Guifang Han, Assosciate Professor
发布人：药学院-英文  发布时间：2022-04-27   浏览次数:295


Guifang Han, Ph.D.

 

Guifang Han, PhD

Assosciate Professor

School of Pharmacy

Tianjin Medical  University

22 Qixiangtai Road

Tianjin 300070

Phone: 022-83336678

Email: hanguifang@tmu.edu.cn

 

Education

B.S.    Beijing University of Chemical Technology, Beijing, China, 2003-2007

Ph.D.  Nankai University, Tianjin, China, 2010-2015

 

Professional Experience

2007-2010     Associate Synthetic Chemist, WuXi AppTec, Tianjin, China

2015-2021     Lecturer, School of Pharmacy, Tianjin Medical University, Tianjin, China

2022-             Assosciate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China


Publication

  1. Yilin Zhao, Xue Wang, Ru Yao, Chengwen Li, Zelin Xu, Liming Zhang, Guifang Han,* Jingli Hou, Yangping Liu, Yuguang Song* Iron-catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of the Trifluoromethylated Spirocarbocycles. Adv. Synth. Catal. 2021, DOI: 10.1002/adsc.202101201

  2. Chengwen Li, Yilin Zhao, Jiaxin Zhou, Xue Wang, Jingli Hou, Yuguang Song, Wenjuan Liu and Guifang Han* Synthesis of Difluoroalkylated 2-Azaspiro[4.5]decanes Derivatives via Copper-Catalyzed Difluoroalkylation/ Dearomatization of N-Benzylacrylamides. Org. Biomol. Chem., 2020, 18, 8376–8380.

  3. Li Chengwen; Xue Li; Zhou Jiaxin; Zhao Yilin, Han Guifang*; Hou Jingli; Song Yuguang; Liu Yangping* Copper-Catalyzed Trifluoromethylation of Ynones Coupled with Dearomatizing Spirocyclization of Indoles: Access to CF3-Containing Spiro[cyclopentane-1,3’-indole], Org. Lett. 2020, 22, 3291−3296.

  4. Xing Wang,# Chao Peng,# Ke He, Kaiyun Ji, Xiaoli Tan, Guifang Han,* Yanxia Liu,*Yangping Liu  and Yuguang Song*. Intracellular delivery of liposome-encapsulated Finland trityl radicals for EPR oximetry. Analyst, 2020, 145, 4964–4971. 

  5. Yuying Qu, Yingchun Li, Xiaoli Tan, Weixiang Zhai, Guifang Han, Jingli Hou, Guoquan Liu, Yuguang Song,* and Yangping Liu* Synthesis and Characterization of Hydrophilic Trityl Radical TFO for Biomedical and Biophysical Applications. Chem. Eur. J.2019, 25, 7888 – 7895.

  6. Guifang Han, Lihua Qing, Meng Wu, Yuxiang Wang, Yuxiu Liu, Xueling Liu, Ziwen Wang, Jian Ding, Ling-hua Meng*, Qingmin Wang* Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents. Bioorganic & Medicinal Chemistry.2019, 27, 3070–3081.

  7. Guifang Han#, Li Xue#, Lili Zhao, Tiaozhen Zhu, Jingli Hou, Yuguang Song*,  Yangping Liu*Access to CF3‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction. Adv. Synth. Catal. 2019, 361, 678 –682.(VIP Paper)

  8. Jingli Hou, Haiyan He, Saipeng Huang, Meng Qian, Jie Wang, Xiaoli Tan, Guifang Han, Yuguang Song,* Zhelong Xu* and  Yangping Liu* A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury. Chem, Comm. 2019, 55, 1205-1208.

  9. Guifang Han, Linwei Chen, Qiang Wang, Meng Wu, Yuxiu Liu, and QingminWang*Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids. J. Agric. Food Chem., 2018, 66 (4), 780–788

  10. Yuxiu Liu, Lihua Qing, Chuisong Meng, Jiajie Shi, Yan Yang, Ziwen Wang, Guifang Han, Yi Wang, Jian Ding, Ling-huaMeng*, and Qingmin Wang* 6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.J. Med. Chem., 2017, 60 (7), 2764–2779

  11. Wenbo Liu, Jiangping Nie, Xiaoli Tan, Huiqiang Liu, Nannan Yu, Guifang Han, Yutian Zhu, Frederick A. Villamena, Yuguang Song, Jay L. Zweier,* and Yangping Liu*. Synthesis and Characterization of PEGylated Trityl Radicals: Effect ofPEGylation on Physicochemical Properties. J. Org. Chem. 2017, 82, 588-596.

  12. Guifang Han, Qiang Wang, Linwei Chen, Yuxiu Liu, and Qingmin Wang* Copper-Catalyzed Trifluoromethylation of Acrylamide Coupled with Dearomatization of Indole: Access to CF3‑Containing Spiro[indole-3,3'-pyrrolidine].Adv. Synth. Catal.2016,358(4), 561-566. Highlighted in Cheminform, 2016, 47.

  13. Guifang Han, Yuxiu Liu, and Qingmin Wang*. Copper-Catalyzed IntramolecularTrifluoromethylation of N‑Benzylacrylamides Coupled with Dearomatization: Access to CF3‑Containing 2‑Azaspiro[4.5]decanes.Org. Lett. 2014, 16, 3188−3191. Highlighted in ChemInform 2015, 45

  14. Guifang Han, Qiang Wang, Yuxiu Liu, and Qingmin Wang* Copper-Mediated α-Trifluoromethylation of N-phenylcinnamamides Coupled with Dearomatization: Access to Trifluoromethylated 1-Azaspiro[4.5]decanes. Org. Lett. 2014, 16, 5914-5917. Highlighted in ChemInform2014,16

  15. Guifang Han, Yuxiu Liu, and Qingmin Wang*. Total Synthesis of Phenanthroindolizidine Alkaloids through an Amidyl Radical Cascade/Rearrangement Reaction.Org. Lett. 2013, 15, 5334−5337. (IF: 6.324)

  16. Qiang Wang, Guifang Han, Yuxiu Liu, and Qingmin Wang*.Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2(1H)-ones. Adv. Synth. Catal. 2015, 357, 2464–2468. 

  17.  Meng Wu, Guifang Han, Chuisong Meng, Ziwen Wang, Yuxiu Liu, and Qingmin Wang*. Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of glycoconjugates of phenanthroindolizidines alkaloids. Mol. Divers.2014, 18, 25−37.

  18. Meng Wu, Guifang Han, Ziwen Wang, Yuxiu Liu, and Qingmin Wang*.Synthesis and Antiviral Activities of Antofine Analogues with Different C-6 Substituent Groups.J. Agric. Food Chem. 2013, 61, 1030−1035.

  19. Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Meng Wu, Guifang Han, Yaxin Lu*, Qingming Wang*, and Zheng Yin*. Optimization of on-line solid phase extraction and HPLC conditions using response surface methodology for determination of WM-5 in mouse plasma and its application to pharmacokinetic study. J. Chromatogr. B. 2013, 923−924.

  20. Ziwen Wang, Meng Wu, Yi Wang, Zheng Li, Lei Wang,Guifang Han, Fazhong Chen, Yuxiu Liu, Kailiang Wang, Ao Zhang*,LinghuaMeng*, and Qingmin Wang*. Synthesis and SAR Studies of Phenanthroindolizidine and Phenanthroquinolizidine Alkaloids as Potent Anti-tumor Agents. Eur. J. Med. Chem. 2012, 51, 250−258.

Grant

National Natural ScienceFoundation of China (21603163, 21772146)