Run-Ling Wang, Ph.D.
Run-Ling Wang, PhD
Professor
School of pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-83336690
Email: wangrunling@tmu.edu.cn
Education
MD Peking University Health Science Center, Beijing, China, 1982
Ph.D. Tianjin University, Tianjin, China, 2006
Professional Experience
1982.07-1984.09 Assistant, Department of Pharmacy, Tianjin Medical University, Tianjin, China
1984.10-1994.09 Instructor, Department of Pharmacy, Tianjin Medical University, Tianjin, China
1994.10-1999.09 Associate Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China
1999.10-2015.04 Associate dean, Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China
2015.5- Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China
Honors
2016, The Ninth Tianjin Teachers' College Teaching Award;
2009, Tianjin outstanding teachers;
2009, The second prize of Tianjin Municipal Teaching Achievement Award of Higher Education in The Reform and Practice of Practice Teaching in Pharmacy;
2008, The major award of Teaching Achievements of Tianjin Medical University;
2013, The Excellent Teaching Instructor Award for Tianjin University Students Extracurricular Academic Work Competition in the Twelfth Challenge Cup;
2003, Presided over the development of arginine ibuprofen and its syrup, won the third prize of Tianjin Science and Technology Progress;
1997, Presided over the ibuprofen syrup bioavailability study project, won the Tianjin Municipal Health Bureau third prize for progress of science and technology;
2003, The honorary of advanced individual in Tianjin 10th Five-Year Plan;
2001, Presided over the reform of chemistry experiment Ⅱ and won the Tianjin Municipal Education Commission laboratory construction individual award.
2006 Tianjin Medical University fifteen advanced individual in science and technology work;
2012 Excellent Instructor of Science and Technology Innovation in Tianjin Medical University;
2002 The Outstanding Contribution Award of Tianjin Medical University in the course of scientific research during the Ninth Five-Year Plan;
The outstanding teachers in Tianjin Medical University in 2002 and 1999.
1997 The outstanding young technician awarded by Tianjin Municipal Health Bureau;
1998-2000 The cross-century talent awarded by the Tianjin Medical University.
Books
Medicinal Chemistry, editor-in-chief, First edition, 2013.7, The Tsinghua University Press
Medicinal Chemistry, editor-in-chief, Third edition, 2012.5, The Medical Science and Technology Press
Experiment II of Pharmacy chemistry, editor-in-chief, 2008.7, People's Medical Publishing House
Medicinal Chemistry, Cenbian, Seventh edition, 2011.8, People's Medical Publishing House
Medicinal Chemistry, Cenbian, Second edition, 2011.2, China Medical Science and Technology Press
Clinical pharmaceutical chemistry, Editorial Board, 2007.8, People's Medical Publishing House
Modern Drug Design, Editorial Board, 2006, China Medical Science and Technology Press
Publication
1 Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan [J]. Journal of Biomolecular Structure and Dynamics, 2017, 35 (12): 2665–2680
2 Yue-Qin Zheng, Yu-Qing Duan, Kai-Li Ji, Run-Ling Wang*, Bing-He Wang*. Tuning the reaction rates of fluoride probes for detection in aqueous solution [J]. RSC Advances, 2016, 6, 25242–25245
3 Xiao-Bo Li, Lei Dong, Wei-Ren Xu, Soumitra S. Bhuyan, Chenglung Chen, Run-Ling Wang. Study of SHP-2 (PTPN11) allosterism on structural movement using solution perturbed molecular dynamics simulation [J]. Journal of Molecular Liquids, 2016, 223, 509-515
4 Liu-Qing Wen, Lan-Lan Zang, Kenneth Huang, Shan-Shan Li, Run-Ling Wang*, Peng George Wang*. Efficient enzymatic synthesis of L-rhamnulose and L-fuculose [J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 (3): 969-972
5 Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng *, Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator activated receptor-γ by core hopping of telmisartan [J]. Journal of Biomolecular Structure and Dynamics, 2016, 7, 1-16
6 Mei-Yan Wang, Yuan-Yuan Jin, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors [J]. European Journal of Medicinal Chemistry, 2015, 103, 91-104
