Hong-Quan Duan
School of Pharmacy, Research Center of Basic Medical Sciences, TianjinMedicalUniversity
22 Qixiangtai Road, Heping District
Tianjin 300070, P.R. China
(022) 83336680 (O), (022) 83336560 (Fax)
duanhq@
EDUCATION
Ph. D. Faculty of Pharmaceutical Sciences, University of Tokushima, Japan, 2000
MS, Faculty of Pharmaceutical Sciences, University of Tokushima, Japan, 1997
BS, School of Pharmacy, Tianjin Medical University, China, 1988
PROFESSIONAL EXPERIENCES
School of Pharmacy, Tianjin Medical University, Tianjin, China, 2004~, vice-dean, Professor
The College of Pharmaceuticals & Biotechnology, TianjinUniversity,Tianjin, China, 2001~2003, Professor
Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan, 2000-2001, Scientist
Institute of Medical and Pharmaceutical Sciences of Tianjin, Tianjin, P.R. China, 1988-1993, assistant
MAJOR PUBLICATIONS:
1). Sesquiterpene alkaloids from Tripterygium hypoglaucum;Hongquan Duan, Kazuyoshi Kawazoe and Yoshihisa Takaishi, Phytochemistry, 1997, 45, 617-621.
2). Di-and Triterpenoids from Tripterygium hypoglaucum; Hongquan Duan, Kazuyoshi Kawazoe, Masahiko Bando, Masaru Kido and Yoshihisa Takaishi, Phytochemistry, 1997, 46, 535-543.
3). Structures of sesquiterpene polyol alkaloids from Tripterygium hypoglaucum; Hongquan Duan and Yoshihisa Takaishi, Phytochemistry, 1998, 49, 2185-2189.
4). Sesquiterpene evoninate alkaloids from Tripterygium hypoglaucum; Hongquan Duan and Yoshihisa Takaishi, Phytochemistry, 1999, 53, 1735-1738.
5). Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: a new class of potent anti-HIV agents; Hongquan Duan, Yoshihisa Takaishi, Masahiko Bando, Masaru Kido, Yasuo Imakura and KuoHsiung Lee, Tetrahedron Letters, 1999, 40, 2969-2972.
6). Immunosuppressive diterpenoids from Tripterygium wilfordii; Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao,Taki, Yongfeng Jia, and Duan Li, Journal of Natural Products, 1999, 62,1522-1525.
7). Sesquiterpene alkaloids from extracts of Tripterygium wilfordii; Hongquan Duan, Yoshihisa Takaishi, Yongfong Jia, and Duan Li, Chem. Pharm. Bull 1999, 47 (11), 1664-1667.
8). Sesquiterpene alkaloids from Tripterygium hypoglaucum and T. wilfordii: a new class of potent anti-HIV agents; Hongquan Duan, Yoshihisa Takaishi, Yasuhiro Imakura, Yongfong Jia, Duan Li, L. Mark Cosentino, Kuo-Hsiung Lee, Journal of Natural Products, 2000, 63, 357-361.
9). Tripterpenoids from Tripterygium wilfordii; Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Yongfeng Jia and Duan Li, Phytochemistry, 2000, 53, 805-810.
10). Sesquterpene polyol esters from Tripterygium wilfordii; Hongquan Duan, Yoshihisa Takaishi, Yong-Feng Jia and Duan Li, Phytochemistry, 2001, 56, 341-346.
11). Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii; Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Yongfeng Jia and Duan Li, Journal of Natural Products, 2001, 64, 582-587.
12). Immunosuppressive constituents from Saussurea medusa; Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki, Phytochemistry, 2002, 59, 85-90.
13). Immunosuppressive Terpenoids from Extracts of Tripterygium wilfordii;Hongquan Duan, Yoshihisa Takaishi, Hiroshi Momota, Yasukazu Ohmoto, Takao Taki,Motoo Tori, Shigeru Takaoka, Yongfeng Jia, and Duan Li, Tetrahedron, 2001, 57, 8413-8424.
