Jingli Hou , Ph.D.

Jingli Hou, Ph.D

Associate professor

School of Pharmacy

Tianjin Medical University

22 Qixiangtai Road

Tianjin 30000780

Phone: +8613821429208

Email: jinglihou@tmu.edu.cn

Education

B.S.        Hebei University, Baoding, China, 2004

M.S.      Nankai University, Tianjin, China, 2008

Ph.D.   Nankai University, Tianjin, China, 2012

Postdoctoral Fellow   Nankai University, Tianjin, China, 2014

Professional Experience

2019/12 - till now   Associate professor, Department of Pharmacy, Tianjin Medicinal University

2014- 2019/12     Assistant professor, Department of Pharmacy, Tianjin Medicinal University

2013/09-2014/01   Postdoctoral fellow in Chemistry, Georgia State University, Atlanta, GA

2012/07-2014/07   Postdoctoral fellow in Medicinal Chemisty, Nankai University, Tianjin, China

2011/07-2011/07   Internship in glaxosmithkline (gsk) R &D, King of Prussia, PA

Honors

The University Prize (Third class) for young teachers’ basic skills competition. Tianjin Medical University

Publication

1. Dashuai Zhu^#,Jingli Hou^# (co-first author), Meng Qian^#, Dawei Jin, Tian Hao, Yanjun Pan, He Wang, Shuting Wu, Shuo Liu, Fei Wang, Lanping Wu, Yumin Zhong, Zhilu Yang, Yongzhe Che, Jie Shen, Deling Kong, Meng Yin^*, Qiang Zhao^*. Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery. Nat. Commun. 2021, 12: 4501

2. Yongfang Liao, Zizhen Ye, Meng Qian, Xing Wang, Yuda Guo, Guifang Han, Yuguang Song, Jingli Hou^* and Yangping Liu^*. Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications. Org. Biomol.Chem. 2020, 18: 5473-5480

3. Yingchun Li, Weixiang Zhai, Yongfang Liao, Jiangping Nie, Guifang Han, Yuguang Song, Shaoyong Li, Jingli Hou*, Yangping Liu*. Synthesis of Central Chirality-Containing Triarylmethanols and Triarylmethyl Radicals with Extraordinarily Stable Configurations. J. Org. Chem. 2019, 84(18), 11774-11782

4. Jingli Hou^#, Yiwa Pan^#, Dashuai Zhu^#, Yueyuan Fan, Guowei Feng, Yongzhen Wei, He Wang, kang Qin, Tiechan Zhao, Qiang Yang, Yan Zhu, Yongzhe Che, Yangping Liu, Jiansong Cheng^*, Deling Kong, Peng George Wang, Jie Shen^*, Qiang Zhao^*. Targeted delivery of nitric oxide via a “bump-and-hole”-based enzyme/prodrug pair. Nat. Chem. Biol. 2019, 15(2), 151-160.

5. Jingli Hou, Haiyan He, Saipeng Huang, Meng Qian, Jie Wang, Xiaoli Tan, Guifang Han, Yuguang Song^*, Zhelong Xu^*, Yangping Liu^*. A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury. Chem. Commun.2019, 55(9), 1205-1208.

6. Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song^*,Yangping Liu^*, A Near-Infrared Ratiometric/Turn-on Fluorescent Probe for In VivoImaging of Hydrogen Peroxide in a Murine Model of Acute Inflammation,Anal. Chim. Acta.2018,1024:169-176.

7. Xiulan, Li^#,Jingli Hou^#, Chao Peng, Li Chen, Wenbo Liu, Yangping Liu^*. A 1,8-naphthalimide-based fluorescent probe for selective and sensitive detection of peroxynitrite and its applications in living cell imaging.RSC Adv. 2017, 7:34287-34292. (Co-first author)

8. Guifang Han^#, Li Xue^#, Lili Zhao, Tiaozhen Zhu, Jingli Hou, Yuguang Song*, Yangping Liu*. Access to CF₃-Containing Cyclopentaquinolinone Derivatives from Indolyl-ynones via Silver-Catalyzed One-pot Reaction. Adv. Synth. Catal. 2019, 361: 678-682

9. Jingli hou, Zhonghua Li, Qinghong Fang,Congran Feng, Hanwen Zhang, Weikang Guo, Huihui Wang, Guoxian Gu, Yinping Tian, Pi Liu, Ruihua Liu, Jianping Lin, Yi-Kang Shi, Zheng Yin, Jie Shen^*, Peng George Wang^*. Discovery and Extensive in vitro Evaluations ofNK-HDAC-1: a chiral Histone Deacetylase Inhibitor as a promising lead. J. Med.Chem.2012, 55(7): 3066-3075.

10. Jingli hou, Congran Feng, Zhonghua Li, Qinghong Fang,Huihui Wang, Guoxian Gu, Yikang Shi, Pi Liu, Feng Xu, Zheng Yin, Jie Shen^*, Peng Wang^*. Structure-based optimization of click-basedhistone deacetylase inhibitors. Eur. J. Med. Chem.2011, 46(8): 3190-200.

11. Jingli hou, Xifang Liu, Jie Shen^*, Guilong Zhao^*, Peng George Wang^*. The impact of click chemistry in medicinal chemistry. Expert Opin. Drug Dis.2012, 7: 489-501.

12. Guangxiang Ren^#, Jingli Hou^#, Qinghong Fang, Hong Sun, Xiaoyan Liu, Lianwen Zhang^*, Peng George Wang^*. Synthesis of flavonol 3-O-glycosides by UGT78D1. Glycoconj. J. 2012, 29, 425-432.(Co-first author)

13. Wang peng; Shen jie; Yin, Zheng; Jingli hou. Histone deacetylase inhibitors with branchedstructure synthesized through click chemistry.WO2011003365

14. Teng Da-yong, Hou Jing-li, Zhang Xin-ge^*, Li Chao-xing^*. Glucosamine-carrying tempetature- and PH-sensitive microgels: Preparation, characterization, and in vitro drug release studies. J. Colloid Interf. Sci. 2008, 322:333-341.

Grant

Ongoing:

National Natural Science Foundation of China (NO: 81973269), 2020/01-2023/12, Role: PI

Completed:

National Natural Science Foundation of China (NO: 81603064), 2017/01-2019/12, Role: PI;

Science & Technology projects of Tianjin (18JCYBJC95300), 2018/10-2021/9, Role: PI

National Natural Science Foundation of Tianjin Medical University, 2016/01-2018/04

China Postdoctoral Natural Science Foundation Award, First-class Award (2013)