Caixia Dong, Ph.D.

Caixia Dong, PhD

Associate Professor

Department of Phytochemistry

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336679

Email: dongcaixia@tmu.edu.cn

Education

B.Sc. ,   Hebei University of Science and Technology, Hebei, China, 2003

M.Sc.,   Shaanxi University of Chinese Medicine,        Shaanxi, China, 2006

Ph.D.,   Toyama University,                                           Toyama, Japan, 2011

Professional Experience

2006-2008  Associate Researcher, Hebei Yiling Pharmaceutical Group

2011-2013  Postdoctoral fellow, School of Chinese Medicine,Hong Kong Baptist University

2013-2020  Assistant Professor, School of Pharmacy, Tianjin Medical University

2020-          Associate Professor, School of Pharmacy, Tianjin Medical University

Research Interest

1. Focus on the active carbohydrates from medicinal plants and their functional evaluation on anti-virus, immunomodulating, anti-tumor and gut flora.

Professional Service

Editorial Board

Pharmacon (ISSN: 1411-4283)

Reviewer for:

Process Biochemistry (ISSN:1359-5113 )

International Journal of Biological Macromolecules (ISSN:0141-8130)

Biomedicine & Pharmacotherapy  (ISSN:0753-3322)

Carbohydrate Polymers (ISSN:0144-8617)

Membership of Academic Society

China Medical Association of Minorities (Medical Resources Branch)

Books

Caixia Dong, Quanbin Han. Ganoderma lucidum (Lingzhi, Ganoderma). Yanze Liu, Zhimin Wang, Junzeng Zhang (Eds), Dietary Chinese Herbs.Springer Vienna, DOI 10.1007/978-3-211-99448-1_85. 2015, pp759-766.

Ten Selected Publications 

1. Yi-Xuan Li¹, Si-Liang Jiang¹, Yan-Xia Hao, Si-Pei Zhang, Yong-Sheng Cui, Zheng Fu, Chun-Lan Xue, Cai-Xia Dong^*, Zhi Yao^e*, Juan Du^a*,Galactofucoidans from Sargassum fusiforme and their antagonistic effects against the proliferation-inhibition of RAW264.7 macrophage induced by culture supernatants of melanoma cells. Carbohydrate Polymer Technologies and Applications, 2021, 2:100090.

2. Yong-Sheng Cui^a#, Lixia Zhu^b,#, Qili Sun^a,c, Yixuan Li^a,c, Siliang Jiang^a,c, Hubiao Chen^b, Zhongzhen Zhao^b, Wei Qiao^a, Jun Xu^b,d,*, Caixia Dong^a,* Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota. Carbohydrate Polymers. 2021, 255: 117389.

3. Qili Sun^a,c,#, Lixia Zhu^b,#, Yixuan Li^a,c, Yongsheng Cui^a, Siliang Jiang^a,c, Ning Tao^d, Hubiao Chen^b, Zhongzhen Zhao^b, Jun Xu^b,*, Caixia Dong^a,*, A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota, Carbohydrate Polymers. 2020, 247, 116761.

4. Kai Zhou, Hailiqian Taoerdahong,^* Jie Bai, Ayixiaguli Bakasi, Xiaojing Wang, Caixia Dong,* Structural characterization and immunostimulatory activity of polysaccharides from Pyrus sinkiangensis Yu. International Journal of Biological macromolecules. 2020, 157:444-451.

5. Ying Zhang, Yan Zeng*, Yongsheng Cui, Hanmin Liu, Caixia Dong*, Yuanxia Sun. Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley. Carbohydrate Polymers. 2020, 235:115969.

6. Qi-Li Sun, Yi Li, Long-Quan Ni, Yi-Xuan Li, Yong-Sheng Cui, Si-Liang Jiang, En-Yi Xie, Juan Du, Fei Deng*, Cai-Xia Dong*. Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum. Carbohydrate Polymers. 2020, 229:115487.

7. Qi-Li Sun, Yi-Xuan Li, Yong-Sheng Cui, Si-Liang Jiang, Cai-Xia Dong*, Juan Du *. Structural characterization of three polysaccharides from Codonopsis pilosula and their immunomodulatory effects on RAW264.7 macrophages. International Journal of Biological macromolecules. 2019, 130:556-563.

8. Wen-Sheng Zhang, Qi-Li Sun, Wei Zheng, Yuan Zhang, Juan Du, Cai-Xia Dong*, Ning Tao*. Structural characterization of a polysaccharide from Coreopsis tinctoria Nutt. and its function to modify myeloid derived suppressor cells. International Journal of Biological macromolecules. 2019, 126:926-933.

9. Cai-Xia Dong*, Wen-Sheng Zhang, Qi-Li Sun, Yun-Jia Jiang, Zheng Fu, Ying Zhang, Juan Du, Yuanxia Sun, Ning Tao*, Zhi Yao*. Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression. International Journal of Biological macromolecules. 2018, 115:1233-1240.

10. Zhuo-Er Chen, Reziyamu Wufuer, Jin-Hu Ji, Jin-Fang Li, Yu-Feng Cheng,Cai-Xia Dong*, Hailiqian Taoerdahong*. Structural characterization and immunostimulatory activity of polysaccharides from Brassica rapa L. Journal of Agricultural and Food Chemistry.2017. 65(44):9685-9692.

     

     

    Grants

Ongoing:

1. The molecular mechanism of Curcuma kwangsiensis polysaccharide (CKAP-2) reversing the immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) (National Natural Science Foundation of China, No. 81803682, 1/1/2019-31/12/2021).

2. Study on the promotion of necroptosis mechanism against non-small cell lung cancer based on RIP-MLKL on acid polysaccharides in Brassica rapa L. (National Natural Science Foundation of China, No. 81960765,  01/01/2020-31/12/2023).

Completed:

1. Study on the medcicinal material base and mechanism of Sagassum henslowianum against Herpes simplex virus type II (Natural Science Foundation of Tianjin, No. 15JCYBJC50700,  1/4/2015-31/3/2018).

2. Construction of Curcuma kwangsiensis polysaccharide CKAP-2 carrier targeting myeloid-derived suppressor cells (MDSCs) (Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnosis, No. CTD2018-03,  2018.12-2020.11).