7 Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng, Run-Ling Wang*. Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone [J]. Drug Design, Development and Therapy, 2014, 8, 2255-2262
8 Ying Ma, Yuan-Yuan Jin, Ye-Liu Wang, Run-Ling Wang*, Xin-Hua Lu, De-Xin Kong, Wei-Ren Xu. The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D-QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, and Biological Evaluation [J]. Chemical Biology & Drug Design, 2014, 83, 697-709
9 Lan-Lan Zang, Xue-Jiao Wang, Xiao-Bo Li, Shu-Qing Wang, Wei-Ren Xu, Xian-Bin Xie, Xian-Chao Cheng, Huan Ma, Run-Ling Wang*. SAHA-based novel HDAC inhibitor design by core hopping method [J]. Journal of Molecular Graphics and Modelling, 2014, 54, 10-18
10 Jing-Wei Wu, Huan Zhang, Yu-Qing Duan, Wei-Li Dong, Xian-Chao Cheng, Shu-Qing Wang, Run-Ling Wang*. Design Novel Inhibitors for Treating Cancer by Targeting Cdc25B Catalytic Domain with De Novo Design [J]. Combinatorial chemistry & high throughput screening, 2014, 17(10): 837-847
11 Yu-Qing Duan, Ying Ma, Xue-Jiao Wang, Yuan-Yuan Jin, Run-Ling Wang*, Wei-Li Dong, Wei-Ren Xu, De-Xin Kong, Shu-Qing Wang*. Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach [J]. Protein & Peptide Letters, 2014, 21(6): 556-563
12 Yuan-Yuan Jin, Ying Ma, Quan-Xiong Gao, Run-Ling Wang*, Shu-Qing Wang, Wei-Ren Xu. Design of specific inhibitors of the protein tyrosine phosphatase SHP-2 by virtual screening and core hopping method [J]. Molecular Simulation, 2014, 40 (12): 904–911
13 Wei-Bing Zhang, Wen-Bo Liu, Jing-Wei Wu, Wei-Li Dong, Shu-Qing Wang*, Run-Ling Wang*. The derivatives of oseltamivir design passing through the important cleft of neuraminidase against influenza virus by de novo design [J]. Molecular Simulation, 2014, 40(15): 1209–1217
14 Ying Ma, Su-Xia Sun, Xian-Chao Cheng, Shu-Qing Wang, Wei-Li Dong, Run-Ling Wang*, Wei-Ren Xu. Design and Synthesis of Imidazolidine-2,4-Dione Derivatives as Selective Inhibitors by Targeting Protein Tyrosine Phosphatase-1B Over T-Cell Protein Tyrosine Phosphatase [J]. Chemical Biology & Drug Design, 2013, 82(5): 595-602
15 Su-Xia Sun, Xiao-Bo Li, Wen-Bo Liu, Ying Ma, Run-Ling Wang*, Xian-Chao Cheng, Shu-Qing Wang, Wei Liu. Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2 [J]. International journal of molecular sciences, 2013, 14, 12661-12674
16 Lei Liu, Ying Ma, Run-Ling Wang*, Wei-Ren Xu, Shu-Qing Wang*, Kuo-Chen Chou. Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics [J]. Drug Design Development and Therapy, 2013, 7, 279-288
17 Wen-Ming Li, Xiao-Bo Li, Su-Xia Sun, Jing Liang, Run-Ling Wang*, Shu-Qing Wang. Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics Simulation [J]. Molecular Simulation, 2013, 39(3):228-233
18 Xian-Chao Cheng, Run-Ling Wang*, Zhen-Ke Dong, Jing Li, Yao-Yuan Li, Rong-Rong Li. Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold [J]. Bioorganic & Medicinal Chemistry, 2012, 20, 5738–5744
19 Ying Ma, Shu-Qing Wang*, Wei-Ren Xu, Run-Ling Wang*, Kuo-Chen Chou. Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach [J]. PLoS ONE, 2012, 7(6): e38546
Grant
Ongoing:
NSFT(16JCZDJC32500),2016/04-2019/03, PI, The research on the selective SHP2 D61G、E76K inhibitors;
The International (Regional) Cooperation and Exchange Project of the National Natural Science Foundation of China(81611130090), 2016/01-2018/12, PI, Rational design, synthesis and activity screening of Shp2 inhibitors for treatment of leukemia.
Completed:
NSFC(81273361), 2013/01-2016/12, PI, The research on the selective protein tyrosine phosphatase SHP2 inhibitors;
NSFC(20972112), 2010/01-2012/12, PI, The design, synthesis, and biological study of antidiabetic drugs targeting PTP-1B, PPAR-α and PPAR-γ;
Key project of Tianjin Natural Science Foundation (09JCZDJC21600), 2009/04-2012/03, PI, The research based on the structure of PTP1B enzyme to discover lead antidiabetic drugs;
the Specialized Research Fund for the Doctoral Program of Higher Education of China(20091202110010), 2010/01-2012/12,PI, The design, synthesis, and biological study of antidiabetic drugs targeting PTP-1B, PPAR-α and PPAR-γ.