14). Chemical Constituents from Colombia medicinal plant Niphogeton ternate;Hongquan Duan, Yoshihisa Takaishi, Yoshinori Fujimoto, Cristina Garzon, Coralia Osowio, Carmenza Duque, Chem. Pharm. Bull, 2002, 50, 115-117.
15). Polysulfide Derivatives from Ferula foetida; Hongquan Duan,Yoshihisa Takaishi,Motoo Tori, Shigeru Takaoka, Gisho Honda, Michiho Ito,Yoshio Takeda, Olimjon K. Kodzhimatov, K. Kodzhimatov, and Ozodbek Ashurmetov, Journal of Natural Products, 2002, 65, 1667-1669.
16). Terpenoids from Tripterygium wilfordii; Kunhua Li, Hongquan Duan, Kazuyoshi Kawazoe and Yoshihisa Takaishi, Phytochemistry, 1997, 45, 791-796.
17). Terpenoids from Tripterygium wilfordii var. regelii; Yoshihisa Takaishi, Kaname Miyagi, Kazuyoshi Kawazoe, Kimiko Nakano, Kunhua Li and Hongquan Duan, Phytochemistry, 1997, 45, 975-978.
18). Phenolic diterpenes from Tripterygium wilfordii var. regelii; Yoshihisa Takaishi, Noriko Wariishi, Hideo Tateishi, Kazuyoshi Kawazoe, Kaname Miyagi, Kunhua Li and Hongquan Duan, Phytochemistry, 1997, 45, 979-984.
19). Triterpene caffeoyl esters and diterpenes from Celastrus stephanotifolius; Bei Chen, Hongquan Duan and Yoshihisa Takaishi, Phytochemistry, 1999, 51, 683-687.
20). Phenylpropanol derivatives from Morina chinensis; BaoNing Su, Yoshihisa Takaishi, Hongquan Duan and Bei Chen, Journal of Natural Products, 1999, 62, 1363-1366.
21). Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release; Ping Zhou, Yoshihisa Takaishi, Hongquan Duan, Bei Chen, Gisho Honda, Minchiho Itoh, Yoshio Takeda, Olimjon K. Kodzhimatov, Kuo-Hsiung Lee, Phytochemistry, 2000, 53, 689-697.
22). Terpenoids from Tripterygium hypoglaucum; Reiko Fujita, Hongquan Duan and Yoshihisa Takaishi, Phytochemistry, 2000, 53, 715-722.
23). Limonoids from Citrus sudachi; Hiroyuki Nakagawa, Hongquan Duan and Yoshihisa Takaishi, Chem. Pharm. Bull, 2001, 49, 649-651.
24). Quality Control of Traditional Chinese Medicine, Wen Yuan Gao, Hong-Quan Duan, and Pei Gen Xiao, Frontiers of Biotechnology & Pharmaceuticals 2002, Volume three, Science Press New York Ltd, NY, USA, pp152.
25). Terpenoids from Tripterygium doianum (Celastraceae), Naonobu Tanaka, Hongquan Duan, Yoshihisa Takaishi, Phytochemistry, 2002, 61, 93-98.
26).Good Agriculture Practice (GAP) and Sustainable Resource Utilization of Chinese Materia Medica, Wenyuan Gao, Wei Jia, Hongquan Duan, Luqi Huang, Xiaohe Xiao, Peigen Xiao, Kee-Yoeup Peak, Journal of Plant Biotechnology 2002, 4, 103-107.
27).Immunosuppressive Diterpenes from Veronicastrum sibiricum Wenyuan GAO,Rong ZHANG, Wei JIA,Jun ZHANG, Yoshihisa TAKAISHI, Hongquan DUAN,*Chem. Pharm. Bull. 2004, 52 (1), 136-137.
28).Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae), Naonobu Tanaka, Nbuyuki Ooba, Hongquan Duan, et al, Phytochemistry, 2004, 65, 2071-2076.
