Xianchao Cheng, MD.

Xian-Chao Cheng, Ph.D

Associate Professor

School of Pharmacy

Tianjin Medical  University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336658

Email: chengxianchao@

Education

Ph.D.  Shandong University, Jinan, China, 2008

Postdoctoral Fellow  Tianjin Medical University, Tianjin, China, 2014

Professional Experience

2008-2012    Lecturer, School of Pharmacy, Tianjin Medical University, Tianjin, China

2012-    Associate Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China

Publication

1. Xiao-Yan Feng, Ting-Ting Ding, Ya-Ya Liu, Wei-Ren Xu, Xian-Chao Cheng*. In-silico identification of peroxisome proliferator-activated receptor (PPAR)α/γ agonists from Ligand Expo Components database. Journal of Biomolecular Structure and Dynamics, 2021, 39 (5), 1853-1864.

2. Wen-Qing Jia, Ya-Ya Liu, Xiao-Yan Feng, Wei-Ren Xu, Xian-Chao Cheng*. Discovery of novel and highly selective PI3Kδ inhibitors based on the p110δ crystal structure. Journal of Biomolecular Structure and Dynamics, 2020, 38 (8): 2499-2508.

3. Wen-Qing Jia, Xiao-Yan Feng, Ya-Ya Liu, Zhen-Zhen Han, Zhi Jing, Wei-Ren Xu, Xian-Chao Cheng*. Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure. Letters in Drug Design & Discovery, 2020, 17 (6), 772-786.

4. Ya-Ya Liu, Ting-Ting Ding, Xiao-Yan Feng, Wei-Ren Xu, Xian-Chao Cheng*. Virtual identification of novel peroxisome proliferator-activated receptor (PPAR) α/δ dual antagonist by 3D-QSAR, molecule docking, and molecule dynamics simulation. Journal of Biomolecular Structure and Dynamics, 2020, 38 (14): 4143-4161.

5. Ya-Ya Liu, Xiao-Yan Feng, Wen-Qing Jia, Zhi Jing, Wei-Ren Xu, Xian-Chao Cheng*. Virtual identification of novel PPARα/γ dual agonists by 3D-QSAR, molecule docking and molecular dynamics studies. Journal of Biomolecular Structure and Dynamics, 2020, 38 (9): 2672-2685.

6. Xiao-Yan Feng, Wen-Qing Jia, Xin Liu, Zhi Jing, Ya-Ya Liu, Wei-Ren Xu, Xian-Chao Cheng. Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations. Computational Biology and Chemistry, 2019, 78: 178-189.

7. Ya-Ya Liu, Xiao-Yan Feng, Wen-Qing Jia, Zhi Jing, Wei-Ren Xu, Xian-Chao Cheng*. Identification of novel PI3Kδ inhibitors by docking, ADMET prediction and molecular dynamics simulations. Computational Biology and Chemistry, 2019, 78: 190-204.

8. Mei-Yan Wang, Xian-Chao Cheng (co-first author), Xiu-Bo Chen, Yu Li, Lan-Lan Zang, Yu-Qing Duan, Ming-Zhu Chen, Peng Yu, Hua Sun*, Run-Ling Wang*. Synthesis and biological evaluation of novel N-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of alpha-glucosidase and protein tyrosine phosphatase 1B. Chemical Biology & Drug Design, 2018, 92 (3): 1647-1656.

9. Wen-Qing Jia, Zhi Jing, Xin Liu, Xiao-Yan Feng, Ya-Ya Liu, Shu-Qing Wang, Wei-Ren Xu, Jian-Wen Liu* and Xian-Chao Cheng*. Virtual identification of novel PPARα/γ dual agonists by scaffold hopping of saroglitazar. Journal of Biomolecular Structure and Dynamics, 2018, 36 (13), 3496-3512.

10. Xin Liu, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Ying Ma*, Wei-Ren Xu, Jian-Wen Liu* and Xian-Chao Cheng*. Identification of novel PPARα/γ dual agonists by virtual screening, ADMET prediction and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 2018, 36 (11), 2988-3002.

11. Xin Liu, Yu-Ze Zhang, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Wei-Ren Xu and Xian-Chao Cheng*. Molecular Docking, 3D-QSAR and Structural Optimization of Indole Biphenylcarboxylic Acids as PPARγ Antagonists. Letters in Drug Design & Discovery, 2017, 14, 959-973.

12. Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng* and Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan. Journal of Biomolecular Structure and Dynamics, 2017, 35 (12): 2665-2680.

13. Jun Zhang, Xin Liu, Xian-Bin Xie, Xian-Chao Cheng*, Run-Ling Wang. Multitargeted bioactive ligands for PPARs discovered in the last decade. Chemical Biology & Drug Design, 2016, 88: 635-663.

14. Jun Zhang, Xin Liu, Shu-Qing Wang, Jing-Wei Fu, Wei-Ren Xu, Xian-Chao Cheng* and Run- Ling Wang. Identification of Novel PPARα/γ Dual Agonists by Virtual Screening of Specs Database. Combinatorial Chemistry & High Throughput Screening, 2016, 19 (8): 644-655.

15. Jun Zhang, Xue-Jiao Wang, Zhen-Ke Dong, Shu-Qing Wang, Wei-Ren Xu, Jing-Wei Fu, Xian-Chao Cheng*, Run-Ling Wang. CoMFA/CoMSIA and Molecular Docking Studies of Novel Matrix Metalloproteinase-2 Inhibitors Based on L-tyrosine Scaffold. Letters in Drug Design & Discovery, 2016, 13(5): 376-386.

16. Mei-Yan Wang, Yuan-Yuan Jin, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry, 2015, 103, 91-104.

17. Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone. Drug Design, Development and Therapy, 2014, 8, 2255–2262.

18. Lan-Lan Zang, Xue-Jiao Wang, Xiao-Bo Li, Shu-Qing Wang, Wei-Ren Xu, Xian-Bin Xie, Xian-Chao Cheng*, Huan Ma, Run-Ling Wang*. SAHA-based novel HDAC inhibitor design by core hopping method. Journal of Molecular Graphics and Modelling, 2014, 54, 10-18.

Grant

Ongoing:

Discovery of anti-diabetic lead compounds multi-targeting PPARs. Natural Science Foundation of Tianjin (18JCYBJC28800), 2018.04-2022.03.

Completed:

Design, Synthesis and Activity Studies of PPARs Multi-targeted Antidiabetic Agents. National Natural Science Foundation of China (21202120), 2013.01-2015.12.