Xianhua Wang, Ph.D.
Xianhua Wang,PhD
Associate professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300072
Phone: +86-22-83336675
Email: wangxianhua@tmu.edu.cn
Education
BS Tianjin Medical University, Tianjin, China, 2007
MD Tianjin University, Tianjin, China, 2009
Ph.D. Tianjin University, Tianjin, China, 2013
Professional Experience
2013- Lecturer, School of Pharmacy, Tianjin Medical University, Tianjin, China
2008/07-2009/06 Training personnel, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China
2019- Associate professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
Research Interest
Design and application of advanced intelligent materials for disease diagnosis and treatment
Honors
1. Tianjin Medical University science and technology award (KG15001-3)
2. Tianjin Medical University science and technology award (KG18002-3)
Professional Service
Lecture course - Analytical Chemistry
Reviewer for:
Journal of Chromatography A
Process Biochemistry
Biomedical Chromatography
Arabian Journal of Chemistry
Journal of Separation Science
Publication
1. Yi Luo, Chen-Chen Bai, Ming-Xia Liu, Di Wang, Meng-Ying Chen, Shi-Song Yu, Xin-Ying Bu, Xian-Hua Wang*,PEGylation of boronate-affinity-oriented surface imprinting magnetic nanoparticles with improved performance, Talanta, 2022, 238, 122992.
2. Lu-Xia Zhang, Rui Duan, Yuan-Shuo Yang, Chao Peng, Lin-Yi Dong*, Xian-Hua Wang*, Rapid and ultrasensitive detection of ellagic acid by integrating boronate-affinity controllable-oriented imprinted magnetic nanoparticle and boronic acid-modified / polyethylene glycol-coated allochroic-graphene oxide, Sensors & Actuators: B. Chemical, 2021, 345, 130400.
3. Chen-Chen Bai, Di Wang, Ming-Xia Liu, Yi-Rong Ma, Yi Sun, Rui Duan, Lin-Yi Dong*, Xian-Hua Wang*, Ultrasensitive and specific detection of glycoprotein with boronic acid-modified / fluorescein isothiocyanate-loaded graphene oxide as signal amplification matrix, Sensors & Actuators: B. Chemical, 2021, 344, 130327.
4. Xiyan Deng, Min Zeng, Xuan Wang, Jiyang Liu, Yuanchun Ma, Xian-Hua Wang*，Liang Xu*, Preparation of cyclic citrullinated peptide-immobilized latex beads for measurement of anti-citrillinated protein antibody through latex particle-enhanced turbidimetric immunoassay, Journal of Chromatography A, 2021, 1642, 462000.
5. Lu Sun, Chao Peng, Yi Luo, Liwei Chen, Ziye Chen, Manyu Xiao, Rui Duan, Lin-Yi Dong*, Hua Guo*, Xian-Hua Wang*, Visual detection of hepatocellular carcinoma cells with cell imprinted substrate and pH-sensitive allochroic-graphene oxide, Materials Science and Engineering: C, 2021, 123, 111966.
6. Liang Xu*, Zhan-Song Hu, Rui Duan, Yuan-Shuo Yang, Lin-Yi Dong, Xian-Hua Wang*, Advances and Applications of In-tube Solid-phase Microextraction for Analysis of Proteins,Journal of Chromatography A, 2021, 1640, 461962.
7. Rui Duan, Chao Peng, Lu Sun, Lu-Xia Zhang, Chen-Chen Bai, Lin-Yi Dong*, Xian-Hua Wang*, Integrating boronate affinity controllable-oriented surface imprinting nylon wire and pH-triggered allochroic-graphene oxide for ultrasensitive detection of glycoprotein, Sensors & Actuators: B. Chemical, 2021, 330, 129310.
8. Yu Fan, Yan Zhang, Chao Peng, Xiao Chang, Lu Sun, Xiang-Jin Kong, Bao-Zhong Zhang*, Lin-Yi Dong, Xian-Hua Wang*, Preparation of teamed boronate affinity magnetic nanoparticles for extraction of polyphenols from Flos Lonicerae Beverage under neutral pH prior to their determination by high-performance liquid chromatography-mass spectrometry, Journal of Chromatography A, 2020, 1619, 460913
9. Rui Duan, Lu Sun, Hui-Yuan Yang, Yi-Rong Ma, Xi-Yan Deng, Chao Peng, Chao Zheng, Lin-Yi Dong*, Xian-Hua Wang*, Preparation of phenyl-boronic acid polymeric monolith by initiator-free ring-opening polymerization for microextraction of sulfonamides prior to their determination by UPLC-MS/MS, Journal of Chromatography A, 2020, 1609, 460510.