29).TERPENE ALKALOIDS FROM TRIPTERYGIUM WILFORDII, XIAO-DONG WANG and HONG-QUAN DUAN,*et al., JANPR, 2005, 7(5), 755-759.
30).Immunosuppressive sesquiterpenes from Tripterygium wilfordii, Chem. Pharm. Bull., Xiaodong Wang, Hongquan Duan* et al., 2005, (53)6,607-610.
31).A New Hemiterpene Derivative from Prinsepia utilis，Junyi HU, Hongquan DUAN*，Chinese Chemical Letters, 2006，17 (2)，198-200.
32). (17S)-2, 3, 18, 23, 24-pentahydroxy-19(18-17)-abeo-28- norolean-12- en-21-one from the rhizome of Phlomis umbrosa, Pu Liu, Hong-Quan Duan* et al., Acta Cryst. 2006, E62, o919-921.
33).TWO EUDESMANE SESQUITERPENES FROM LAGGERA PTERODONTA, YONG-BIN LIU,HONG-QUAN DUAN* et al, JANPR, 2006, 8（4），303-307。
34).Two New Triterpenes from Astilbe chinensis，Junyi HU, Hongquan DUAN*，et al., Chinese Chemical Letters, 2006,17(5), 628-630.
35).A novel triterpene from Centella asiatica, Quan-Lin Yu, Hong-Quan Duan, Yoshihisa Takaishi, Wen-yuan Gao, molecules, 2006, 11, 661-665.
36).hree New Cycloartane Triterpene Glycosides from Actaea asiatica, Yun Shuang FAN, Hong Quan DUAN *, et al., Chinese Chemical Letters, 2006, 17(11),1477-1480.
37).Two eudesmane derivatives from Laggera pterodonta，YONG-BIN LIU, HONG-QUAN DUAN*，et al, JANPR, 2007, 9(3), 233-237.
38).Antitumor constituents from Alternanthera philoxeroides, Jin-bo Fang, Wei Jia, Hong-quan Duan*, et al, JANPR, 2007, 9(6), 511-515.
39) Immunosuppressive terpenes from Prinsepia utilis, Ying-Qian Xu, Hong-Quan Duan* et al, JANPR, 2007, 9(7), 637-642.
40) Mass Spectrometry-Based Metabllic Profiling of Rat Urine Associated with General Toxicity Induced by the Multiglycoside of Tripterygium wilfordii Hook f., Minjun Chen, Yan Ni, Hongquan Duan, Wei Jia，et al, Chem. Res. Toxicol. 2008, 21, 288-294.
41).Antitumor triterpene saponins from Anemone flaccida, Lan Tian Zhang, Hongquan Duan*, et al, Chinese Chemical Letters, 19 (2008)190-192.
42).Cytotoxic triterpene saponins from Altermanthera philoxeroides, Jin-Bo Fang, Zhi Yao, Hong-Quan Duan*, et al., JANPR, 2009, 11(3), 261-266.
43).Wen zhang, zhi yao, yanwen zhang, xing xiang zhang, Yoshihisa Takaishi, Hong quan duan*. Immunosupressive sequiterpenes from Buddleja daviddi Planta Med， 2010，76: 1-6.
44).Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents, Yujin Zhu, Yanjun Zhang, Yi Liu, Hongwan Chu and Hongquan Duan*, Molecules 2010, 15, 9174-9183.
45).A new labdanic norditerpene from Pinus sylvestris, Teng J, Zhang R, Zhang YW, Duan Hong-Quan*, Takaishi Y., Nat Prod Res. 2010 Oct;24(17):1587-91.
46).Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells, Lihuan Shi, Nan Qin, Lijuan Hua, Linjuan Liu, Hongquan Duan **, Wenyan Niu*, Diabetes research and clinical practice 92(2011) e41– e46.
47).Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis, Wei Qiao, Chuan Zhao, Nan Qin, Hui Yuan Zhai, Hong Quan Duan∗,Journal of Ethnopharmacology，135 (2011) 515–521.
