Cheorlho Kim,Hyeunwook Chang*, Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1   induced by tumor necrosis factor-ain murine lung epithelial cells. Biological   & pharmaceutical bulletin,2010, 33(1): 1-5.

23.      Meihua Jin, Ju Hye Yang, Eunkyung Lee, Yue Lu,  Soonyoul Kwon, Kunho Son, Jongeeun Son, Hyeun wook Cang*. Antiasthmatic Activity   of Luteolin-7-O- glucoside from Ailanthus altissima through the Down   regulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin   E2 Production in an Ovalbumin-Induced Asthma Model,Biological & pharmaceutical bulletin,2009, 32(9): 1500-1503.

24.      Meihua Jin,   Tae Chul Moon, Zhejiu Quan, Eunkyung Lee, Yunkyung Kim, Juhae Yang,   Seokjong Suh, Taecheon Jeong, Seungho Lee, Cheorlho Kim*, Hyeunwook Chang*, The naturally occurring flavolignan, deoxypodophyllotoxin,   inhibits lipopolysaccharide-induced iNOS expression require inhibition of   NF-κB activation in RAW264.7 macrophage cells,Biological & pharmaceutical bulletin, 2008,   31(7): 1312-1315. (Highlighted paper   selected by Editor-in-chief)

25.      Meihua Jin,   Taechul Moon,Taegyun Hong, Kyongmin Park, Jongkeun Son, Hyeunwook Chang*, 5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)- psoralen Isolated   from Angelica dahurica inhibits Cyclooxygenase-2 and 5-Lipoxygenase in Mouse   Bone Marrow-Derived Mast Cells,Archives of pharmacal research,2008, 31(5): 617-621.

26.      Taechul Moon, Meihua Jin(Co-first   author), Jongkeun Son, and Hyeunwook Chang*, The Effects of   Isoimperatorin Isolated from Angelica dahurica on Cyclooxygenase-2 and   5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells,Archives of pharmacal research,2008, 31(2): 210-215.

27.      Se Jong Kim, Meihua Jin(Co-first   author), Eunkyung Lee, Taechul Moon, Zhejiu Quan, Kunho Son, Kil-ung Kim, Jongkun Son, Hyeunwook Chang*, Effects of Methyl Gallate   on Arachidonic Acid Metabolizing Enzymes: Cyclooxygenase-2 and 5-Lipoxygenase   in Mouse Bone Marrow-Derived Mast Cells. Archives   of pharmacal research,2006, 29 (10): 874-878.

28.      Meihua Jin,Jumin Yook,Eunkyung Lee,Chang Xin Lin,Zhejiu Quan,Kunho Son,Kihwan Bae,Hyun Pyo Kim,Samsik Kang,and Hyeunwook Chang*, Anti-inflammatoryactivity of Ailanthus altissima   in Ovalbumin-Induced Lung Inflammation. Biological   & pharmaceutical bulletin, 2006,29(5): 884-888.

 

Grant

1.      National Natural Science Foundation of China (81672809):The mechanism study of growth inhibition of breast cancer through IgE receptor FcεRI-activated mast cell, (2017.01--2020.12), project leader.

2.      National Natural Science Foundation of China (81202542):Study on the anti-asthmatic multi molecular mechanisms by using lactone probe from Inula japonica and discovery of lead compound, (2013.01--2015.12), project leader.

3.      Natural Science Foundation of Tianjin (13JCYBJC24800): Using ABLOO as a probe to study its anti-asthmatic multi molecular mechanisms and their synergistic effects, (2013.04--2016.03), project leader.

4.      New Teachers’ Fund for Doctor Stations from Ministry of Education, China (20121202120009):The study of anti-asthmatic effects of lactone from Inula japonica, (2013.01--2015.12), project leader.

5.      China Postdoctoral Science Foundation Funded Project (2016M601277): The anti-inflammatory effect and mechanism study of Roburic acid, (2016.11--2018.07), project leader.