10. Lu Sun, Rui Duan, Yu Fan, Xin-Zhu Chen, Chao Peng, Chao Zheng, Lin-Yi Dong*, Xian-Hua Wang*,Preparation of magnetic mesoporous epoxy resin by initiator-free ring-opening polymerization for extraction of bile acids from human serum, Journal of Chromatography A, 2020, 1609, 460448.
11. Xiang-Jin Kong, Chao Peng, Yao-Han Lan, Wen-xiu Li, Shuai-Shuai Chi, Chao Zheng, Lin-Yi Dong*, Xian-Hua Wang*, Boronate decorated membrane via atom transfer radical polymerization for separation and enrichment of polyphenols from tea drinks. Analytical Methods,2019, 11, 4116-4125.
12. Chao Peng, Yao-Han Lan, Lu Sun, Xin-Zhu Chen, Shuai-Shuai Chi, Chao Zheng, Lin-Yi Dong*, Xian-Hua Wang*, Facile synthesis of boronate affinity-based molecularly imprinted monolith with reduced capturing pH towards cis-diol-containing compounds. Chromatographia, 2019, 82, 1029-1040. (Correspondence author)
13. Liang Xu, Cheng Tang, Xin Li, Xiaofan Li, Huiping Yang, Ruizhi Mao, Jiahui He, Wanqing Li, Jiyang Liu, Yalong Li, Shuobo Shi, Xuefeng Xiao*, Xianhua Wang*, Ligand fishing with cellular membrane-coated cellulose filter paper: a new method for screening of potential active compounds from natural products. Analytical and Bioanalytical Chemistry, 2019, 411, 1989-2000. (Paper in Forefront) (Correspondence author)
14. Shuai-Shuai Chi1, Chao Peng 1, Yao-Han Lan, Hui-Yuan Yang, Xin-Zhu Chen, Luo-Bing Han, Chao Zheng, Lin-Yi Dong*, Xian-Hua Wang*, Preparation of phenyl-boronic acid polymer monolith by initiator-free ring-opening polymerization for microextraction of sulfamethoxazole and trimethoprim from animal-originated foodstuffs, Journal of Chromatography A, 2019, 1590, 10-19. (Correspondence author)
15. Ling-Ling Ying1, De-Yin Wang1, Hui-Ping Yang, Xi-Yan Deng, Chao Peng, Chao Zheng, Bei Xu, Lin-Yi Dong, Xu Wang, Liang Xu*, Yan-Wen Zhang,Xian-Hua Wang*, Synthesis of boronate-decorated polyethyleneimine-grafted porous layer open tubular capillaries for enrichment of polyphenols in fruit juices, Journal of Chromatography A, 2018, 1544, 23-32. (Correspondence author)
16. Qian Dong1, Shuai-Shuai Chi1, Xi-Yan Deng, Yao-Han Lan, Chao Peng, Chao Zheng, Lin-Yi Dong, Xian-Hua Wang*, Boronate affinity monolith via two-step atom transfer radical polymerization for specific capture of cis-diol-containing compounds, European Polymer Journal, 2018, 100, 270-277. (Correspondence author)
17.Xiang-Jin Kong1, Chao Zheng1, Yao-Han Lan, Shuai-Shuai Chi, Qian Dong, Hao-Long Liu, Chao Peng, Lin-Yi Dong, Liang Xu, Xian-Hua Wang*, Synthesis of multi-recognition magnetic molecularly imprinted polymer by atom transfer radical polymerization and its application in magnetic solid phase extraction, Analytical and Bioanalytical Chemistry,2018, 410, 247-257.(Correspondence author)
18.Liang Xu*, Bei Xu, Zhi-Yu Zhao, Hui-Ping Yang, Cheng Tang, Lin-Yi Dong, Kun Liu, Li Fu*, Xian-Hua Wang*, Preparation and characterization of micro-cell membrane chromatographic column with N-hydroxysuccinimide group-modified silica-based porous layer open tubular capillary, Journal of Chromatography A, 2017, 1516, 125-130.(Correspondence author)
19.Ling-Ling Ying, Yuan-Chun Ma, Bei Xu, Xian-Hua Wang*, Lin-Yi Dong, Dong-Mei Wang, Kun Liu, Liang Xu*, Poly(glycidyl methacrylate) nanoparticle-coated capillary with oriented antibody immobilization for immunoaffinity in-tube solidphase microextraction: preparation and characterization, Journal of Chromatography A, 2017,1509, 1-8.(Correspondence author)