48).Isolation of Novel Phenolic Compounds with Multidrug Resistance (MDR) Reversal Properties from Onychium japonicum by Ming-Chan Li, Zhi Yao, Yoshihisa Takaishi, Shen-An Tang, and Hong-Quan Duan*，CHEMISTRY & BIODIVERSITY – Vol. 8 (2011), 1112-1120.
49).Synthesis and biological activity of novel tiliroside derivants. Eur J Med Chem. 2011 Aug 7. [Epub ahead of print], Qin N, Li CB, Jin MN, Shi LH, Duan HQ*, Niu WY**.Vol. 46 (2011), 5189-5195.
50). Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone, Dexin Kong*, Takao Yamori, Motomasa Kobayashi, Hongquan Duan, Mar. Drugs 2011, 9, 1-x; doi:10.3390/md90x000x
51) Alkaloids from Pachysandra terminalis Inhibit Breast Cancer Invasion and Have Potential for Development As Antimetastasis Therapeutic Agents. Zhai HY, Zhao C, Zhang N, Jin MN, Tang SA, Qin N, Kong DX, Duan HQ*.J Nat Prod. 2012 Jul 27; 75(7):1305-11.
52) Lignans from Schisandra propinqua with inhibitory effects on lymphocyte proliferation.Jin MN, Yao Z, Takaishi Y, Duan HQ*. Planta Med. 2012 May; 78 (8):807-13.
53) Synthesis and antidiabetic activity of 5,7-dihydroxyflavonoids and analogs. Chang LS, Li CB, Qin N, JinMN, Duan HQ*. Chem Biodivers. 2012 Jan;9(1):162-9.
54) Four new triterpenes from the endemic relict shrub Tetraena mongolica, Sheng-An Tang, Lin-Lin Ding, Hui-Yuan Zhai, Nan Qin, Hong-Quan Duan*, Journal of Asian Natural Products Research, 2012, Aug, 1-6, DOI:10.1080/10286020.2012.699525.
55) A NEW TRITERPENE FROM Astilbe chinensis, Ying Qian Xu, Song Pang, Jun-Yi Hu, and Hong Quan Duan*, Chemistry of Natural Compounds, Vol. 49, No. 2, May, 2013.
56) Flavonoids from Tetrastigma obtectum enhancing glucose consumption in insulin-resistance HepG2 cells via activating AMPK, Mei-Na Jin, Guo-Ru Shi, Sheng-An Tang, Nan-Qin , Wei Qiao, Hong-Quan Duan*, Fitoterapia 90 (2013) 240–246.
57) Novel Cell Membrane Capillary Chromatography for Screening Active Compounds from Natural Products，Cheng Tang, Zhao-Sheng Liu, Nan Qin, Liang Xu*, Hong-Quan Duan*, Chromatographia (2013) 76:697–701. DOI 10.1007/s10337-013-2462-2.
58) Construction of supramolecular nanofibers through electrostatic interaction between perylene and cholesterol derivatives, Min Han, Guo-Cheng Wang, Hong-Quan Duan*, Chinese Chemical Letters, Volume 25, Issue 1, January 2014, Pages 51-54.
59) Anti-inflammatory Terpenes from Flowers of Inula Japonica, Sheng-An Tang, Hong Zhu, Nan Qin, Jing-Ya Jing, Eunkyung Lee, De-Xin Kong, Mei-Hua Jin*, Hong-Quan Duan*, Planta Medica, 2014, 80, 583-589.
60) Antitumor metastasis pregnane alkaloids from Pachysandra terminalis, Zhao C, Gan CC, Jin MN, Tang SA, Qin N, Duan HQ*, J Asian Nat Prod Res. 2014;16(5): 440-6. doi: 10.1080/10286020.2014.893511.
61) Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives,Hai-Jun Fang, Qian Liu, Chun-Chun Gan, Mei-Na Jin, *Nan Qin, *Hong-Quan Duan，Letters in Drug Design & Discovery，2014, 11:395-402.
62) SYNTHESIS AND ANTIMETASTATIC EFFECT OF E-SALIGNONE,Jia Liu, Sheng-Nan Ma, Xiang Zhang, Mei-Na Jin, Mei-Hua Jin, Dexin Kong*, Nan Qin*, and Hong-Quan Duan*, Chemistry of Natural Compounds, Vol. 50, No. 4, September, 2014 [Russian original No. 4, July–August, 2014].
63) A NEW AURONE FROM Smilax riparia, Wen Chen, Xiao-Ai Shou, Ying Chen, Nan Qin, Wei Qiao, Sheng-An Tang*, and Hong-Quan Duan*, Chemistry of Natural Compounds, Vol. 50, No. 6, December, 2014,859-862.[Russian original No. 6, November–December, 2014].
64) Synthesis and Antimetastatic Effects of E-Salignone Amide Derivatives, Hong-Ling Wang, Nan Qin, Jia Liu, Mei-Na Jin, Xiang Zhang, Mei-Hua Jin, Dexin Kong, Shen-De Jiang, and Hong-Quan Duan*, DRUG DEVELOPMENT RESEARCH, 2014, 75(2):76-87.
65) PENANGIANOL A AND B: TWO NEW NORLIGNANS FROM RHIZOMES OF Abacopteris penangiana, Yang Jiao, Jinbo Fang, Shengan Tang,*and Hongquan Duan* Chemistry of Natural Compounds, 2015, 51(2), 232-235.
66) Synthesis and anti-metastatic effects of novel chiral ionone alkaloid derivatives, Hai-Jun Fang, Xiao-Ai Shou, Qian Liu, Chun-Chun Gan, Hong-Quan Duan,* Nan Qin**, European Journal of Medicinal Chemistry ,2015,101, 245-253.
67) A NEW MEGASTIGMANE ALKALOID FROM Pachysandra terminalis WITH ANTITUMOR METASTASIS EFFECT, Mei-Na Jin, Sheng-Nan Ma, Hui-Yuan Zhai, Nan-Qin, Hong-Quan Duan* and De-Xin Kong*, Chemistry of Natural Compounds, 2015, 51(2), 311-315.
68) Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice ,Chen Y, Zhang C, Jin MN, Qin N, Qiao W, Yue XL, Duan HQ*, Niu WY*.. Nat Prod Res. 2015, 29,1-5.
69) Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice. Qin N, Chen Y, Jin MN, Zhang C, Qiao W, Yue XL, Duan HQ*, Niu WY. Eur J Pharm Sci. 2016, 20(82),52-63.
70) Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis, Xiang-Yu Li, Yang Yu, Miao Jia, Mei-Na Jin, Nan Qin, Chuan Zhao* and Hong-Quan Duan*, Molecules , 2016, 21(10), 1283-1294.
71) Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives. Qin N*, Jia M, Wu XR, Shou XA, Liu Q, Gan CC, Jin MN, Yu Y, Duan HQ*. Eur J Med Chem. 2016, 124(29), 490-499.
72) 72)Two new eunicellin diterpenoids from the East China Sea gorgonian Muricella sp. Zhao Chuan, Wang Jia,Jin De-Jun, Duan Hong-Quan, Xing Guo-Sheng, Tang Sheng-An, Journal Of Asian Natural Products Research, 2016, 18(9),848-853.
73) 73) Flavonoid derivative (Fla-CN) inhibited adipocyte differentiation via activating AMPK and up-regulating microRNA-27 in 3T3-L1 cells, Chun-Chun Gan, Tian-Wen Ni, Yang Yu, Nan Qin, Ying Chen, Mei-Na Jin*, Hong-Quan Duan*, European Journal of Pharmacology, 2017, 797, 45-52.