20.Xian-Hua Wang*, Lei Tang, Fang-Fang Yang, Ling-Ling Ying, Yan-Ping Huang*, Zhao-Sheng Liu, Green synthesis of water-compatible and thermo-responsive molecularly imprinted nanoparticles, European Polymer Journal, 2017, 92, 174-184. (Correspondence and first author)
21.Xian-Hua Wang*, Qian Dong, Ling-Ling Ying, Shuai-Shuai Chi, Yao-Han Lan, Yan-Ping Huang, Zhao-Sheng Liu*, Enhancement of selective separation on molecularly imprinted monolith by molecular crowding agent. Analytical and Bioanalytical Chemistry, 2017, 409(1), 201-211.(Correspondence and first author)
22.Jing Zhang, Fang Li, Xian-Hua Wang*, Dan Xu, Yan-Ping Huang, Zhao-Sheng Liu*, Preparation and characterization of dual-template molecularly imprinted monolith with metal ion as pivot, European Polymer Journal, 2016, 80, 134-144.(Correspondence author)
23. Xian-Hua Wang, Li-Fu Xie, Qian Dong, Hao-Long Liu, Yan-Ping Huang, Zhao-Sheng Liu*, Synthesis of monodisperse molecularly imprinted microspheres with multi-recognition ability via precipitation polymerization for the selective extraction of cyromazine, melamine, triamterene and trimethoprim,Journal of Chromatography B, 2015, 1007, 127-131.(First author)
24.Xian-Hua Wang, Jing Zhang, Chao Peng, Qian Dong, Yan-Ping Huang, Zhao-Sheng Liu*, Comparison of multi-recognition molecularly imprinted polymers for recognition of melamine, cyromazine, triamterene, and trimethoprim, Analytical and Bioanalytical Chemistry, 2015, 407(23), 7145-7155.(First author)
25. Lu Ban, Xu Han, Xian-Hua Wang*, Yan-Ping Huang, Zhao-Sheng Liu*, Carprofen-imprinted monolith prepared by reversible addition-fragmentation chain transfer polymerization in room temperature ionic liquids, Analytical and Bioanalytical Chemistry, 2013, 405 (26), 8597-8605.(Correspondence author)
26. Xian-Hua Wang, Qiu-Xue Fang, Shi-Peng Liu, Lei Chen*, The application of pseudo template molecularly imprinted polymer to the solid-phase extraction of cyromazine and its metabolic melamine from egg and milk, Journal of Separation Science, 2012, 35(12), 1432-1438. (First author)
27. Xian-Hua Wang, Qiu-Xue Fang, Shi-Peng Liu, Lei Chen*, Preparation of magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples, Analytical and Bioanalytical Chemistry, 2012, 404 (5), 1555-1564.(First author)
Grant
Ongoing:
1. Project supported by enterprise, Study on pharmacokinetics of carboxymaltose iron, Exec Date 2021.11-2023.10, Principle Investigator, ¥60,000;
2. Project supported by enterprise, Development of collagen fermentation lysate for skin repair for medical devices, Exec Date 2021.07-2023.07, Principle Investigator, ¥240,000;
3. Project supported by enterprise, Development of detection method for hepatocholic acid in biological samples, Exec Date 2020.09-2022.09, Principle Investigator, ¥45,000;
4. Project supported by enterprise, Study on chemical methods of stone samples, Exec Date 2020.01-2021.12, Principle Investigator, ¥90,000.
Completed:
1. Project supported by National Natural Science Foundation of China, 21605114, Exec Date 2017.01-2019.12, Principle Investigator, ¥200,000;
2. Project supported by Tianjin Natural Science Foundation, 16JCQNJC05500, Exec Date 2016.4-2019.3, Principle Investigator, ¥60,000;
3. Project supported by enterprise, Study on drug adsorption of disposable precision filter infusion set, Exec Date 2019.06-2022.06, Principle Investigator, ¥120,000;
4. Project supported by enterprise, Development of a detection method for gallstone related target molecules, Exec Date 2018.04-2020.04, Principle Investigator, ¥80,000.