74) 74) 1,6-O,O-Diacetylbritannilactone suppresses activation of mast cell and airway hyper-responsiveness，
75) Immunopharmacology And Immunotoxicology.Jin, Meihua, Kim, Sungun, Qin, Nan, Chen, Xi, Ji, Ning, Tang, Sheng-an, Kong, Dexin, Lee, Eunkyung and Duan, Hongquan,Immunopharmacology And Immunotoxicology ,2017, 39(4),173-179.
76) 75) Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens, Jianbin Wang, Kehui Xie, Hongquan Duan, Yi Wang, He Ma, Hong zheng Fu, Bioorganic & Medicinal Chemistry Letters, 2017,27(8):1815-1819.
77) 76) Axinellin A and B: Two New Pyrrolactam Alkaloids from Axinella sp. Xu WG, Xu JJ, Wang J, Xing GS, Qiao W, Duan HQ, et al. Chem Nat Compd. 2017;53(2),325-327.
78) 77) Synthesis and anti-inflammatory activities of 1-O-acetylbritannilactone analogues. Xiao-Peng Wei,Yu-Fen Chen,Hong Zhu, Xiao-Ran Wu, Yang Yu, De-Xin Kong, Hong-Quan Duan*, Mei-Hua Jin, Nan Qin*, Phytochem Lett. 2017,19, 248-53.
79) 78) ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens,Jianbin Wang, Hongquan Duan, Yi Wang, Bowen Pan, Chun Gao, Chunyan Gai, Qiong Wu, and Hongzheng Fu,J. Nat. Prod., 2017, 80 (1), 19-29.
79） The synthesis and anti-metastatic effects of optical isomers of ionone alkaloid 9-(N,N-dimethyl)-4,7-megastigmedien-3-one, Xiao-Ran Wu, Wen Zhu, Hong-Zheng Fu, Hong-Quan Duan*, Nan Qin*, Fitoterapia. 2018 Jun;127:1-6. doi: 10.1016/j.fitote.
80） AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells, Chang Zhang，Jia Liu, Meina Jin,, Nan Qin, Ying Chen, Wenyan Niu*, Hongquan Duan*, Drug Design, Development and Therapy 2018,12, 1581-1587.
81） Flavonoid derivatives synthesis and anti-diabetic activities,Ying Chen, Feng-Bo Cheng, Xiao-Ran Wu, Wen Zhu, Jian-Wen Liao, Yue Jiang,Chang Zhang, Wen-Yan Niu, Yang Yu, Hong-Quan Duan*, Nan Qin*,Bioorganic Chemistry 95 (2020) 103501.
82） Zhang C#, Luo X#, Zhang D, Deng B, Tong J, Zhang M, Chen L, Duan H, Niu W*. et al. Hypoxic adipocytes induce macrophages to release inflammatory cytokines that render skeletal muscle cells insulin resistant. Biochem Biophys Res Commun. 2020 Jan 15;521(3):625-631.
83） Discovery and anti-diabetic effects of novel isoxazole based flavonoid
Derivatives, Jiang-Ping Nie, Zhen-Ni Qu, Ying Chen, Jia-Hao Chen, Yue Jiang, Mei-Na Jin, Yang Yu,Wen-Yan Niuc, Hong-Quan Duan*, Nan Qin.Fitoterapia 142 (2020) 104499.
84） Discovery of Anti-metastatic Chiral Ionone Alkaloid Derivatives Targeting HIF-1α/VEGF/VEGFR2 Pathway, Jing-Jing Liu#, Xin-Yao Liu#, Jiang-Ping Nie, Mei-Qi Jia, Yang Yu, and Nan Qin1*, Hong-Quan Duan*, 16，2020-12-01，ChemMedChem.
85） Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis bytargeting HSP90α, Tian-Wen Ni1, #, Xiao-Chuan Duan#, Meng Wang, Mei-Qi Jia, Ying Chen, Yang Yu, Nan Qin*, Hong-Quan Duan*,Bioorganic chemistry, 115 (2021) 105201.
